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01-10-2011 | Original Article

Repeat treatment for recurrent hepatocellular carcinoma: is it validated?

Authors: Yoji Kishi, Akio Saiura, Junji Yamamoto, Rintaro Koga, Makoto Seki, Ryo Morimura, Ryuji Yoshioka, Norihiro Kokudo, Toshiharu Yamaguchi

Published in: Langenbeck's Archives of Surgery | Issue 7/2011

Abstract

Purpose

Hepatocellular carcinoma (HCC) usually recurs repeatedly and locoregional treatment is attempted unless liver function has deteriorated. This study was aimed to evaluate the effect of repeated treatment on patient prognosis.

Methods

The HCC recurrence pattern and types of treatment for recurrence after hepatic resection were reviewed in 134 patients. The effects of repeated treatment on prognosis were evaluated. Univariate and multivariate analyses were performed to determine the prognostic predictors after initial recurrence.

Results

Median number of treatments after recurrence was 3 (range, 0–12). Transarterial chemoembolization was the most common treatment. The number of treatments, but not the type of treatment, was associated with the prognosis. Multivariate analysis showed that a >20% indocyanine green retention rate at 15 min (hazard ratio [HR] = 2.65; 95% confidential interval [CI], 1.53–5.62), size of primary tumor >5 cm (HR = 1.81; 95% CI, 1.05–3.08), recurrence-free interval <1 year (HR = 2.17; 95% CI, 1.28–3.81), size of recurrent tumor >3 cm (HR = 2.61; 95% CI, 1.03–5.77–0.95), and extrahepatic recurrence (HR = 6.35; 95% CI, 3.49–11.39) were independent predictors of poor survival.

Conclusion

The prognosis after recurrence is poor in cases with large tumors or poor liver function. Repeated locoregional treatment contributes to prolong patient prognosis, especially in cases with a small tumor size, long recurrence-free interval, and no extrahepatic metastases.

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Title: Repeat treatment for recurrent hepatocellular carcinoma: is it validated?
Authors: Yoji Kishi
Akio Saiura
Junji Yamamoto
Rintaro Koga
Makoto Seki
Ryo Morimura
Ryuji Yoshioka
Norihiro Kokudo
Toshiharu Yamaguchi
Publication date: 01-10-2011
Publisher: Springer-Verlag
Published in: Langenbeck's Archives of Surgery / Issue 7/2011
Print ISSN: 1435-2443
Electronic ISSN: 1435-2451
DOI: https://doi.org/10.1007/s00423-011-0837-0

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Repeat treatment for recurrent hepatocellular carcinoma: is it validated?

Abstract

Purpose

Methods

Results

Conclusion

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusion

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