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01-10-2018 | Original Article

Respiratory motion reduction with a dual gating approach in myocardial perfusion SPECT: Effect on left ventricular functional parameters

Authors: Matti J. Kortelainen, MSc, Tuomas M. Koivumäki, PhD, Marko J. Vauhkonen, PhD, Marja K. Hedman, MD, PhD, Satu T. J. Kärkkäinen, MD, PhD, Juanita Niño Quintero, MD, Mikko A. Hakulinen, PhD

Published in: Journal of Nuclear Cardiology | Issue 5/2018

Abstract

Background

Respiratory motion (RM) complicates the analysis of myocardial perfusion (MP) single-photon emission computed tomography (SPECT) images. The effects of RM on left ventricular (LV) functional variables have not been thoroughly investigated.

Methods and results

Thoracic electrical bioimpedance and electrocardiographic signals were recorded from eighteen patients undergoing the rest phase of a 1-day stress/rest cardiac-gated MP-SPECT examination. The signals and list-mode emission data were retrospectively processed to yield standard cardiac- and dual-gated (respiratory and cardiac gating) image sets applying a novel algorithm. LV volume, MP, shape index (SI), wall motion (WM), wall thickening (WT), and phase analysis parameters were measured with Quantitative Perfusion SPECT/Quantitative Gated SPECT software (Cedars-Sinai Medical Center). Image quality was evaluated by three experienced physicians. Dual gating increased LV volume (77.1 ± 26.8 vs 79.8 ± 27.6 mL, P = .006) and decreased SI (0.57 ± 0.05 vs 0.56 ± 0.05, P = .036) and global WT (39.0 ± 11.8% vs 36.9 ± 9.4%, P = .034) compared to cardiac gating, but did not significantly alter perfusion, WM or phase analysis parameters or image quality (P > .05).

Conclusions

RM reduction has an effect on LV volume, shape, and WT parameters. RM exerts no significant effect on phase analysis parameters.

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Title: Respiratory motion reduction with a dual gating approach in myocardial perfusion SPECT: Effect on left ventricular functional parameters
Authors: Matti J. Kortelainen, MSc
Tuomas M. Koivumäki, PhD
Marko J. Vauhkonen, PhD
Marja K. Hedman, MD, PhD
Satu T. J. Kärkkäinen, MD, PhD
Juanita Niño Quintero, MD
Mikko A. Hakulinen, PhD
Publication date: 01-10-2018
Publisher: Springer US
Published in: Journal of Nuclear Cardiology / Issue 5/2018
Print ISSN: 1071-3581
Electronic ISSN: 1532-6551
DOI: https://doi.org/10.1007/s12350-017-0844-9

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Respiratory motion reduction with a dual gating approach in myocardial perfusion SPECT: Effect on left ventricular functional parameters

Abstract

Background

Methods and results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods and results

Conclusions

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