Skip to main content
Top
Published in: Indian Journal of Surgical Oncology 2/2018

01-06-2018 | Original Article

Right and Transverse Colonic Multi-Visceral Resections for Locally Advanced Cancers—a Single-Center Experience

Authors: Joseph Sebastian, Mohamed Boshnaq, Mohanraj Harilingam, Chukwuemeka Anele, Mansoor Akhtar, Deya Marzouk

Published in: Indian Journal of Surgical Oncology | Issue 2/2018

Login to get access

Abstract

Locally advanced colorectal tumors constitute to about 5–22% of all colorectal cancers at the time of presentation. Multi-visceral resection is usually required for such cases in order to achieve curative resection (R0). We aim to present our experience of right and transverse colonic en bloc resections and their outcomes. Retrospective review of a prospective database between February 2008 and December 2014. Case notes, operative findings, histopathology results, and follow-up records were analyzed. A total of 23 patients underwent en bloc multi-visceral resections for locally advanced right-sided or transverse colonic cancers. There were 11 males and 12 females. The mean age was 75 years. Fifteen patients were operated electively and eight were done as emergency. Median follow-up was 36 months. Eleven out of 23 (47%) had more than one organ resected. 78.3% had R0 resections, 17.4% were R1, and 4.3% were indeterminate. The average lymph node yield was 22 [range 5–45]. Senior trainees under supervision did 65% of procedures. Twelve-month disease-free survival was 90% and the 5-year survival was 65%. Right-sided and transverse colonic tumors have a propensity to become locally advanced making curative resections challenging. This is especially relevant when these patients present as an emergency or if the surgeon is less experienced and may opt for a palliative procedure, thus leading to suboptimal outcomes. Multi-visceral resections for locally advanced tumors can be feasible in the district general hospital setting with acceptable outcomes. Multi-disciplinary meeting (MDM) process, adequate training, and experience are vital.
Literature
1.
go back to reference Gebhardt C, Mayer W, Rukriegel S, Merier U (1999) Multivisceral resection of advanced colorectal carcinoma. Langenbeck's Arch Surg 384:194–199. https://doi.org/10.1007/s004230050191]. Gebhardt C, Mayer W, Rukriegel S, Merier U (1999) Multivisceral resection of advanced colorectal carcinoma. Langenbeck's Arch Surg 384:194–199. https://​doi.​org/​10.​1007/​s004230050191].
2.
go back to reference Nelson H, Petrelli N, Carlin A et al (2001) Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst 93:583CrossRefPubMed Nelson H, Petrelli N, Carlin A et al (2001) Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst 93:583CrossRefPubMed
3.
go back to reference McGory ML, Shekelle PG, Ko CY (2006) Development of quality indicators for patients undergoing colorectal cancer surgery. J Natl Cancer Inst 98:1623CrossRefPubMed McGory ML, Shekelle PG, Ko CY (2006) Development of quality indicators for patients undergoing colorectal cancer surgery. J Natl Cancer Inst 98:1623CrossRefPubMed
4.
go back to reference Otchy D, Hyman NH, Simmang C, Anthony T, Buie WD, Cataldo P, Church J, Cohen J, Dentsman F, Ellis CN, Kilkenny JW 3rd, Ko C, Moore R, Orsay C, Place R, Rafferty J, Rakinic J, Savoca P, Tjandra J, Whiteford M (2004) Standards Practice Task Force; American Society of Colon and Rectal Surgeons. Practice parameters for colon cancer. Dis Colon rectum 47(8):1269–1284CrossRefPubMed Otchy D, Hyman NH, Simmang C, Anthony T, Buie WD, Cataldo P, Church J, Cohen J, Dentsman F, Ellis CN, Kilkenny JW 3rd, Ko C, Moore R, Orsay C, Place R, Rafferty J, Rakinic J, Savoca P, Tjandra J, Whiteford M (2004) Standards Practice Task Force; American Society of Colon and Rectal Surgeons. Practice parameters for colon cancer. Dis Colon rectum 47(8):1269–1284CrossRefPubMed
