Published in:
Open Access 01-12-2015 | Research
RETRACTED ARTICLE: Dual loading miR-218 mimics and Temozolomide using AuCOOH@FA-CS drug delivery system: promising targeted anti-tumor drug delivery system with sequential release functions
Published in: Journal of Experimental & Clinical Cancer Research | Issue 1/2015
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Background
Dual loading drug delivery system with tumor targeting efficacy and
sequential release function provides a promising platform for anticancer drug
delivery. Herein, we established a novel AuCOOH@FACS nanogel system for
co-delivery miR-218 mimics (as bio-drug) and Temozolomide(as chemo-drug).
Methods
DLS and TEM were employed to determine the characteristics of
particles and nanogels. The cell viability was calculated for study synergistic
effect of both drugs coadministration and in nanogel forms. The amounts of Au
uptake were measured by ICP-MS in cell and tumors to quantify the targeting drug
delivery efficacy. Tumor weight and mice weight were investigated to study the
targeting antitumor efficacy of nanogel system.
Results
The results revealed that using AuCOOH@FACS nanogel as delivery
vehicles, drugs could be targeting delivery to tumor site, the intracellular
uptake is enhanced to a greater extent, and significant antitumor efficacy is fold
increase compared with free drug administration group, without noticeable system
cytotoxicity.
Conclusions
This system offers an efficient approach to cancer therapy and holds
significant potential to improve the treatment of cancer in the future.