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Published in: Urolithiasis 6/2003

01-12-2003 | Original Paper

Renal phosphate leak in patients with idiopathic hypercalciuria and calcium nephrolithiasis

Authors: Armando Luis Negri, Rodolfo Spivacow, Elisa Del Valle, Erich Fradinger, Alicia Marino, Jose Ruben Zanchetta

Published in: Urolithiasis | Issue 6/2003

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Abstract

Although urine phosphate loss has been associated with hypercalciuria, it is debated how frequently renal phosphate leak is present in hypercalciuric patients. We reviewed the records of 100 consecutive adult patients who were diagnosed with idiopathic hypercalciuria and calcium urolithiasis, searching for the presence of renal phosphate leak. The renal phosphate threshold, normalized for the glomerular filtration rate (TmPO4/GFR), of the hypercalciuric patients followed a normal distribution and had a good correlation with serum phosphate (r=0.77; p<0.0001). There were no correlations between TmPO4/GFR and urinary calcium or between serum phosphorus and urinary calcium. We found only nine patients (9%) with renal phosphate leak. These patients had a mean TmPO4/GFR of 2.19 mg% (0.70 mmol/l) and serum phosphorus of 2.65 mg% (0.85 mmol/l). Nevertheless, urinary calcium was not significantly different between patients with or without low TmPO4/GFR. We conclude that renal phosphate leak is an infrequent finding in patients with idiopathic hypercalciuria and is not associated with a higher urinary calcium loss.
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Metadata
Title
Renal phosphate leak in patients with idiopathic hypercalciuria and calcium nephrolithiasis
Authors
Armando Luis Negri
Rodolfo Spivacow
Elisa Del Valle
Erich Fradinger
Alicia Marino
Jose Ruben Zanchetta
Publication date
01-12-2003
Publisher
Springer-Verlag
Published in
Urolithiasis / Issue 6/2003
Print ISSN: 2194-7228
Electronic ISSN: 2194-7236
DOI
https://doi.org/10.1007/s00240-003-0353-y

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