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Published in: Indian Journal of Hematology and Blood Transfusion 1/2014

01-09-2014 | Case Report

Remission of Microangiopathy in Transplanted Thalassemic Child

Authors: Priya Marwah, Rajpreet Soni, Lawrence Faulkner, Mohammed El Missiry, Cornelio Uderzo

Published in: Indian Journal of Hematology and Blood Transfusion | Special Issue 1/2014

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Abstract

Transplant associated thrombotic microangiopathy is a severe complication of Hematopoeitic stem cell transplantation. Although there is agreement in terms of diagnostic criteria, treatment options are not clarified yet. We present a patient aged 2.6 years who developed transplant associated thrombotic microangiopathy after allogeneic bone marrow transplantation and to discuss both risk factors and possible spontaneous remission of transplant associated thrombotic microangiopathy.
Literature
1.
go back to reference Ho VT, Cutler C, Carter S et al (2005) Blood and marrow transplant clinical trials network toxicity committee consensus summary: thrombotic microangiopathy after hematopoetic stem cell transplantation. Biol Blood Marrow Transpl 11:571–575CrossRef Ho VT, Cutler C, Carter S et al (2005) Blood and marrow transplant clinical trials network toxicity committee consensus summary: thrombotic microangiopathy after hematopoetic stem cell transplantation. Biol Blood Marrow Transpl 11:571–575CrossRef
2.
go back to reference Uderzo C, Bonanomi S et al (2006) Risk factors and severe outcome in Thrombotic Microangiopathy after allogeneic hematopoetic stem cell transplantation. Transplantation 82:638PubMedCrossRef Uderzo C, Bonanomi S et al (2006) Risk factors and severe outcome in Thrombotic Microangiopathy after allogeneic hematopoetic stem cell transplantation. Transplantation 82:638PubMedCrossRef
3.
go back to reference Cutler C, Henry NL, Magee C et al (2005) Sirolimus and thrombotic microangiopathy after allogeneic hematopoetic stem cell transplantation. Biol Blood Marrow Transpl 11:551–557CrossRef Cutler C, Henry NL, Magee C et al (2005) Sirolimus and thrombotic microangiopathy after allogeneic hematopoetic stem cell transplantation. Biol Blood Marrow Transpl 11:551–557CrossRef
5.
go back to reference Shimoni et al (2004) Thrombotic microangiopathy after allogeneic stem cell transplantation in the era of reduced intensity conditioning. The incidence is not reduced. Biol Blood Marrow Transpl 10:484CrossRef Shimoni et al (2004) Thrombotic microangiopathy after allogeneic stem cell transplantation in the era of reduced intensity conditioning. The incidence is not reduced. Biol Blood Marrow Transpl 10:484CrossRef
6.
go back to reference Busca A, Uderzo C (2000) Bone marrow transplant associated thrombotic microangiopathy. Hematology 5:53PubMed Busca A, Uderzo C (2000) Bone marrow transplant associated thrombotic microangiopathy. Hematology 5:53PubMed
7.
go back to reference Grigg a et al (1995) Disseminated fungal infection and early onset microangiopathy after allogeneic bone marrow transplantation. Bone Marrow Transpl 15:795 Grigg a et al (1995) Disseminated fungal infection and early onset microangiopathy after allogeneic bone marrow transplantation. Bone Marrow Transpl 15:795
8.
go back to reference Uderzo C, Fumagilli M et al (2000) Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing BMT. Bone Marrow Transpl 26:1005CrossRef Uderzo C, Fumagilli M et al (2000) Impact of thrombotic thrombocytopenic purpura on leukemic children undergoing BMT. Bone Marrow Transpl 26:1005CrossRef
9.
