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Graefe's Archive for Clinical and Experimental Ophthalmology

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01-03-2011 | Letter to the Editor

Reply to: IL-2 and IFN-gamma and diabetic retinopathy

Authors: Siv Johnsen-Soriano, María Sancho-Tello, Emma Arnal, Amparo Navea, Enrique Cervera, Francisco Bosch-Morell, Maria Miranda, Francisco Javier Romero

Published in: Graefe's Archive for Clinical and Experimental Ophthalmology | Issue 3/2011

Excerpt

It is well-known that retinal changes in diabetes are thought to be initiated by sustained hyperglycemia and fluctuation of blood glucose, as suggested by Dr Viroj Wiwanitkit, leading to biochemical abnormalities, that include all alterations of various vasoactive and growth factors [1], nonenzymatic glycation [2, 3], increase in the polyol pathway and redox imbalance [1, 4‐9], and activation of protein kinase C (PKC) [10, 11]. …

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Kern TS, Engerman RL (2001) Pharmacological inhibition of diabetic retinopathy: aminoguanidine and aspirin. Diabetes 50:1636–1642PubMedCrossRef

Engerman RL, Kern TS, Garment MB (1993) Capillary basement membrane in retina, kidney, and muscle of diabetic dogs and galactosemic dogs and its response to 5 years aldose reductase inhibition. J Diabetes Complications 7:241–245PubMedCrossRef

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Arnal E, Miranda M, Johnsen-Soriano S, Alvarez-Nölting R, Díaz-Llopis M, Araiz J, Cervera E, Bosch-Morell F, Romero FJ (2009) Beneficial effect of docosahexaenoic acid and lutein on retinal structural, metabolic and functional abnormalities in diabetic rats. Curr Eye Res 34:928–938PubMedCrossRef

Johnsen-Soriano S, Garcia-Pous M, Arnal E, Sancho-Tello M, Garcia-Delpech S, Miranda M, Bosch-Morell F, Diaz-Llopis M, Navea A, Romero FJ (2008) Early lipoic acid intake protects retina of diabetic mice. Free Radic Res 42:613–617PubMedCrossRef

Miranda M, Muriach M, Roma J, Bosch-Morell F, Genovés JM, Barcia J, Araiz J, Díaz-Llospis M, Romero FJ (2006) Oxidative stress in a model of experimental diabetic retinopathy: the utility of peroxinytrite scavengers. Arch Soc Esp Oftalmol 81:27–32PubMedCrossRef

Miranda M, Muriach M, Johnsen S, Bosch-Morell F, Araiz J, Romá J, Romero FJ (2004) Oxidative stress in a model for experimental diabetic retinopathy: treatment with antioxidants. Arch Soc Esp Oftalmol 79:289–294PubMedCrossRef

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Koya D, King GL (1998) Protein kinase C activation and the development of diabetic complications. Diabetes 47:859–866PubMedCrossRef

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Okumura K, Nishiura T, Awaji Y, Kondo J, Hashimoto H, Ito T (1991) 1, 2-diacylglycerol content and its composition in thoracic aorta of diabetic rats. Diabetes 40:820–824PubMedCrossRef

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Bonnefont-Rousselot D (2002) Glucose and reactive oxygen species. Curr Opin Clin Nutr Meta Care 5:561–568CrossRef

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Cotran RS, Kumar V, Collins T (1999) Robbins pathologic basis of disease. Saunders, Philadelphia

Title: Reply to: IL-2 and IFN-gamma and diabetic retinopathy
Authors: Siv Johnsen-Soriano
María Sancho-Tello
Emma Arnal
Amparo Navea
Enrique Cervera
Francisco Bosch-Morell
Maria Miranda
Francisco Javier Romero
Publication date: 01-03-2011
Publisher: Springer-Verlag
Published in: Graefe's Archive for Clinical and Experimental Ophthalmology / Issue 3/2011
Print ISSN: 0721-832X
Electronic ISSN: 1435-702X
DOI: https://doi.org/10.1007/s00417-010-1450-6

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