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01-06-2015 | Original Article

Remaining symptoms in half the children treated for milk allergy

Authors: Nicole C. M. Petrus, Anne-Fleur A. Schoemaker, Meike W. van Hoek, Laura Jansen, Marijke C. Jansen-van der Weide, Wim M. C. van Aalderen, Aline B. Sprikkelman

Published in: European Journal of Pediatrics | Issue 6/2015

Abstract

The aim of this study was to investigate the cumulative incidence and predictive variables of treatment failure with a whey-based extensively hydrolyzed formula (w-eHF) in children with cow’s milk allergy (CMA). All children were diagnosed with CMA, using double-blind placebo-controlled food challenge (DBPCFC) with amino acid-based formula as placebo, and receive w-eHF treatment after diagnosis. Forty-nine children with CMA were included. w-eHF treatment failure was defined as incomplete resolution of original CMA symptoms upon w-eHF treatment and disappearance of these symptoms upon replacement of w-eHF with amino acid-based formula. A multiple logistic regression model was used to investigate which variables could predict treatment failure. Twenty-five (51 %; 95 % confidence interval (CI) 38–64 %) of the children with CMA failed on w-eHF. Only “gastrointestinal discomfort” was found to contribute independently to the probability of failing w-eHF, odds ratio (95 % CI) 8.994 (1.007–79.457).

Conclusions: In half of the children with proven CMA, there is incomplete resolution of symptoms upon w-eHF treatment. This study needs to be repeated including DBPCFC with w-eHF to provide more definitive diagnosis, especially since gastrointestinal discomfort seems to be the sole predictive variable for treatment failure. In the meantime, a change in formula should be considered in children with incomplete symptom resolution upon w-eHF treatment.

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Title: Remaining symptoms in half the children treated for milk allergy
Authors: Nicole C. M. Petrus
Anne-Fleur A. Schoemaker
Meike W. van Hoek
Laura Jansen
Marijke C. Jansen-van der Weide
Wim M. C. van Aalderen
Aline B. Sprikkelman
Publication date: 01-06-2015
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Pediatrics / Issue 6/2015
Print ISSN: 0340-6199
Electronic ISSN: 1432-1076
DOI: https://doi.org/10.1007/s00431-014-2456-6

At a glance: The STEP trials

Springer Medicine

Remaining symptoms in half the children treated for milk allergy

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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