go back to reference Cho BS, Yahng SA, Lee SE et al (2010) Validation of recently proposed consensus criteria for thrombotic microangiopathy after allogeneic hematopoetic stem cell transplantation. Transplantation 90(8):918–926PubMedCrossRef Cho BS, Yahng SA, Lee SE et al (2010) Validation of recently proposed consensus criteria for thrombotic microangiopathy after allogeneic hematopoetic stem cell transplantation. Transplantation 90(8):918–926PubMedCrossRef
10.
go back to reference Moore JC, Arnold DM, Leber BF et al (2007) Intravenous immunoglobulins as an adjunct to plasma exchange for the treatment of chronic thrombotic thrombocytopenic purpura. Vox Sang 93:173–175PubMedCrossRef Moore JC, Arnold DM, Leber BF et al (2007) Intravenous immunoglobulins as an adjunct to plasma exchange for the treatment of chronic thrombotic thrombocytopenic purpura. Vox Sang 93:173–175PubMedCrossRef
11.
go back to reference Wolff d, Wilhelm s, Hahn J et al (2006) Replacement of calcineurin inhibitors with daclizumab in patients with transplant associated microangiopathy or renal insufficiency associated with GVHD. Bone Marrow Transpl 38:445–451CrossRef Wolff d, Wilhelm s, Hahn J et al (2006) Replacement of calcineurin inhibitors with daclizumab in patients with transplant associated microangiopathy or renal insufficiency associated with GVHD. Bone Marrow Transpl 38:445–451CrossRef
12.
go back to reference Wy Au, Ma ES, Lee TL et al (2007) Successful treatment of thrombotic microangiopathy after hematopoetic stem cell transplantation with rituximab. Br J Hematol 137:475–478CrossRef Wy Au, Ma ES, Lee TL et al (2007) Successful treatment of thrombotic microangiopathy after hematopoetic stem cell transplantation with rituximab. Br J Hematol 137:475–478CrossRef
13.
go back to reference Ho VT, Linden E, Revia c et al (2007) Hepatic veno occlusive disease after hematopoetic stem cell transplantation: review and update on the use of Defibrotide. Semin Thromb Hemost 33:373–388PubMedCrossRef Ho VT, Linden E, Revia c et al (2007) Hepatic veno occlusive disease after hematopoetic stem cell transplantation: review and update on the use of Defibrotide. Semin Thromb Hemost 33:373–388PubMedCrossRef
14.
go back to reference Bullery SR, Strahm B, Doyle J et al (2007) Defibrotide for the treatment of VOD in children. Pediatr Blood and cancer 48:700–704CrossRef Bullery SR, Strahm B, Doyle J et al (2007) Defibrotide for the treatment of VOD in children. Pediatr Blood and cancer 48:700–704CrossRef
15.
go back to reference Corti p, Uderzo c et al (2002) Defibrotide as promising treatment of thrombotic thrombocytopenic purpura in patients undergoing bone marrow transplantation. Bone Marrow Transpl 29:542CrossRef Corti p, Uderzo c et al (2002) Defibrotide as promising treatment of thrombotic thrombocytopenic purpura in patients undergoing bone marrow transplantation. Bone Marrow Transpl 29:542CrossRef
16.
go back to reference Ulutin ON (1993) Anti thrombotic effect and clinical potential of DFT. Semin Thromb Hemost 19:186PubMed Ulutin ON (1993) Anti thrombotic effect and clinical potential of DFT. Semin Thromb Hemost 19:186PubMed
17.
go back to reference Laski bl, Goebel J, Davis S, Jodele S (2011) Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation- associated thrombotic microangiopathy. Blood 118(6):1452–1462CrossRef Laski bl, Goebel J, Davis S, Jodele S (2011) Small vessels, big trouble in the kidneys and beyond: hematopoietic stem cell transplantation- associated thrombotic microangiopathy. Blood 118(6):1452–1462CrossRef
Metadata
Title
Remission of Microangiopathy in Transplanted Thalassemic Child
Authors
Priya Marwah
Rajpreet Soni
Lawrence Faulkner
Mohammed El Missiry
Cornelio Uderzo
Publication date
01-09-2014
Publisher
Springer India
Published in
Indian Journal of Hematology and Blood Transfusion / Issue Special Issue 1/2014
Print ISSN: 0971-4502
Electronic ISSN: 0974-0449
DOI
https://doi.org/10.1007/s12288-014-0404-2

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