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International Journal of Colorectal Disease
Published in: International Journal of Colorectal Disease 4/2013

01-04-2013 | Original Article

Risk factors for anastomotic leakage following anterior resection for colorectal cancer: the effect of epidural analgesia on occurrence

Authors: Renchun Lai, Yali Lu, Qiuli Li, Jin Guo, Gong Chen, Weian Zeng

Published in: International Journal of Colorectal Disease | Issue 4/2013

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Abstract

Purpose

The effect of thoracic epidural analgesia (TEA) on anastomotic leakage (AL) after anterior resection for colorectal cancer is controversial. The aim of this study was to evaluate the risk factors including TEA for the occurrence of AL after anterior resection for colorectal cancer.

Methods

This retrospective study included 1,312 patients with colorectal cancer who underwent anterior resection between 2000 and 2011 at the Cancer Center, Sun Yat-sen University. Univariate and multivariate logistics analyses were performed to determine the risk factors, including TEA, for AL. Additionally, we evaluated the effect of TEA on outcome parameters.

Results

AL occurred in 118 (9 %) of the 1,312 patients. In univariate analysis, the American Society of Anesthesiologists (ASA) score, history of hypertension, episodes of hypotension, anastomosis technique, tumor localization, anesthesia duration, and perioperative blood transfusion were significant risk factors for AL. Multivariate analysis showed that ASA (P = 0.001), perioperative blood transfusion (P < 0.001), anastomosis technique (P = 0.019), anesthesia duration (P = 0.033), and tumor localization (P = 0.009) were independent factors affecting AL. TEA had no effect on the occurrence of AL (P = 0.451) in multivariate analysis. However, the length of hospital stay was shortened by the use of TEA (P < 0.001).

Conclusions

The results of this retrospective study suggest that TEA has no effect on the occurrence of AL. However, TEA may be recommended to shorten the length of hospital stay.
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Metadata
Title
Risk factors for anastomotic leakage following anterior resection for colorectal cancer: the effect of epidural analgesia on occurrence
Authors
Renchun Lai
Yali Lu
Qiuli Li
Jin Guo
Gong Chen
Weian Zeng
Publication date
01-04-2013
Publisher
Springer-Verlag
Published in
International Journal of Colorectal Disease / Issue 4/2013
Print ISSN: 0179-1958
Electronic ISSN: 1432-1262
DOI
https://doi.org/10.1007/s00384-012-1585-5

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