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Critical Care
Published in: Critical Care 2/2012

Open Access 01-04-2012 | Meeting abstract

Reperfusion injury in acute myocardial infarction

Authors: Gregor Simonis, Ruth H Strasser, Bernd Ebner

Published in: Critical Care | Special Issue 2/2012

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Excerpt

For many years it has been shown that the size of a myocardial infarction is not only determined by ischemic damage, but also by reperfusion itself. This reperfusion injury contributes to up to 50% of the final infarct size. Mechanical postconditioning using short periods of ischemia immediately after reperfusion, pharmacologic postconditioning targeted to prevent opening of the mitochondrial permeability transition pore, and hypothermia have been shown to prevent reperfusion injury in animals and to reduce infarct size in smaller studies. Larger studies targeted to reduce heart failure and mortality are eagerly awaited. …
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Metadata
Title
Reperfusion injury in acute myocardial infarction
Authors
Gregor Simonis
Ruth H Strasser
Bernd Ebner
Publication date
01-04-2012
Publisher
BioMed Central
Published in
Critical Care / Issue Special Issue 2/2012
Electronic ISSN: 1364-8535
DOI
https://doi.org/10.1186/cc11280

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