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BMC Infectious Diseases
Published in: BMC Infectious Diseases 1/2024

Open Access 01-12-2024 | Respiratory Syncytial Virus Infection | Research

Respiratory syncytial virus subtypes in children with bronchiolitis: does it correlate with clinical severity?

Authors: Shuo Yang, Sukun Lu, Yakun Wang, Yinghui Guo, Zhuang Zhang, Weijian Wang, Le Wang

Published in: BMC Infectious Diseases | Issue 1/2024

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Abstract

Background

In this retrospective study, we aimed to evaluate the factors associated with the severity of respiratory syncytial virus (RSV) bronchiolitis in children aged under 2 years who were admitted to the Children’s Hospital of Hebei between June 2018 and January 2019.

Methods

Sputum samples positive for RSV via multiplex PCR were subtyped using real-time PCR. Data collected included risk factors for disease severity, demographics, microbiology, and outcomes.

Results

Of the 82 children with RSV bronchiolitis, 79 were treated and discharged with improvement, while 3 died. All three patients had underlying medical conditions, including complex congenital heart disease and severe combined immunodeficiency. Further, disease severity was associated with preexisting underlying disease, fever duration, and bacterial co-infection, but not with the RSV subtype.

Conclusions

Our findings suggest that an appropriate therapeutic regimen should include the detection of bacterial co-infections and the identification of underlying diseases for the effective management of severe RSV bronchiolitis.
Literature
1.
Shay DK, Holman RC, Newman RD, Liu LL, Stout JW, Anderson LJ. Bronchiolitis-associated hospitalizations among US children, 1980–1996. JAMA. 1999;282(15):1440–6.PubMedCrossRef
2.
3.
Collaborators GBDLRI. Estimates of the global, regional, and national morbidity, mortality, and aetiologies of lower respiratory infections in 195 countries, 1990–2016: a systematic analysis for the global burden of Disease Study 2016. Lancet Infect Dis. 2018;18(11):1191–210.CrossRef
4.
Shi T, McAllister DA, O’Brien KL, Simoes EAF, Madhi SA, Gessner BD, Polack FP, Balsells E, Acacio S, Aguayo C, et al. Global, regional, and national disease burden estimates of acute lower respiratory infections due to respiratory syncytial virus in young children in 2015: a systematic review and modelling study. Lancet. 2017;390(10098):946–58.PubMedPubMedCentralCrossRef
5.
Omer SB, Bednarczyk R, Kazi M, Guterman LB, Aziz F, Allen KE, Yildirim I, Ali SA. Assessment and Validation of Syndromic Case definitions for respiratory Syncytial Virus Testing in a low Resource Population. Pediatr Infect Dis J. 2019;38(3):e57–9.PubMedCrossRef
6.
O’Brien S, Borland ML, Cotterell E, Armstrong D, Babl F, Bauert P, Brabyn C, Garside L, Haskell L, Levitt D, et al. Australasian bronchiolitis guideline. J Paediatr Child Health. 2019;55(1):42–53.PubMedCrossRef
7.
Diseases NCMRCR. Chinese experts′ consensus statement on diagnosis, treatment and prevention of respiratory syncytial virus infection in children. Chin J Practical Paediatrics. 2020;35(4):241–50.
8.
Ralston SL, Lieberthal AS, Meissner HC, Alverson BK, Baley JE, Gadomski AM, Johnson DW, Light MJ, Maraqa NF, Mendonca EA, et al. Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis. Pediatrics. 2014;134(5):e1474–1502.PubMedCrossRef
9.
10.
Rosas-Salazar C, Chirkova T, Gebretsadik T, Chappell JD, Peebles RS Jr., Dupont WD, Jadhao SJ, Gergen PJ, Anderson LJ, Hartert TV. Respiratory syncytial virus infection during infancy and asthma during childhood in the USA (INSPIRE): a population-based, prospective birth cohort study. Lancet. 2023;401(10389):1669–80.PubMedCrossRef
11.
Driscoll AJ, Arshad SH, Bont L, Brunwasser SM, Cherian T, Englund JA, Fell DB, Hammitt LL, Hartert TV, Innis BL, et al. Does respiratory syncytial virus lower respiratory illness in early life cause recurrent wheeze of early childhood and asthma? Critical review of the evidence and guidance for future studies from a World Health Organization-sponsored meeting. Vaccine. 2020;38(11):2435–48.PubMedPubMedCentralCrossRef
