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Immunologic Research
Published in: Immunologic Research 4/2017

01-08-2017 | Review

Resolution of inflammation pathways in preeclampsia—a narrative review

Authors: Luiza Oliveira Perucci, Mário Dias Corrêa, Luci Maria Dusse, Karina Braga Gomes, Lirlândia Pires Sousa

Published in: Immunologic Research | Issue 4/2017

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Abstract

Preeclampsia (PE) is one of the leading causes of maternal morbidity and mortality worldwide. This disease is believed to occur in two stages with placental dysfunction in early pregnancy leading to maternal clinical findings after 20 weeks of gestation, as consequence of systemic inflammation, oxidative stress, and endothelial dysfunction. Much evidence suggests that PE women display an overshooting inflammatory response throughout pregnancy due to an unbalanced regulation of innate and adaptive immune responses. Recently, it has been suggested that dysregulation of endogenous protective pathways might be associated with PE etiopathogenesis. Resolution of inflammation is an active process coordinated by mediators from diverse nature that regulate key cellular events to restore tissue homeostasis. Inadequate or insufficient resolution of inflammation is believed to play an important role in the development of chronic inflammatory diseases, like PE. In this narrative review, we discuss possible pro-resolution pathways that might be compromised in PE women, which could be targets to novel therapeutic strategies in this disease.
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Metadata
Title
Resolution of inflammation pathways in preeclampsia—a narrative review
Authors
Luiza Oliveira Perucci
Mário Dias Corrêa
Luci Maria Dusse
Karina Braga Gomes
Lirlândia Pires Sousa
Publication date
01-08-2017
Publisher
Springer US
Published in
Immunologic Research / Issue 4/2017
Print ISSN: 0257-277X
Electronic ISSN: 1559-0755
DOI
https://doi.org/10.1007/s12026-017-8921-3

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