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European Journal of Medical Research

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Open Access 01-12-2013 | Research

RETRACTED ARTICLE: Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms

Authors: Yu Wang, Xiaorong Bao

Published in: European Journal of Medical Research | Issue 1/2013

Abstract

Background

An increase in serum uric acid (UA) occurs during the early and middle stages of chronic kidney disease (CKD) and aggravates the deterioration of kidney function. This study aims to explore the relation between UA and endothelial dysfunction in early CKD and its mechanisms in a murine model.

Methods

The experimental animals were randomly divided into three groups (n = 10): sham-operation group (control group), right nephrectomy only group (CKD group) and right nephrectomy with oxonic potassium group (CKD with hyperuricemia group). Furthermore, we analyzed the relation between UA and endothelial dysfunction indices in early CKD as well as its mechanisms.

Results

Linear regression analysis showed that the level of serum UA had a significant positive correlation with serum endothelin-1 and the percentage of collagen I positive area, but a negative correlation with serum nitric oxide (NO) and NO/endothelin-1 ratio. In addition, the level of serum UA had significant positive correlations with serum malonaldehyde, serum C-reactive protein, serum oxidatively-modified low-density lipoprotein and serum low-density lipoprotein, but a negative correlation with serum superoxide dismutase.

Conclusions

Endothelial dysfunction in the CKD group was significant and had a positive correlation with the level of serum UA. Endothelial dysfunction in early CKD with hyperuricemia is perhaps related to oxidative stress, micro-inflammation and lipid oxidation.

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Title: RETRACTED ARTICLE: Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms
Authors: Yu Wang
Xiaorong Bao
Publication date: 01-12-2013
Publisher: BioMed Central
Published in: European Journal of Medical Research / Issue 1/2013
Electronic ISSN: 2047-783X
DOI: https://doi.org/10.1186/2047-783X-18-26

Keynote webinar | Spotlight on medication adherence

Springer Medicine

RETRACTED ARTICLE: Effects of uric acid on endothelial dysfunction in early chronic kidney disease and its mechanisms

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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