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World Journal of Surgery
Published in: World Journal of Surgery 1/2013

01-01-2013

Risk Factors of Hypoparathyroidism Following Total Thyroidectomy for Thyroid Cancer

Authors: Se Hyun Paek, Young Mi Lee, Sun Young Min, Seok Won Kim, Ki Wook Chung, Yeo Kyu Youn

Published in: World Journal of Surgery | Issue 1/2013

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Abstract

Background

The risk factors responsible for hypoparathyroidism after total thyroidectomy have not been completely defined. The present study evaluated one surgeon’s personal experience of postoperative hypoparathyroidism after total thyroidectomy for thyroid cancer and predisposing risk factors of postoperative hypoparathyroidism.

Methods

We performed a retrospective analysis of 531 consecutive total thyroidectomy cases for thyroid cancer operated by single surgeon at the Center for Thyroid Cancer, National Cancer Center, Korea, from March 2003 to August 2006.

Results

Postoperative hypoparathyroidism occurred in 135 patients (25.4 %), 19 of whom (3.6 % of total patients) experienced permanent hypoparathyroidism. Parathyroid autotransplantation, bilateral central lymph node dissection, gross extrathyroidal extension, and the presence of parathyroid gland in the pathologic specimen were associated with postoperative hypoparathyroidism in multivariate analysis (p < 0.05, respectively). The presence of parathyroid gland in the pathologic specimen and the early period of surgeon’s practice were statistically significant risk factors for permanent hypoparathyroidism in multivariate analysis (p < 0.05, respectively).

Conclusions

Careful surgical technique for in situ preservation of parathyroid gland and autotransplantation of inadvertently removed parathyroid gland are important, especially in case of gross extrathyroidal extension. Adequate surgical experience is also an important factor. And routine bilateral central lymph node dissection should be done thoughtfully for its effect on postoperative hypoparathyroidism.
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Metadata
Title
Risk Factors of Hypoparathyroidism Following Total Thyroidectomy for Thyroid Cancer
Authors
Se Hyun Paek
Young Mi Lee
Sun Young Min
Seok Won Kim
Ki Wook Chung
Yeo Kyu Youn
Publication date
01-01-2013
Publisher
Springer-Verlag
Published in
World Journal of Surgery / Issue 1/2013
Print ISSN: 0364-2313
Electronic ISSN: 1432-2323
DOI
https://doi.org/10.1007/s00268-012-1809-4

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