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European Journal of Clinical Microbiology & Infectious Diseases

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Open Access 01-12-2019 | Respiratory Syncytial Virus Infection | Original Article

Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey

Authors: Wen-Kuan Liu, De-Hui Chen, Wei-Ping Tan, Shu-Yan Qiu, Duo Xu, Li Zhang, Shu-Jun Gu, Rong Zhou, Qian Liu

Published in: European Journal of Clinical Microbiology & Infectious Diseases | Issue 12/2019

Abstract

To investigate the features of paramyxovirus respiratory syncytial virus (RSV), parainfluenza virus (PIV), and human metapneumovirus (HMPV) infection and determine the effect of meteorological conditions in Guangzhou, a subtropical region of southern China. We collected 11,398 respiratory samples from hospitalized pediatric patients with acute respiratory illness between July 2009 and June 2016 in Guangzhou. The samples were tested simultaneously for 18 respiratory pathogens using real-time PCR. Local meteorological data were also collected for correlation analysis. Of 11,398 patients tested, 5606 (49.2%) patients tested positive for one or more pathogens; RSV, PIV, and HMPV were the first, sixth, and ninth most frequently detected pathogens, in 1690 (14.8%), 502 (4.4%), and 321 (2.8%) patients, respectively. A total 17.9% (4605/5606) of patients with positive results had coinfection with other pathogens. Significant differences were found in the prevalence of RSV, PIV, and HMPV among all age groups (p < 0.001). RSV and HMPV had similar seasonal patterns, with two prevalence peaks every year. PIV appeared alternatively with RSV and HMPV. Multiple linear regression models were established for RSV, PIV, and HMPV prevalence and meteorological factors (p < 0.05). RSV and PIV incidence was negatively correlated with monthly mean relative humidity; RSV and HMPV incidence was negatively correlated with sunshine duration; PIV incidence was positively correlated with mean temperature. We described the features of paramyxovirus infection in a subtropical region of China and highlighted the correlation with meteorological factors. These findings will assist public health authorities and clinicians in improving strategies for controlling paramyxovirus infection.

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Title: Paramyxoviruses respiratory syncytial virus, parainfluenza virus, and human metapneumovirus infection in pediatric hospitalized patients and climate correlation in a subtropical region of southern China: a 7-year survey
Authors: Wen-Kuan Liu
De-Hui Chen
Wei-Ping Tan
Shu-Yan Qiu
Duo Xu
Li Zhang
Shu-Jun Gu
Rong Zhou
Qian Liu
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Keywords: Respiratory Syncytial Virus Infection
Chlamydophila Pneumoniae
Published in: European Journal of Clinical Microbiology & Infectious Diseases / Issue 12/2019
Print ISSN: 0934-9723
Electronic ISSN: 1435-4373
DOI: https://doi.org/10.1007/s10096-019-03693-x

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