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Clinical & Experimental Metastasis
Published in: Clinical & Experimental Metastasis 8/2007

01-11-2007 | Reseach Paper

Rho GTPases: functions and association with cancer

Authors: Saskia I. J. Ellenbroek, John G. Collard

Published in: Clinical & Experimental Metastasis | Issue 8/2007

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Abstract

Rho GTPases are small proteins that act as binary molecular switches in a wide range of signalling pathways upon stimulation of cell surface receptors. Three different classes of regulatory proteins control their activity. In the activated state small GTPases are able to bind a variety of effector proteins and initiate downstream signalling. Rho GTPases regulate important cellular processes ranging from cytoskeletal remodelling and gene expression to cell proliferation and membrane trafficking. Therefore it is not surprising that deregulated Rho signalling can contribute to disturbed cellular phenotypes in a wide range of diseases. The main focus of this review will be the diversity of functions of Rho GTPases and the effects of aberrant Rho GTPase signalling in various aspects of cancer.
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Metadata
Title
Rho GTPases: functions and association with cancer
Authors
Saskia I. J. Ellenbroek
John G. Collard
Publication date
01-11-2007
Publisher
Springer Netherlands
Published in
Clinical & Experimental Metastasis / Issue 8/2007
Print ISSN: 0262-0898
Electronic ISSN: 1573-7276
DOI
https://doi.org/10.1007/s10585-007-9119-1

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