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Behavioral and Brain Functions
Published in: Behavioral and Brain Functions 1/2018

Open Access 01-12-2018 | Research

Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM)

Authors: Shuhui Zhang, Xiaodong Liu, Mingzhu Sun, Qiuping Zhang, Teng Li, Xiang Li, Jia Xu, Xin Zhao, Dongyan Chen, Xizeng Feng

Published in: Behavioral and Brain Functions | Issue 1/2018

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Abstract

Background

With increased social pressure, individuals face a high risk of depression. Subsequently, depression affects cognitive behaviour and negatively impacts daily life. Fortunately, the Traditional Chinese Medicine Jia Wei Xiao Yao (JWXY) capsule is effective in reducing depression and improving cognitive behaviour.

Methods

The constituents of JWXY capsule were identified by ultra-performance liquid chromatography and quadrupole time-of-flight mass spectrometry analyses. We analysed behaviours of depression-like zebrafish in the novel tank with an automatic 3D video-tracking system and conducted the colour preference test, as well detected physiological changes after sertraline and JWXY capsule treatments.

Results

Both sertraline and JWXY capsule rescued the decreased locomotive behaviour and depression phenotype of zebrafish caused by reserpine. JWXY capsule especially improved the inhibited exploratory behaviour caused by reserpine. In addition, with the onset of depressive behaviour, zebrafish exhibited alterations in cognitive behaviour as indicated by colour preference changes. However, compared with sertraline, JWXY capsule was more efficaciously in rescuing this change in the colour preference pattern. Moreover, an increased level of cortisol, increased expression of tyrosine hydroxylase (TH) and decreased monoamine neurotransmitters, including serotonin (5-HT) and noradrenaline, were involved in the depressive behaviours. In addition, sertraline and JWXY capsule rescued the depressive phenotype and cognitive behaviour of zebrafish by altering the levels of endogenous cortisol and monoamine neurotransmitters.

Conclusions

JWXY capsule was more effectively than sertraline in rescuing reserpine-induced depression and cognitive disorder in zebrafish. Potentially, our study can provide new insights into the clinical treatment of depression and the mechanism of action of JWXY capsule.
Appendix
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Metadata
Title
Reversal of reserpine-induced depression and cognitive disorder in zebrafish by sertraline and Traditional Chinese Medicine (TCM)
Authors
Shuhui Zhang
Xiaodong Liu
Mingzhu Sun
Qiuping Zhang
Teng Li
Xiang Li
Jia Xu
Xin Zhao
Dongyan Chen
Xizeng Feng
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Behavioral and Brain Functions / Issue 1/2018
Electronic ISSN: 1744-9081
DOI
https://doi.org/10.1186/s12993-018-0145-8

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