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Nutrition Journal
Published in: Nutrition Journal 1/2011

Open Access 01-12-2011 | Short Report

Relationship of Adiposity and Insulin Resistance Mediated by Inflammation in a Group of Overweight and Obese Chilean Adolescents

Authors: Marcela Reyes, Sheila Gahagan, Erik Díaz, Estela Blanco, Laura Leiva, Lydia Lera, Raquel Burrows

Published in: Nutrition Journal | Issue 1/2011

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Abstract

The mild chronic inflammatory state associated with obesity may be an important link between adiposity and insulin resistance (IR). In a sample of 137 overweight and obese Chilean adolescents, we assessed associations between high-sensitivity C-reactive protein (hs-CRP), IR and adiposity; explored sex differences; and evaluated whether hs-CRP mediated the relationship between adiposity and IR. Positive relationships between hs-CRP, IR and 2 measures of adiposity were found. Hs-CRP was associated with waist circumference (WC) in boys and fat mass index (FMI) in girls. Using path analysis, we found that hs-CRP mediated the relationship between adiposity (WC and FMI) and the homeostatic model assessment of insulin resistance (HOMA-IR) (p < 0.05) in both sexes. Our novel finding is that inflammation statistically mediated the well described link between increased adiposity and IR.
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Metadata
Title
Relationship of Adiposity and Insulin Resistance Mediated by Inflammation in a Group of Overweight and Obese Chilean Adolescents
Authors
Marcela Reyes
Sheila Gahagan
Erik Díaz
Estela Blanco
Laura Leiva
Lydia Lera
Raquel Burrows
Publication date
01-12-2011
Publisher
BioMed Central
Published in
Nutrition Journal / Issue 1/2011
Electronic ISSN: 1475-2891
DOI
https://doi.org/10.1186/1475-2891-10-4

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