12.
Domachowske J, Halczyn J, Bonville CA. Preventing Pediatric respiratory syncytial virus infection. Pediatr Ann. 2018;47(9):e371–6.PubMedCrossRef
13.
Soto JA, Galvez NMS, Pacheco GA, Bueno SM, Kalergis AM. Antibody development for preventing the human respiratory syncytial virus pathology. Mol Med. 2020;26(1):35.PubMedPubMedCentralCrossRef
14.
Midulla F, Nenna R, Scagnolari C, Petrarca L, Frassanito A, Viscido A, Arima S, Antonelli G, Pierangeli A. How respiratory syncytial virus genotypes influence the clinical course in infants hospitalized for Bronchiolitis. J Infect Dis. 2019;219(4):526–34.PubMedCrossRef
15.
Laham FR, Mansbach JM, Piedra PA, Hasegawa K, Sullivan AF, Espinola JA, Camargo CA Jr. Clinical profiles of respiratory Syncytial Virus subtypes a AND B among Children hospitalized with Bronchiolitis. Pediatr Infect Dis J. 2017;36(8):808–10.PubMedPubMedCentralCrossRef
16.
Papadopoulos NG, Gourgiotis D, Javadyan A, Bossios A, Kallergi K, Psarras S, Tsolia MN, Kafetzis D. Does respiratory syncytial virus subtype influences the severity of acute bronchiolitis in hospitalized infants? Respir Med. 2004;98(9):879–82.PubMedCrossRef
17.
Anderson EJ, Carbonell-Estrany X, Blanken M, Lanari M, Sheridan-Pereira M, Rodgers-Gray B, Fullarton J, Rouffiac E, Vo P, Notario G, et al. Burden of severe respiratory Syncytial Virus Disease among 33–35 weeks’ gestational age infants born during multiple respiratory Syncytial Virus Seasons. Pediatr Infect Dis J. 2017;36(2):160–7.PubMedPubMedCentralCrossRef
18.
Hall CB, Weinberg GA, Blumkin AK, Edwards KM, Staat MA, Schultz AF, Poehling KA, Szilagyi PG, Griffin MR, Williams JV, et al. Respiratory syncytial virus-associated hospitalizations among children less than 24 months of age. Pediatrics. 2013;132(2):e341–348.PubMedCrossRef
19.
Wang L, Yang S, Yan X, Liu T, Feng Z, Li G. Comparing the yield of oropharyngeal swabs and sputum for detection of 11 common pathogens in hospitalized children with lower respiratory tract infection. Virol J. 2019;16(1):84.PubMedPubMedCentralCrossRef
20.
Hall CB. The burgeoning burden of respiratory syncytial virus among children. Infect Disord Drug Targets. 2012;12(2):92–7.PubMedCrossRef
21.
Smith M, Kubale J, Kuan G, Ojeda S, Vydiswaran N, Sanchez N, Gresh L, Latta K, Lopez R, Patel M, et al. Respiratory Syncytial Virus incidence and severity in a community-based prospective cohort of children aged 0–14 years. Open Forum Infect Dis. 2022;9(11):ofac598.PubMedPubMedCentralCrossRef
22.
Fan R, Fan C, Zhang J, Wen B, Lei Y, Liu C, Chen L, Liu W, Wang C, Qu X. Respiratory syncytial virus subtype ON1/NA1/BA9 predominates in hospitalized children with lower respiratory tract infections. J Med Virol. 2017;89(2):213–21.PubMedCrossRef
23.
Chen X, Xu B, Guo J, Li C, An S, Zhou Y, Chen A, Deng L, Fu Z, Zhu Y, et al. Genetic variations in the fusion protein of respiratory syncytial virus isolated from children hospitalized with community-acquired pneumonia in China. Sci Rep. 2018;8(1):4491.ADSPubMedPubMedCentralCrossRef
24.
Tabor DE, Fernandes F, Langedijk AC, Wilkins D, Lebbink RJ, Tovchigrechko A, Ruzin A, Kragten-Tabatabaie L, Jin H, Esser MT et al. Global Molecular Epidemiology of respiratory Syncytial Virus from the 2017–2018 INFORM-RSV study. J Clin Microbiol 2020, 59(1).
25.
Bandla SS, Devadiga S, Bhatt R, Dsa OC, Govindakarnavar A. Molecular epidemiology of respiratory syncytial virus among children and adults in India 2016 to 2018. Virus Genes. 2021;57(6):489–501.PubMedPubMedCentralCrossRef
26.
Ren L, Lin L, Zhang H, Wang Q, Cheng Y, Liu Q, Fang B, Xie L, Wang M, Yang J, et al. Epidemiological and clinical characteristics of respiratory syncytial virus and influenza infections in hospitalized children before and during the COVID-19 pandemic in Central China. Influenza Other Respir Viruses. 2023;17(2):e13103.PubMedPubMedCentralCrossRef
27.
Lin TY, Chi H, Kuo CY, Tsai HP, Wang JR, Liu CC, Shen CF. Outbreak of respiratory syncytial virus subtype ON1 among children during COVID-19 pandemic in Southern Taiwan. J Microbiol Immunol Infect. 2022;55(6 Pt 2):1168–79.PubMedCrossRef
