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Published in:

01-04-2006 | Original

Risk factors for reperfusion injury after lung transplantation

Authors: Silvia R. Cottini, Nicolas Lerch, Marc de Perrot, Miriam M. Treggiari, Anastase Spiliopoulos, Laurent Nicod, Bara Ricou

Published in: Intensive Care Medicine | Issue 4/2006

Abstract

Objective

To assess the influence of recipient's and donor's factors as well as surgical events on the occurrence of reperfusion injury after lung transplantation.

Design and setting

Retrospective study in the surgical intensive care unit (ICU) of a university hospital.

Methods

We collected data on 60 lung transplantation donor/recipient pairs from June 1993 to May 2001, and compared the demographic, peri- and postoperative variables of patients who experienced reperfusion injury (35%) and those who did not.

Results

The occurrence of high systolic pulmonary pressure immediately after transplantation and/or its persistence during the first 48 h after surgery was associated with reperfusion injury, independently of preoperative values. Reperfusion injury was associated with difficult hemostasis during transplantation (p = 0.03). Patients with reperfusion injury were more likely to require the administration of catecholamine during the first 48 h after surgery (p = 0.014). The extubation was delayed (p = 0.03) and the relative odds of ICU mortality were significantly greater (OR 4.8, 95% CI: 1.06, 21.8) in patients with reperfusion injury. Our analysis confirmed that preexisting pulmonary hypertension increased the incidence of reperfusion injury (p < 0.01).

Conclusions

Difficulties in perioperative hemostasis were associated with reperfusion injury. Occurrence of reperfusion injury was associated with postoperative systolic pulmonary hypertension, longer mechanical ventilation and higher mortality. Whether early recognition and treatment of pulmonary hypertension during transplantation can prevent the occurrence of reperfusion injury needs to be investigated.

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Title: Risk factors for reperfusion injury after lung transplantation
Authors: Silvia R. Cottini
Nicolas Lerch
Marc de Perrot
Miriam M. Treggiari
Anastase Spiliopoulos
Laurent Nicod
Bara Ricou
Publication date: 01-04-2006
Publisher: Springer-Verlag
Published in: Intensive Care Medicine / Issue 4/2006
Print ISSN: 0342-4642
Electronic ISSN: 1432-1238
DOI: https://doi.org/10.1007/s00134-006-0096-7

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Risk factors for reperfusion injury after lung transplantation

Abstract

Objective

Design and setting

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objective

Design and setting

Methods

Results

Conclusions

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