Published in:
01-01-2014 | Research Article
RETRACTED ARTICLE: Association of XRCC1 gene single nucleotide polymorphisms and susceptibility to pancreatic cancer in Chinese
Authors:
Hongxu Chen, Chun Tang, Menggang Liu, Bo Zhou, Yi Kuang, Tao Yuan, Ping Chen
Published in:
Tumor Biology
|
Issue 1/2014
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Abstract
The human X-ray repair cross-complementing group 1 gene (XRCC1) is an important candidate gene for affecting pancreatic cancer (PC) risk. The objective of this study was to detect whether the c.1471G > A and c.1686C > G polymorphisms of XRCC1 gene influence PC risk. The association of XRCC1 genetic variants with PC risk was analyzed in 328 PC patients and 350 controls by the polymerase chain reaction-restriction fragment length polymorphism and created restriction site-polymerase chain reaction method. Our data suggested that the genotypes and alleles from these two genetic variants were statistically associated with PC risk. For c.1471G > A, the AA genotype was associated with the decreased risk of developing PC compared to GG wild genotype (odds ratio (OR) = 0.43, 95 % confidence intervals (CI) 0.26–0.70, chi-squared (χ
2) = 11.91, P = 0.001). For c.1686C > G, the risk of PC was significantly lower for GG genotype in comparing to CC wild genotype (OR = 0.48, 95 % CI 0.29–0.81, χ
2 = 7.98, P = 0.005). The A allele of c.1471G > A and G allele of c.1686C > G genetic variants could contribute to decrease the risk of PC (for c.1471G > A: A vs G, OR = 0.65, 95 % CI 0.52–0.82, χ
2 = 13.71, P < 0.001, for c.1686C > G: G vs C, OR = 0.70, 95 % CI 0.55–0.88, χ
2 = 9.42, P = 0.002). Our findings indicate that the c.1471G > A and c.1686C > G polymorphisms of XRCC1 gene are associated with PC risk in Chinese population.