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Published in:

01-06-2009

Review: The Role of Neural Crest Cells in the Endocrine System

Authors: Meghan Sara Adams, Marianne Bronner-Fraser

Published in: Endocrine Pathology | Issue 2/2009

Abstract

The neural crest is a pluripotent population of cells that arises at the junction of the neural tube and the dorsal ectoderm. These highly migratory cells form diverse derivatives including neurons and glia of the sensory, sympathetic, and enteric nervous systems, melanocytes, and the bones, cartilage, and connective tissues of the face. The neural crest has long been associated with the endocrine system, although not always correctly. According to current understanding, neural crest cells give rise to the chromaffin cells of the adrenal medulla, chief cells of the extra-adrenal paraganglia, and thyroid C cells. The endocrine tumors that correspond to these cell types are pheochromocytomas, extra-adrenal paragangliomas, and medullary thyroid carcinomas. Although controversies concerning embryological origin appear to have mostly been resolved, questions persist concerning the pathobiology of each tumor type and its basis in neural crest embryology. Here we present a brief history of the work on neural crest development, both in general and in application to the endocrine system. In particular, we present findings related to the plasticity and pluripotency of neural crest cells as well as a discussion of several different neural crest tumors in the endocrine system.

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Title: Review: The Role of Neural Crest Cells in the Endocrine System
Authors: Meghan Sara Adams
Marianne Bronner-Fraser
Publication date: 01-06-2009
Publisher: Humana Press Inc
Published in: Endocrine Pathology / Issue 2/2009
Print ISSN: 1046-3976
Electronic ISSN: 1559-0097
DOI: https://doi.org/10.1007/s12022-009-9070-6

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Other articles of this Issue 2/2009

The Cytology of a Thyroid Granular Cell Tumor

Small Cell Lung Cancer: Significance of RB Alterations and TTF-1 Expression in its Carcinogenesis, Phenotype, and Biology

A Comparative Study of Fine Needle Aspiration and Fine Needle Non-Aspiration Biopsy on Suspected Thyroid Nodules

MicroRNA Expression Profiles in Thyroid Tumors

Ectopic Growth Hormone-Releasing Hormone Secretion by a Neuroendocrine Tumor Causing Acromegaly: Long-Term Follow-Up Results

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