6.
go back to reference Govindarajan A, Coburn NG, Kiss A et al (2006) Population-based assessment of the surgical management of locally advanced colorectal cancer. J Natl Cancer Inst 98:1474CrossRefPubMed Govindarajan A, Coburn NG, Kiss A et al (2006) Population-based assessment of the surgical management of locally advanced colorectal cancer. J Natl Cancer Inst 98:1474CrossRefPubMed
7.
go back to reference Hermanek P, Gall FP, Altendorf A (1980) Prognostic groups in colo-rectal carcinoma. J Cancer Res Clin Oncol 98:185–193CrossRefPubMed Hermanek P, Gall FP, Altendorf A (1980) Prognostic groups in colo-rectal carcinoma. J Cancer Res Clin Oncol 98:185–193CrossRefPubMed
8.
go back to reference Hermanek P, Wittekind C (1994) Residual tumour (R) classification and prognosis. Semin Surg Oncol 10:12–20CrossRefPubMed Hermanek P, Wittekind C (1994) Residual tumour (R) classification and prognosis. Semin Surg Oncol 10:12–20CrossRefPubMed
9.
go back to reference Nelson H, Petrelli N, Carlin A, Couture J, Fleshman J, Guillem J, Miedema B, Ota D, Sargent D (2001) National Cancer Institute Expert Panel. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst 93(8):583–596CrossRefPubMed Nelson H, Petrelli N, Carlin A, Couture J, Fleshman J, Guillem J, Miedema B, Ota D, Sargent D (2001) National Cancer Institute Expert Panel. Guidelines 2000 for colon and rectal cancer surgery. J Natl Cancer Inst 93(8):583–596CrossRefPubMed
10.
go back to reference Hunter JA, Ryan JA Jr, Schultz P (1987) En bloc resection of colon cancer adherent to other organs. Am J Surg 154:67CrossRefPubMed Hunter JA, Ryan JA Jr, Schultz P (1987) En bloc resection of colon cancer adherent to other organs. Am J Surg 154:67CrossRefPubMed
11.
go back to reference Lehnert T, Methner M, Pollok A, Schaible A, Hinz U, Herfarth C (2002) Multivisceral resection for locally advanced primary colon and rectal cancer: an analysis of prognostic factors in 201 patients. Ann Surg 235(2):217–225CrossRefPubMedPubMedCentral Lehnert T, Methner M, Pollok A, Schaible A, Hinz U, Herfarth C (2002) Multivisceral resection for locally advanced primary colon and rectal cancer: an analysis of prognostic factors in 201 patients. Ann Surg 235(2):217–225CrossRefPubMedPubMedCentral
12.
go back to reference Kapoor S, Das B, Pal S, Sahni P, Chattopadhyay TK (2006) En-bloc resection of right-sided colonic adenocarcinoma with adjacent organ invasion. Int J Color Dis 21(3):265–268CrossRef Kapoor S, Das B, Pal S, Sahni P, Chattopadhyay TK (2006) En-bloc resection of right-sided colonic adenocarcinoma with adjacent organ invasion. Int J Color Dis 21(3):265–268CrossRef
13.
go back to reference Kaneda Y, Noda H, Endo Y, Kakizawa N, Ichida K, Watanabe F, Kato T, Miyakura Y, Suzuki K, Rikiyama T (2017) En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer. World J Gastrointest Oncol 9(9):372–378CrossRefPubMedPubMedCentral Kaneda Y, Noda H, Endo Y, Kakizawa N, Ichida K, Watanabe F, Kato T, Miyakura Y, Suzuki K, Rikiyama T (2017) En bloc pancreaticoduodenectomy and right hemicolectomy for locally advanced right-sided colon cancer. World J Gastrointest Oncol 9(9):372–378CrossRefPubMedPubMedCentral
14.
go back to reference Ağalar C, Canda AE, Unek T, Sokmen S (2017) En bloc pancreaticoduodenectomy for locally advanced right colon cancers. Int J Surg Oncol 2017:5179686PubMedPubMedCentral Ağalar C, Canda AE, Unek T, Sokmen S (2017) En bloc pancreaticoduodenectomy for locally advanced right colon cancers. Int J Surg Oncol 2017:5179686PubMedPubMedCentral
