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Annals of General Psychiatry
Published in: Annals of General Psychiatry 1/2018

Open Access 01-12-2018 | Primary research

Resting-state brain activity in Chinese boys with low functioning autism spectrum disorder

Authors: Gaizhi Li, Kathryn Rossbach, Wenqing Jiang, Yasong Du

Published in: Annals of General Psychiatry | Issue 1/2018

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Abstract

Background

This study aimed to explore the resting-state fMRI changes in Chinese boys with low functioning autism spectrum disorder (LFASD) and the correlation with clinical symptoms.

Methods

The current study acquired resting-state fMRI data from 15 Chinese boys with LFASD and 15 typically developing (TD) boys to examine the local brain activity using the regional homogeneity (ReHo) and amplitude of low-frequency fluctuation (ALFF) indexes; the researchers also examined these measures and their possible relationships with clinical symptoms using the autism behavior checklist.

Results

Results indicated that boys with LFASD exhibited increased ReHo in the right precuneus and inferior parietal gyrus (IPG), increased ALFF in right middle temporal gyrus, angular gyrus and IPG. However, no correlation was found between the ALFF/ReHo score and clinical symptoms in the LFASD group.

Conclusions

Some of the brain regions had ReHo/ALFF values that were higher in the boys with LFASD than the TD group and these differentiated brain areas in boys with LFASD were all on the right cerebrum, which supported ‘atypical rightward asymmetry’ in boys with LFASD.
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Metadata
Title
Resting-state brain activity in Chinese boys with low functioning autism spectrum disorder
Authors
Gaizhi Li
Kathryn Rossbach
Wenqing Jiang
Yasong Du
Publication date
01-12-2018
Publisher
BioMed Central
Published in
Annals of General Psychiatry / Issue 1/2018
Electronic ISSN: 1744-859X
DOI
https://doi.org/10.1186/s12991-018-0217-z

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