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European Archives of Oto-Rhino-Laryngology

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15-07-2023 | Rhinosinusitis | Rhinology

The implications of concomitant mucosal inflammation on clinical manifestations and outcomes of sinonasal inverted papilloma

Authors: Noa Rozendorn, Arkadi Yakirevitch, Eran Glikson, Roee Landsberg, Amit Ritter, Francesco Mozzanica, Shay Schneider, Ethan Soudry

Published in: European Archives of Oto-Rhino-Laryngology | Issue 11/2023

Abstract

Purpose

This study examines the impact of concomitant mucosal inflammation on clinical manifestations and long-term outcomes of Inverted Papilloma (IP).

Methods

This retrospective cohort study was conducted in five tertiary medical centers. The included patients underwent an attachment-oriented surgical resection for IP with a minimum follow-up of 3 years.

Results

Of 185 patients with IP, 65 patients (35.1%) had synchronous mucosal inflammation with polypoid changes. The mean age was 56.7 years, and 69% were males. Most tumors originated from the maxillary sinus. Age, gender, Krouse stage, and tumor attachment site did not differ between the mucosal inflammation and IP-only groups. IP recurrence rate was twofold in the patients with mucosal inflammation (15.4% vs. 7.5%, p = 0.092). However, the difference was not significant, with a similar median time to recurrence between the two groups [15.5 (3–36) months vs. 16(6–96) months, p = 0.712]. In revision cases, IP recurred only in patients with mucosal inflammation (19% vs. 0%, p = 0.07). This group had a significantly worse 5-years recurrence-free survival than revision cases without mucosal inflammation (80.6% vs. 100%, p = 0.04).

Conclusions

IP in the setting of mucosal inflammation might be associated with a higher recurrence rate, predominantly after revision surgery. Otolaryngologists should consider this during these patients’ diagnosis, surgical planning, and follow-up.

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Title: The implications of concomitant mucosal inflammation on clinical manifestations and outcomes of sinonasal inverted papilloma
Authors: Noa Rozendorn
Arkadi Yakirevitch
Eran Glikson
Roee Landsberg
Amit Ritter
Francesco Mozzanica
Shay Schneider
Ethan Soudry
Publication date: 15-07-2023
Publisher: Springer Berlin Heidelberg
Keyword: Rhinosinusitis
Published in: European Archives of Oto-Rhino-Laryngology / Issue 11/2023
Print ISSN: 0937-4477
Electronic ISSN: 1434-4726
DOI: https://doi.org/10.1007/s00405-023-08088-5

Keynote webinar | Spotlight on medication adherence

Springer Medicine

The implications of concomitant mucosal inflammation on clinical manifestations and outcomes of sinonasal inverted papilloma

Abstract

Purpose

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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