Top

Journal of Cardiovascular Magnetic Resonance

Published in:

Open Access 01-12-2012 | Moderated poster presentation

RGD targeting of human ferritin iron-oxide nanoparticles enhances in vivo molecular MRI of experimental aortic aneurysms

Authors: Toshiro Kitagawa, Hisanori Kosuge, Masaki Uchida, Yasunori Iida, Ronald L Dalman, Trevor Douglas, Michael V McConnell

Published in: Journal of Cardiovascular Magnetic Resonance | Special Issue 1/2012

Excerpt

Both inflammation and angiogenesis contribute to the progression of abdominal aortic aneurysm (AAA) disease. RGD is a peptide binder of the αvβ3 integrin, which is expressed highly on activated macrophages and angiogenic endothelial cells. Human ferritin (HFn) is a nanoscale protein cage with 12nm diameter and 8nm interior cavity, which we have utilized as a platform for molecular/cellular imaging. We can genetically introduce RGD peptide to HFn. The purpose of this study is to evaluate RGD-conjugated HFn iron oxide nanoparticles for enhanced in vivo MRI of murine AAAs. …

Title: RGD targeting of human ferritin iron-oxide nanoparticles enhances in vivo molecular MRI of experimental aortic aneurysms
Authors: Toshiro Kitagawa
Hisanori Kosuge
Masaki Uchida
Yasunori Iida
Ronald L Dalman
Trevor Douglas
Michael V McConnell
Publication date: 01-12-2012
Publisher: BioMed Central
Published in: Journal of Cardiovascular Magnetic Resonance / Issue Special Issue 1/2012
Electronic ISSN: 1532-429X
DOI: https://doi.org/10.1186/1532-429X-14-S1-M9

At a glance: The STEP trials

Springer Medicine

RGD targeting of human ferritin iron-oxide nanoparticles enhances in vivo molecular MRI of experimental aortic aneurysms

Excerpt

At a glance: The STEP trials

Springer Medicine

Excerpt

Please log in to get access to this content

Other articles of this Special Issue 1/2012

Growth of the inferior cavopulmonary pathway in patients with a lateral tunnel fontan connection: quantification from serial magnetic resonance images

Flow-sensitive four-dimensional (4D) magnetic resonance imaging reveals abnormal blood flow pattern in the aorta and pulmonary trunk of patients with transposition of the great arteries operated with atrial baffle switch

Phase sensitive inversion recovery with simultaneous dark fat rendering by virtual chemical inversion

The incidence of nephrogenic systemic fibrosis in subjects receiving gadoversetamide for cardiovascular magnetic resonance

Segmental analysis of cardiac metabolism by hyperpolarized [1-13C] pyruvate: an in-vivo 3D MRI study in pigs

Lower extremity amputation increases oscillatory flow in the infrarenal aorta: A new potential risk factor for abdominal aortic aneurysm development