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Child's Nervous System

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01-05-2007 | Original Paper

Retinoic acid-induced lumbosacral neural tube defects: myeloschisis and hamartoma

Authors: WeiSong Cai, HongYu Zhao, JunBin Guo, Yong Li, ZhengWei Yuan, WeiLin Wang

Published in: Child's Nervous System | Issue 5/2007

Abstract

Objects

To observe the morphological features of the lumbosacral neural tube defects (NTDs) induced by all-trans retinoic acid (atRA) and to explore the pathogenesis of these defects.

Methods

Rat embryos with lumbosacral NTDs were obtained by treating pregnant rats with administration of atRA. Rat embryos were obtained by cesarean. Fetuses were sectioned and stained with hematoxylin–eosin (H&E). Relevant structures including caudal neural tube were examined. In the atRA-treated rats, about 48% embryos showed lumbosacral NTDs. There appeared a dorsally and rostrally situated, neural-plate-like structure (myeloschisis) and a ventrally and caudally located cell mass containing multiple canals (hamartoma) in the lumbosacral NTDs induced by atRA.

Conclusions

Retinoic acid could disturb the notochord and tail bud development in the process of primary and secondary neurulation in rat embryos, which cause lumbosacral NTDs including myeloschisis and hamartoma. The morphology is very similar to that happens in humans.

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Title: Retinoic acid-induced lumbosacral neural tube defects: myeloschisis and hamartoma
Authors: WeiSong Cai
HongYu Zhao
JunBin Guo
Yong Li
ZhengWei Yuan
WeiLin Wang
Publication date: 01-05-2007
Publisher: Springer-Verlag
Published in: Child's Nervous System / Issue 5/2007
Print ISSN: 0256-7040
Electronic ISSN: 1433-0350
DOI: https://doi.org/10.1007/s00381-006-0289-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Retinoic acid-induced lumbosacral neural tube defects: myeloschisis and hamartoma

Abstract

Objects

Methods

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Objects

Methods

Conclusions

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