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Open Access 01-12-2021 | Respiratory Syncytial Virus Infection | Research article

Respiratory syncytial virus in severe lower respiratory infections in previously healthy young Ethiopian infants

Authors: Abate Yeshidinber Weldetsadik, Frank Riedel

Published in: BMC Pediatrics | Issue 1/2021

Abstract

Background

Respiratory Syncytial Virus (RSV) is the commonest cause of acute lower respiratory infections (ALRI) in infants. However, the burden of RSV is unknown in Ethiopia. We aimed to determine the prevalence, seasonality and predictors of RSV infection in young infants with ALRI for the first time in Ethiopia.

Methods

We performed RSV immuno-chromatographic assay from nasopharyngeal swabs of infants, 29 days to 6 months of age. We included the first 10 eligible infants in each month from June 2018 to May 2019 admitted in a tertiary pediatric center. Clinical, laboratory and imaging data were also collected, and chi-square test and regression were used to assess associated factors with RSV infection.

Results

Among a total of 117 study children, 65% were male and mean age was 3 months. Bronchiolitis was the commonest diagnosis (49%). RSV was isolated from 26 subjects (22.2%) of all ALRI, 37% of bronchiolitis and 11% of pneumonia patients. Although RSV infection occurred year round, highest rate extended from June to November. No clinical or laboratory parameter predicted RSV infection and only rainy season (Adjusted Odds Ratio (AOR) 10.46 [95%. C.I. 1.95, 56.18]) was independent predictor of RSV infection.

Conclusions

RSV was isolated in a fifth of young infants with severe ALRI, mostly in the rainy season. Diagnosis of RSV infection in our setting require specific tests as no clinical parameter predicted RSV infection. Since RSV caused less than a quarter of ALRI in our setting, the other causes should be looked for in future studies.

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Title: Respiratory syncytial virus in severe lower respiratory infections in previously healthy young Ethiopian infants
Authors: Abate Yeshidinber Weldetsadik
Frank Riedel
Publication date: 01-12-2021
Publisher: BioMed Central
Keywords: Respiratory Syncytial Virus Infection
Pneumonia
Bronchiolitis
Published in: BMC Pediatrics / Issue 1/2021
Electronic ISSN: 1471-2431
DOI: https://doi.org/10.1186/s12887-021-02675-3

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Respiratory syncytial virus in severe lower respiratory infections in previously healthy young Ethiopian infants

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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