Published in:
01-09-2014 | Research Article
RETRACTED ARTICLE: Relationships between genetic polymorphisms in
inflammation-related factor gene and the pathogenesis of nasopharyngeal
cancer
Authors:
Yan-Li Qu, Hong Yu, Yan-Zhi Chen, Yu-Xia Zhao, Guang-Jun Chen, Lu Bai, Dan Liu, Hong-Xin Su, He-Tong Wang
Published in:
Tumor Biology
|
Issue 9/2014
Login to get access
Abstract
Our study aims to discuss the association between inflammation-related factors
such as single nucleotide polymorphisms (SNPs) with susceptibility and recurrence in
nasopharyngeal carcinoma. We used Taqman real-time polymerase chain reaction (PCR)
to characterize the genetic variation of five SNPs in 194 nasopharyngeal carcinoma
patients and 231 healthy subjects. All statistical analysis is performed with
statistical product and service solutions v13.0; odds ratio (OR) value and 95 %
confidence interval (CI) were calculated. There is no relationship between TGFβ1 –869 T/C, IL-6 –634C/G, TGFβ1 –509C/T, IL1
–511C/T and nasopharyngeal carcinoma susceptibility. Both single factor and multiple
factors analysis showed that IL1a –889 T/T
genotype is significantly associated with nasopharyngeal carcinoma in decreasing the
risk of nasopharyngeal carcinoma. A highly significant association was found between
IL1a –889 T/T genotype and protective
genotype as defined by various pathological types. This is more obvious in the
protective genotype of the non-keratin-type squamous carcinoma undifferentiated
type. We also discovered that genotype G/G and C/G + G/G of IL6 –634 gene are associated with reduced recurrence of
nasopharyngeal carcinoma. IL1a –889 gene
polymorphism and susceptibility is related to nasopharyngeal carcinoma and can
potentially decrease the risk of nasopharyngeal carcinoma in the Han Chinese
population in north China. IL1-889 TT genotype is protective genotype for
nasopharyngeal carcinoma. We have provided evidence that the GG genotype of the
IL6 –634 gene is associated with recurrent
risk of nasopharyngeal carcinoma. The G allele is the protective gene of
nasopharyngeal carcinoma recurrence.