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Open Access 01-12-2018 | Research article

Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project

Authors: Trinidad Dierssen-Sotos, Camilo Palazuelos-Calderón, José-Juan Jiménez-Moleón, Nuria Aragonés, Jone M. Altzibar, Gemma Castaño-Vinyals, Vicente Martín-Sanchez, Inés Gómez-Acebo, Marcela Guevara, Adonina Tardón, Beatriz Pérez-Gómez, Pilar Amiano, Victor Moreno, Antonio J. Molina, Jéssica Alonso-Molero, Conchi Moreno-Iribas, Manolis Kogevinas, Marina Pollán, Javier Llorca

Published in: BMC Cancer | Issue 1/2018

Abstract

Background

Reproductive factors are well known risk factors for breast cancer; however, little is known about how genetic variants in hormonal pathways interact with that relationship.

Methods

One thousand one hundred thirty nine cases of breast cancer in women and 1322 frequency-matched controls were compared. Genetic variants in hormonal pathways (identified in the Kyoto Encyclopedia of Genes and Genomes) were screened according to their relationship with breast cancer using the Cochran-Armitage statistic. Information on reproductive factors was obtained using a face-to-face questionnaire. The interaction among the selected genetic variants and reproductive factors was tested with logistic regression.

Results

Concerning C allele in rs2229712, compared to nulliparity in non-carriers the ORs for 1–2 and > 2 deliveries were 0.48 (0.28–0.81) and 0.34 (0.19–0.59), and in C carriers they were 0.92 (0.42–1.98) and 0.71 (0.31–1.61). Similar results were found in women carrying the C allele in rs1269851. Carriers of Allele T in rs35652107 and allele C in rs6018027 had the delivery number effect more pronounced.

Conclusions

The number of deliveries had a dose-response protective effect on breast cancer; women carrying C allele in rs2229712 did not benefit from this protective effect.

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Title: Reproductive risk factors in breast cancer and genetic hormonal pathways: a gene-environment interaction in the MCC-Spain project
Authors: Trinidad Dierssen-Sotos
Camilo Palazuelos-Calderón
José-Juan Jiménez-Moleón
Nuria Aragonés
Jone M. Altzibar
Gemma Castaño-Vinyals
Vicente Martín-Sanchez
Inés Gómez-Acebo
Marcela Guevara
Adonina Tardón
Beatriz Pérez-Gómez
Pilar Amiano
Victor Moreno
Antonio J. Molina
Jéssica Alonso-Molero
Conchi Moreno-Iribas
Manolis Kogevinas
Marina Pollán
Javier Llorca
Publication date: 01-12-2018
Publisher: BioMed Central
Published in: BMC Cancer / Issue 1/2018
Electronic ISSN: 1471-2407
DOI: https://doi.org/10.1186/s12885-018-4182-3

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