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Virology Journal
Published in: Virology Journal 1/2011

Open Access 01-12-2011 | Review

Research advances on flotillins

Authors: Feng Zhao, Jie Zhang, Yong-Sheng Liu, Li Li, Ya-Li He

Published in: Virology Journal | Issue 1/2011

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Abstract

The proteins of flotillin-1 and flotillin-2 were originally discovered in axon regeneration of goldfish retinal ganglion cells. They are generally used as marker proteins of lipid rafts and considered to be scaffolding proteins of lipid microdomains. Although they are ubiquitously expressed and well-conserved from fly to man, their exact functions remain controversial. In this review, we summarize the structure of flotillins and some functions of them, such as regulating axon regeneration, endocytosis, T cell activation, insulin signaling, membrane protein recruitment, roles in the progression of some diseases and so on.
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Metadata
Title
Research advances on flotillins
Authors
Feng Zhao
Jie Zhang
Yong-Sheng Liu
Li Li
Ya-Li He
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Virology Journal / Issue 1/2011
Electronic ISSN: 1743-422X
DOI
https://doi.org/10.1186/1743-422X-8-479

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