28.
Martinello RA, Chen MD, Weibel C, Kahn JS. Correlation between respiratory syncytial virus genotype and severity of illness. J Infect Dis. 2002;186(6):839–42.PubMedCrossRef
29.
Neves Barreira J, Fonseca C, Cardoso M, Azevedo A, Bonito Vitor A. [Relationship between respiratory syncytial virus subtype and clinical severity in bronchiolitis]. Esp Pediatr. 2001;54(6):559–66.CrossRef
30.
Esposito S, Salice P, Bosis S, Ghiglia S, Tremolati E, Tagliabue C, Gualtieri L, Barbier P, Galeone C, Marchisio P, et al. Altered cardiac rhythm in infants with bronchiolitis and respiratory syncytial virus infection. BMC Infect Dis. 2010;10:305.PubMedPubMedCentralCrossRef
31.
32.
Casalegno JS. [RSV and associated diseases]. Rev Prat. 2022;72(8):5–7.PubMed
33.
Kawashima H, Inagaki N, Nakayama T, Morichi S, Nishimata S, Yamanaka G, Kashiwagi Y. Cardiac complications caused by respiratory syncytial virus infection: Questionnaire Survey and a literature review. Glob Pediatr Health. 2021;8:2333794X211044114.PubMedPubMedCentral
34.
Thorburn K, Eisenhut M, Shauq A, Narayanswamy S, Burgess M. Right ventricular function in children with severe respiratory syncytial virus (RSV) bronchiolitis. Minerva Anestesiol. 2011;77(1):46–53.PubMed
35.
Arias AV, Lucas DJ, Shafi NI. Respiratory Syncytial Virus Bronchiolitis complicated by necrotizing enterocolitis: a Case Series. Pediatrics 2021, 147(5).
36.
Saravanos GL, King CL, Deng L, Dinsmore N, Ramos I, Takashima M, Crawford N, Clark JE, Dale RC, Jones CA, et al. Respiratory Syncytial Virus-Associated neurologic complications in children: a systematic review and aggregated Case Series. J Pediatr. 2021;239:39–49e39.PubMedCrossRef
37.
Peres Bota D, Lopes Ferreira F, Melot C, Vincent JL. Body temperature alterations in the critically ill. Intensive Care Med. 2004;30(5):811–6.PubMedCrossRef
38.
39.
Schulman CI, Namias N, Doherty J, Manning RJ, Li P, Elhaddad A, Lasko D, Amortegui J, Dy CJ, Dlugasch L, et al. The effect of antipyretic therapy upon outcomes in critically ill patients: a randomized, prospective study. Surg Infect (Larchmt). 2005;6(4):369–75.PubMedCrossRef
40.
Larranaga CL, Ampuero SL, Luchsinger VF, Carrion FA, Aguilar NV, Morales PR, Palomino MA, Tapia LF, Avendano LF. Impaired immune response in severe human lower tract respiratory infection by respiratory syncytial virus. Pediatr Infect Dis J. 2009;28(10):867–73.PubMedCrossRef
41.
O’Donnell DR, Carrington D. Peripheral blood lymphopenia and neutrophilia in children with severe respiratory syncytial virus disease. Pediatr Pulmonol. 2002;34(2):128–30.PubMedCrossRef
42.
Johnson JE, Gonzales RA, Olson SJ, Wright PF, Graham BS. The histopathology of fatal untreated human respiratory syncytial virus infection. Mod Pathol. 2007;20(1):108–19.PubMedCrossRef
43.
Li SX, Lv TT, Zhang CP, Wang TQ, Tian D, Sun GY, Wang Y, Zhao XY, Duan WJ, Chen S, et al. Alteration of liver-infiltrated and peripheral blood double-negative T-cells in primary biliary cholangitis. Liver Int. 2019;39(9):1755–67.PubMedCrossRef
44.
Wu Z, Zheng Y, Sheng J, Han Y, Yang Y, Pan H, Yao J. CD3(+)CD4(-)CD8(-) (Double-Negative) T cells in inflammation, Immune disorders and Cancer. Front Immunol. 2022;13:816005.PubMedPubMedCentralCrossRef
45.
Lin HC, Liu YC, Hsing TY, Chen LL, Liu YC, Yen TY, Lu CY, Chang LY, Chen JM, Lee PI, et al. RSV pneumonia with or without bacterial co-infection among healthy children. J Formos Med Assoc. 2022;121(3):687–93.PubMedCrossRef
46.
47.
Ghazaly MMH, Abu Faddan NH, Raafat DM, Mohammed NA, Nadel S. Acute viral bronchiolitis as a cause of pediatric acute respiratory distress syndrome. Eur J Pediatr. 2021;180(4):1229–34.PubMedCrossRef
Metadata
Title
Respiratory syncytial virus subtypes in children with bronchiolitis: does it correlate with clinical severity?
Authors
Shuo Yang
Sukun Lu
Yakun Wang
Yinghui Guo
Zhuang Zhang
Weijian Wang
Le Wang
Publication date
01-12-2024
Publisher
BioMed Central
Published in
BMC Infectious Diseases / Issue 1/2024
Electronic ISSN: 1471-2334
DOI
https://doi.org/10.1186/s12879-024-09129-y

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