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Health and Quality of Life Outcomes
Published in: Health and Quality of Life Outcomes 1/2011

Open Access 01-12-2011 | Research

Responsiveness of EORTC QLQ-C30, QLQ-CR38 and FACT-C quality of life questionnaires in patients with colorectal cancer

Authors: Lionel Uwer, Christine Rotonda, Francis Guillemin, Joëlle Miny, Marie-Christine Kaminsky, Mariette Mercier, Laetitia Tournier-Rangeard, Isabelle Leonard, Philippe Montcuquet, Philippe Rauch, Thierry Conroy

Published in: Health and Quality of Life Outcomes | Issue 1/2011

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Abstract

Background

The aim of this study was to compare the responsiveness of the European Organization for Research and Treatment (EORTC) quality of life questionnaires (QLQ-C30, QLQ-CR38) and the Functional Assessment of Cancer Therapy-colorectal version 4 questionnaire (FACT-C).

Method

This prospective study included 127 patients with colorectal cancer: 71 undergoing chemotherapy and 56 radiation therapy. Responsiveness statistics included the Standardized Response Mean (SRM) and the Effect Size (ES). The patient's overall assessment of his/her change in state of health status was the reference criterion to evaluate the responsiveness of the QoL questionnaires.

Results

34 patients perceived their health as stable and 17 as improved between the first and the fourth courses of chemotherapy. 21 patients perceived their health as stable and 22 as improved between before and the last week of radiotherapy.
The responsiveness of the 3 questionnaires differed according to treatments. The EORTC QLQ-C30 questionnaire was more responsive in patients receiving chemotherapy, particulary functional scales (SRM > 0.55). The QLQ-CR38 and the FACT-C questionnaires provided little clinically relevant information during chemotherapy or radiotherapy.

Conclusion

The EORTC QLQ-C30 questionnaire appears to be more responsive in patients receiving chemotherapy.
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Metadata
Title
Responsiveness of EORTC QLQ-C30, QLQ-CR38 and FACT-C quality of life questionnaires in patients with colorectal cancer
Authors
Lionel Uwer
Christine Rotonda
Francis Guillemin
Joëlle Miny
Marie-Christine Kaminsky
Mariette Mercier
Laetitia Tournier-Rangeard
Isabelle Leonard
Philippe Montcuquet
Philippe Rauch
Thierry Conroy
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Health and Quality of Life Outcomes / Issue 1/2011
Electronic ISSN: 1477-7525
DOI
https://doi.org/10.1186/1477-7525-9-70

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