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01-07-2008 | Basic Neurosciences, Genetics and Immunology - Original Article

Reversal of the expression pattern of Aldolase C mRNA in Purkinje cells and Ube 1x mRNA in Golgi cells by a dopamine D1 receptor agonist injections in the methamphetamine sensitized-rat cerebellum

Authors: Mitsuko Hamamura, Naotsugu Hirata, Kazuhiko Sawada, Takahide Shuto, Takao Shimazoe, Yoshihiro Terada, Yasuyuki Fukumaki

Published in: Journal of Neural Transmission | Issue 7/2008

Abstract

The cerebellum has a parasagittal modular structure, in which Zebrin (Aldolase) positive and negative bands expressed in Purkinje cell layers alternate, and is involved in amphetamine psychosis. Administration of SKF38393, a D1 receptor agonist, reversed the behavioral sensitization of methamphetamine. In the vermis, there were the binding sites of SKF38393. In methamphetamine-sensitized rats the expression of the Aldolase mRNA positive bands move laterally in the rat vermis. We provide here the evidence that the D1 agonist injections also reversed the expression pattern of both the Aldolase mRNA in Purkinje cells and Ube (ubiquitin activating enzyme) 1x mRNA in Golgi interneurons of the sensitized rats. Thus the reverse changes in gene expression pattern in the vermis may be involved in the mechanisms of the behavioral plasticity and suggests the new treatment of drug abuse.

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Title: Reversal of the expression pattern of Aldolase C mRNA in Purkinje cells and Ube 1x mRNA in Golgi cells by a dopamine D1 receptor agonist injections in the methamphetamine sensitized-rat cerebellum
Authors: Mitsuko Hamamura
Naotsugu Hirata
Kazuhiko Sawada
Takahide Shuto
Takao Shimazoe
Yoshihiro Terada
Yasuyuki Fukumaki
Publication date: 01-07-2008
Publisher: Springer Vienna
Published in: Journal of Neural Transmission / Issue 7/2008
Print ISSN: 0300-9564
Electronic ISSN: 1435-1463
DOI: https://doi.org/10.1007/s00702-008-0032-9

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Reversal of the expression pattern of Aldolase C mRNA in Purkinje cells and Ube 1x mRNA in Golgi cells by a dopamine D1 receptor agonist injections in the methamphetamine sensitized-rat cerebellum

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

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