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European Journal of Nuclear Medicine and Molecular Imaging

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01-02-2011 | Image of the Month

Reversible brain hypometabolism associated with central nervous system systemic lupus erythematosus

Authors: Jukka Kemppainen, Sami Kajander, Timo Yli-Kerttula, Laura Airas, Marko Seppänen

Published in: European Journal of Nuclear Medicine and Molecular Imaging | Issue 2/2011

Excerpt

A 63-year-old woman with a history of hypothyroidism and rheumatoid arthritis was referred to the internal medicine department due to progressive muscle fatigue, weight loss of 15 kg, haemolytic anaemia, fever and memory impairment. The Mini-Mental State Examination was abnormal (MMSE 16/30). The initial brain MRI showed general cortical atrophy and FDG PET suggested a neurodegenerative disease with symmetrical severe hypometabolism in the frontal, parietal and temporal cortexes. Neurological consultation did not lead to a specific diagnosis. Later antinuclear antibody serological tests were indicative of systemic lupus erythematosus (SLE) [1‐5]. The patient was treated with high-dose corticosteroids and cyclophosphamide. …

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Otte A, Weiner SM, Peter HH, Mueller-Brand J, Goetze M, Moser E, et al. Brain glucose utilization in systemic lupus erythematosus with neuropsychiatric symptoms: a controlled positron emission tomography study. Eur J Nucl Med 1997;24(7):787–91.PubMed

Sailer M, Burchert W, Ehrenheim C, Smid HG, Haas J, Wildhagen K, et al. Positron emission tomography and magnetic resonance imaging for cerebral involvement in patients with systemic lupus erythematosus. J Neurol 1997;244(3):186–93.CrossRefPubMed

Weiner SM, Otte A, Schumacher M, Klein R, Gutfleisch J, Brink I, et al. Diagnosis and monitoring of central nervous system involvement in systemic lupus erythematosus: value of F-18 fluorodeoxyglucose PET. Ann Rheum Dis 2000;59(5):377–85.CrossRefPubMed

Title: Reversible brain hypometabolism associated with central nervous system systemic lupus erythematosus
Authors: Jukka Kemppainen
Sami Kajander
Timo Yli-Kerttula
Laura Airas
Marko Seppänen
Publication date: 01-02-2011
Publisher: Springer-Verlag
Published in: European Journal of Nuclear Medicine and Molecular Imaging / Issue 2/2011
Print ISSN: 1619-7070
Electronic ISSN: 1619-7089
DOI: https://doi.org/10.1007/s00259-010-1652-5

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Reversible brain hypometabolism associated with central nervous system systemic lupus erythematosus

Excerpt

Keynote webinar | Spotlight on medication adherence

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