15.
go back to reference Newland RC, Dent OF, Chapuis PH, Bokey EL (1993) Clinicopathologically diagnosed residual tumor after resection for colorectal cancer. A 20-year prospective study. Cancer 72(5):1536–1542CrossRefPubMed Newland RC, Dent OF, Chapuis PH, Bokey EL (1993) Clinicopathologically diagnosed residual tumor after resection for colorectal cancer. A 20-year prospective study. Cancer 72(5):1536–1542CrossRefPubMed
16.
go back to reference Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17(6):1471–1474CrossRefPubMed Edge SB, Compton CC (2010) The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM. Ann Surg Oncol 17(6):1471–1474CrossRefPubMed
17.
go back to reference Bartoş A, Bartoş D, Dunca F, Mocanu L, Zaharie F, Iancu M, Mironiuc A, Iancu C (2012) Multi-organ resections for colorectal cancer: analysis of potential factors with role in the occurrence of postoperative complications and deaths. Chirurgia (Bucur) 107(4):476–482 Bartoş A, Bartoş D, Dunca F, Mocanu L, Zaharie F, Iancu M, Mironiuc A, Iancu C (2012) Multi-organ resections for colorectal cancer: analysis of potential factors with role in the occurrence of postoperative complications and deaths. Chirurgia (Bucur) 107(4):476–482
18.
go back to reference Larkin JO, O'Connell PR (2012) Multivisceral resection for T4 or recurrent colorectal cancer. Dig Dis 30(2):96–101CrossRefPubMed Larkin JO, O'Connell PR (2012) Multivisceral resection for T4 or recurrent colorectal cancer. Dig Dis 30(2):96–101CrossRefPubMed
19.
go back to reference Gebhardt C, Meyer W, Ruckriegel S, Meier U (1999) Multivisceral re- section of advanced colorectal carcinoma. Langenbeck's Arch Surg 384:194–199CrossRef Gebhardt C, Meyer W, Ruckriegel S, Meier U (1999) Multivisceral re- section of advanced colorectal carcinoma. Langenbeck's Arch Surg 384:194–199CrossRef
20.
go back to reference Nakafusa Y, Tanaka T, Tanaka M, Kitajima Y, Sato S, Miyazaki K (2004) Comparison of multivisceral resection and standard operation for locally advanced colorectal cancer: analysis of prognostic factors for short-term and long-term outcome. Dis Colon Rectum 47:2055–2063CrossRefPubMed Nakafusa Y, Tanaka T, Tanaka M, Kitajima Y, Sato S, Miyazaki K (2004) Comparison of multivisceral resection and standard operation for locally advanced colorectal cancer: analysis of prognostic factors for short-term and long-term outcome. Dis Colon Rectum 47:2055–2063CrossRefPubMed
21.
go back to reference Poeze M, Houbiers JG, van de Velde CJ et al (1995) Radical resection of locally advanced colorectal cancer. Br J Surg 82:1386CrossRefPubMed Poeze M, Houbiers JG, van de Velde CJ et al (1995) Radical resection of locally advanced colorectal cancer. Br J Surg 82:1386CrossRefPubMed
22.
go back to reference Lopez MJ, Monafo WW (1993) Role of extended resection in the initial treatment of locally advanced colorectal carcinoma. Surgery 113:365PubMed Lopez MJ, Monafo WW (1993) Role of extended resection in the initial treatment of locally advanced colorectal carcinoma. Surgery 113:365PubMed
Metadata
Title
Right and Transverse Colonic Multi-Visceral Resections for Locally Advanced Cancers—a Single-Center Experience
Authors
Joseph Sebastian
Mohamed Boshnaq
Mohanraj Harilingam
Chukwuemeka Anele
Mansoor Akhtar
Deya Marzouk
Publication date
01-06-2018
Publisher
Springer India
Published in
Indian Journal of Surgical Oncology / Issue 2/2018
Print ISSN: 0975-7651
Electronic ISSN: 0976-6952
DOI
https://doi.org/10.1007/s13193-018-0762-6

Other articles of this Issue 2/2018

Indian Journal of Surgical Oncology 2/2018 Go to the issue