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Annals of Surgical Oncology
Published in: Annals of Surgical Oncology 8/2016

01-08-2016 | Head and Neck Oncology

Results and Survival of Locally Advanced AJCC 7th Edition T4a Laryngeal Squamous Cell Carcinoma Treated with Primary Total Laryngectomy and Postoperative Radiotherapy

Authors: Philippe Gorphe, MD, MSc, Margarida Matias, MD, Antoine Moya-Plana, MD, MSc, Florian Tabarino, MD, Pierre Blanchard, MD, PhD, Yungan Tao, MD, PhD, François Janot, MD, Stéphane Temam, MD, PhD

Published in: Annals of Surgical Oncology | Issue 8/2016

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Abstract

Purpose

The objective of this study was to analyze the results and survival of patients with T4a laryngeal squamous cell carcinoma (SCC) treated, according to clinical practice guidelines, with total laryngectomy and postoperative radiotherapy (TL–PORT) in a large and homogeneous series.

Methods

Initial staging assessment, treatment details, pathologic features, follow-up, and patterns of recurrence were retrospectively reviewed in a large series of 100 patients treated in our center between 2001 and 2013 for T4a laryngeal SCC with TL–PORT.

Results

Two-, 5-, and 10-year overall survival rates were 65, 52.4, and 33.3 %, respectively, while 2-, 5-, and 10-year disease-free survival rates were 55, 42.6, and 31.8 %, respectively. In addition, 2-, 5-, and 10-year locoregional control rates were 77, 74, and 65.9 %, respectively. Central lymph node involvement was associated with pathologic subglottic extension (p = 0.01), lysis of the cricoid cartilage (p = 0.03), and tracheal extension (p = 0.02). Extracapsular spread of central lymph node metastases, the main prognostic factor identified by multivariate analysis, was associated with decreased locoregional control and survival rates.

Conclusion

In this homogenously treated cohort, with consistent guideline application, surgery for T4a larynx cancer remains a standard of care, with current results used as a benchmark.
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Metadata
Title
Results and Survival of Locally Advanced AJCC 7th Edition T4a Laryngeal Squamous Cell Carcinoma Treated with Primary Total Laryngectomy and Postoperative Radiotherapy
Authors
Philippe Gorphe, MD, MSc
Margarida Matias, MD
Antoine Moya-Plana, MD, MSc
Florian Tabarino, MD
Pierre Blanchard, MD, PhD
Yungan Tao, MD, PhD
François Janot, MD
Stéphane Temam, MD, PhD
Publication date
01-08-2016
Publisher
Springer International Publishing
Published in
Annals of Surgical Oncology / Issue 8/2016
Print ISSN: 1068-9265
Electronic ISSN: 1534-4681
DOI
https://doi.org/10.1245/s10434-016-5217-0

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