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International Journal of Mental Health Systems
Published in: International Journal of Mental Health Systems 1/2018

Open Access 01-12-2018 | Research

Risk factors for relapse in patients with first-episode schizophrenia: Analysis of the Health Insurance Review and Assessment Service data from 2011 to 2015

Authors: Sang-Uk Lee, Minah Soh, Vin Ryu, Chul-Eung Kim, Subin Park, Sungwon Roh, In-Hwan Oh, Hye-Young Lee, SungKu Choi

Published in: International Journal of Mental Health Systems | Issue 1/2018

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Abstract

Background

Schizophrenia is a recurrent, debilitating disease that is rarely curable. Rapid intervention after the first episode of schizophrenia has been shown to positively affect the prognosis. Unfortunately, basic data is scarce on first-episode schizophrenia in Korean patients making it difficult to create a comprehensive list of risk factors for relapse. This study aims to investigate the demographic characteristics and institutional factors of patients with first-episode schizophrenia in order to identify risk factors for relapse.

Methods

Data from the Health Insurance Review & Assessment Service (HIRA) was used for this study to represent the Korean patient population. To identify factors affecting relapse, we explored gender, age, geographic location, medical benefits, type of medical institution, type of medication used, medication adherence, and the severity of symptoms. Data analysis was performed using the Cox proportional hazard model.

Results

The number of patients diagnosed with first-episode schizophrenia in Korea over a 2-year period was 4567 of which 1265 (27.7%) patients experienced a relapse during the observational period. Factors affecting relapse included age, type of medical institution, type of medication used, medication adherence, and type of treatment (inpatient or outpatient) after the initial diagnosis, which varied depending upon the severity of symptoms.

Conclusions

It was found that environmental and institutional factors as well as the type of medical treatment were crucial in determining whether patients with first-episode schizophrenia subsequently relapsed. The results of this study can be utilized as source material for directing therapeutic interventions and improving mental health policies in the future.
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Metadata
Title
Risk factors for relapse in patients with first-episode schizophrenia: Analysis of the Health Insurance Review and Assessment Service data from 2011 to 2015
Authors
Sang-Uk Lee
Minah Soh
Vin Ryu
Chul-Eung Kim
Subin Park
Sungwon Roh
In-Hwan Oh
Hye-Young Lee
SungKu Choi
Publication date
01-12-2018
Publisher
BioMed Central
Published in
International Journal of Mental Health Systems / Issue 1/2018
Electronic ISSN: 1752-4458
DOI
https://doi.org/10.1186/s13033-018-0187-1

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