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01-08-2018 | Original Article

Relationship between sleep and exercise as colorectal cancer survivors transition off treatment

Authors: Theresa Coles, Antonia V. Bennett, Xianming Tan, Claudio L. Battaglini, Hanna K. Sanoff, Ethan Basch, Roxanne E. Jensen, Bryce B. Reeve

Published in: Supportive Care in Cancer | Issue 8/2018

Abstract

Purpose

The primary objective of this study was to evaluate the relationship between exercise and sleep disturbance in a sample of individuals diagnosed with stage I, II, and III colorectal cancer (CRC) as patients transitioned off first-line treatment. We also sought to identify heterogeneity in the relationship between sleep disturbance and exercise.

Methods

Data were obtained from the MY-Health study, a community-based observational study of adults diagnosed with cancer. Patient-Reported Outcomes Measurement Information System® (PROMIS) measures (e.g., PROMIS Sleep) were administered, and participants self-reported demographics, comorbidities, cancer treatment, and exercise. Regression mixture and multiple regression models were used to evaluate the relationship between sleep disturbance and exercise cross-sectionally at an average of 10 months after diagnosis, and the change in sleep disturbance over a 7-month period, from approximately 10 to 17 months post-diagnosis.

Results

Patients whose exercise was categorized as likely at or above American College of Sports Medicine’s guidelines did not report statistically better sleep quality compared to patients who were classified as not active. However, retirement (B = − 2.4), anxiety (B = 0.21), and fatigue (B = 0.24) had statistically significant relationships with sleep disturbance (p < 0.05). Increase in exercise was not significantly associated with a decrease in sleep disturbance. No statistical heterogeneity was revealed in the relationship between sleep and exercise.

Conclusions

Further prospective research using an objective measure of exercise is warranted to confirm or refute the nature of the relationship between exercise and sleep disturbance in individuals diagnosed with CRC transitioning off first-line treatment.

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Title: Relationship between sleep and exercise as colorectal cancer survivors transition off treatment
Authors: Theresa Coles
Antonia V. Bennett
Xianming Tan
Claudio L. Battaglini
Hanna K. Sanoff
Ethan Basch
Roxanne E. Jensen
Bryce B. Reeve
Publication date: 01-08-2018
Publisher: Springer Berlin Heidelberg
Published in: Supportive Care in Cancer / Issue 8/2018
Print ISSN: 0941-4355
Electronic ISSN: 1433-7339
DOI: https://doi.org/10.1007/s00520-018-4110-8

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