Top

Published in:

01-10-2007 | Brief Report

Remission of membranoproliferative glomerulonephritis type I with the use of tacrolimus

Authors: Maha Haddad, Keith Lau, Lavjay Butani

Published in: Pediatric Nephrology | Issue 10/2007

Abstract

Membranoproliferative glomerulonephritis, albeit uncommon, is associated with considerable morbidity and mortality in children. Corticosteroids are the mainstay of therapy for severe disease, although data supporting their use are limited. We report our experience in treating two children with nephrotic–nephritic syndrome from idiopathic membranoproliferative glomerulonephritis. Both children experienced a suboptimal response to prolonged courses of steroids and were started on tacrolimus as a steroid-sparing agent. Rapid and complete remission was achieved in both children after initiation of tacrolimus. The purpose of our report is to increase awareness of health care professionals to the potential benefits of this agent in inducing remission in children with severe membranoproliferative glomerulonephritis.

Barbiano di Belgiojoso G, Baroni M, Pagliari B, Lavagni MG, Porri MT, Banfi G, Colasanti G, Confalonieri R (1985) Is membranoproliferative glomerulonephritis really decreasing? A multicentre study of 1,548 cases of primary glomerulonephritis. Nephron 40:380–381CrossRef

Arslan S, Saatci U, Ozen S, Bakkaloglu A, Besbas N, Tinaztepe K, Hayran M (1997) Membranoproliferative glomerulonephritis in childhood: factors affecting prognosis. Int Urol Nephrol 29:711–716CrossRef

Habib R, Kleinknecht C, Gubler MC, Levy M (1973) Idiopathic membranoproliferative glomerulonephritis in children. Report of 105 cases. Clin Nephrol 1:194–214PubMed

Karakayali FY, Ozdemir H, Kivrakdal S, Colak T, Emiroglu R, Haberal M (2006) Recurrent glomerular diseases after renal transplantation. Transplant Proc 38:470–472CrossRef

D’Amico G, Ferrario F (1992) Mesangiocapillary glomerulonephritis. J Am Soc Nephrol 2:S159–S166PubMed

Tarshish P, Bernstein J, Tobin JN, Edelmann CM Jr (1992) Treatment of mesangiocapillary glomerulonephritis with alternate-day prednisone—a report of the International Study of Kidney Disease in Children. Pediatr Nephrol 6:123–130CrossRef

Levin A (1999) Management of membranoproliferative glomerulonephritis: evidence-based recommendations. Kidney Int (Suppl)70:S41–S46CrossRef

Bergstein JM, Andreoli SP (1995) Response of type I membranoproliferative glomerulonephritis to pulse methylprednisolone and alternate-day prednisone therapy. Pediatr Nephrol 9:268–271CrossRef

Jones G, Juszczak M, Kingdon E, Harber M, Sweny P, Burns A (2004) Treatment of idiopathic membranoproliferative glomerulonephritis with mycophenolate mofetil and steroids. Nephrol Dial Transplant 19:3160–3164CrossRef

10.

Xia Z, Liu G, Gao Y, Fan Z, Fu Y, Zhang LF, Ren X, Gao C (2006) FK506 in the treatment of children with nephrotic syndrome of different pathological types. Clin Nephrol 66:85–88CrossRef

11.

Cansick JC, Lennon R, Cummins CL, Howie AJ, McGraw ME, Saleem MA, Tizard EJ, Hulton SA, Milford DV, Taylor CM (2004) Prognosis, treatment and outcome of childhood mesangiocapillary (membranoproliferative) glomerulonephritis. Nephrol Dial Transplant 19:2769–2777CrossRef

12.

Butani L, Radsliff E, Makker S (2003) Tacrolimus induces remission in children with steroid-resistant nephrotic syndrome. J Am Soc Nephrol 14:39A

13.

Kiyomasu T, Shibata M, Kurosu H, Shiraishi K, Hashimoto H, Hayashidera T, Akiyama Y, Takeda N (2002) Cyclosporin A treatment for membranoproliferative glomerulonephritis type II. Nephron 91:509–511CrossRef

14.

Ahsan N, Manning EC, Dabbs DJ, Gifford RR, Yang HC (1997) Recurrent type I membranoproliferative glomerulonephritis after renal transplantation and protective role of cyclosporine in acute crescentic transformation. Clin Transplant 11:9–14PubMed

15.

Cahen R, Trolliet P, Dijoud F, Megri K, Francois B (1995) Severe recurrence of type I membranoproliferative glomerulonephritis after transplantation: remission on steroids and cyclophosphamide. Transplant Proc 27:1746–1747PubMed

16.

Iyengar A, Karthik S, Kumar A, Biswas S, Phadke K (2006) Cyclosporine in steroid dependent and resistant childhood nephrotic syndrome. Indian Pediatr 43:14–19

17.

Singh A, Tejani C, Tejani A (1999) One-center experience with cyclosporine in refractory nephrotic syndrome in children. Pediatr Nephrol 13:26–32CrossRef

18.

Trompeter R, Filler G, Webb NJ, Watson AR, Milford DV, Tyden G, Grenda R, Janda J, Hughes D, Ehrich JH, Klare B, Zacchello G, Bjorn Brekke I, McGraw M, Perner F, Ghio L, Balzar E, Friman S, Gusmano R, Stolpe J (2002) Randomized trial of tacrolimus versus cyclosporin microemulsion in renal transplantation. Pediatr Nephrol 17:141–149CrossRef

19.

Filler G, Grygas R, Mai I, Stolpe HJ, Greiner C, Bauer S, Ehrich JH (1997) Pharmacokinetics of tacrolimus (FK 506) in children and adolescents with renal transplants. Nephrol Dial Transplant 12:1668–1671CrossRef

Title: Remission of membranoproliferative glomerulonephritis type I with the use of tacrolimus
Authors: Maha Haddad
Keith Lau
Lavjay Butani
Publication date: 01-10-2007
Publisher: Springer Berlin Heidelberg
Published in: Pediatric Nephrology / Issue 10/2007
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI: https://doi.org/10.1007/s00467-007-0523-1

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Remission of membranoproliferative glomerulonephritis type I with the use of tacrolimus

Abstract

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Please log in to get access to this content

Other articles of this Issue 10/2007

Improving outcomes from acute kidney injury: report of an initiative

An Acadian variant of Fanconi syndrome

In memory of John E. Lewy

A case of homozygous familial hypercholesterolemia with focal segmental glomerulosclerosis

Pulmonary inflammatory myofibroblastic tumor associated with nephrotic syndrome

Blood pressure in the first year of life in healthy infants born at term