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Annals of General Psychiatry
Published in: Annals of General Psychiatry 1/2010

Open Access 01-04-2010 | Meeting abstract

Results of a new cognitive method in rats on the Morris water maze used in modeling experimental Alzheimer's disease

Authors: Katalin Megyeri, Mihály Albert, István Gacsályi

Published in: Annals of General Psychiatry | Special Issue 1/2010

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Excerpt

In Alzheimer's disease (AD) the loss of neurons in the hippocampal CA3 regions is present. In rats treated by sodium azide (NaN3) via subcutaneously implanted osmotic minipumps number of CA3 cells were decreased [1]. We developed a new method to produce AD-like dementia using single intracerebrally (ic.) injected NaN3 in rats. …
Literature
1.
Bennett MC: Chronic in vivo sodium azide infusion induces selective and stable inhibition of cytochrome c oxidase. J Neurochem. 1996, 66: 2606-2611.CrossRefPubMed
2.
Bennett MC: Chronic sodium azide treatment impairs learning of the Morris water maze task. Behav Neural Biol. 1992, 58: 72-75. 10.1016/0163-1047(92)90967-9.CrossRefPubMed
Metadata
Title
Results of a new cognitive method in rats on the Morris water maze used in modeling experimental Alzheimer's disease
Authors
Katalin Megyeri
Mihály Albert
István Gacsályi
Publication date
01-04-2010
Publisher
BioMed Central
Published in
Annals of General Psychiatry / Issue Special Issue 1/2010
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/1744-859X-9-S1-S92

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