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Current Hypertension Reports
Published in: Current Hypertension Reports 4/2013

Open Access 01-08-2013 | Hypertension and the Heart (PW de Leeuw and AH Gradman, Section Editors)

Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension

Authors: Julian F. R. Paton, Laura Ratcliffe, Dagmara Hering, Jacek Wolf, Paul A. Sobotka, Krzysztof Narkiewicz

Published in: Current Hypertension Reports | Issue 4/2013

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Abstract

Much recent attention has been given to the carotid body because of its potential role in cardiovascular disease states. One disease, neurogenic hypertension, characterised by excessive sympathetic activity, appears dependent on carotid body activity that may or may not be accompanied by sleep-disordered breathing. Herein, we review recent literature suggesting that the carotid body acquires tonicity in hypertension. We predict that carotid glomectomy will be a powerful way to temper excessive sympathetic discharge in diseases such as hypertension. We propose a model to explain that signalling from the ‘hypertensive’ carotid body is tonic, and hypothesise that there will be a sub-population of glomus cells that channel separately into reflex pathways controlling sympathetic motor outflows.
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Metadata
Title
Revelations About Carotid Body Function Through its Pathological Role in Resistant Hypertension
Authors
Julian F. R. Paton
Laura Ratcliffe
Dagmara Hering
Jacek Wolf
Paul A. Sobotka
Krzysztof Narkiewicz
Publication date
01-08-2013
Publisher
Springer US
Published in
Current Hypertension Reports / Issue 4/2013
Print ISSN: 1522-6417
Electronic ISSN: 1534-3111
DOI
https://doi.org/10.1007/s11906-013-0366-z

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