Top

Critical Care

Published in:

Open Access 01-04-2013 | Research

Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review

Authors: Christophe Lelubre, Jean-Louis Vincent

Published in: Critical Care | Issue 2/2013

Abstract

Introduction

The duration of red blood cell (RBC) storage before transfusion may alter RBC function and supernatant and, therefore, influence the incidence of complications or even mortality.

Methods

A MEDLINE search from 1983 to December 2012 was performed to identify studies reporting age of transfused RBCs and mortality or morbidity in adult patients.

Results

Fifty-five studies were identified; most were single-center (93%) and retrospective (64%), with only a few, small randomized studies (eight studies, 14.5%). The numbers of subjects included ranged from eight to 364,037. Morbidity outcomes included hospital and intensive care unit (ICU) length of stay (LOS), infections, multiple organ failure, microcirculatory alterations, cancer recurrence, thrombosis, bleeding, vasospasm after subarachnoid hemorrhage, and cognitive dysfunction. Overall, half of the studies showed no deleterious effects of aged compared to fresh blood on any endpoint. Eleven of twenty-two (50%) studies reported no increased mortality, three of nine (33%) showed no increased LOS with older RBCs and eight of twelve (66%) studies showed no increased risks of organ failure. Ten of eighteen (55%) studies showed increased infections with transfusion of older RBCs. The considerable heterogeneity among studies and numerous methodological flaws precluded a formal meta-analysis.

Conclusions

In this systematic review, we could find no definitive argument to support the superiority of fresh over older RBCs for transfusion.

Available only for authorised users

Hess JR: Red cell changes during storage. Transfus Apher Sci 2010, 43: 51-59. 10.1016/j.transci.2010.05.009PubMed

Klein HG, Spahn DR, Carson JL: Red blood cell transfusion in clinical practice. Lancet 2007, 370: 415-426. 10.1016/S0140-6736(07)61197-0PubMed

Marik PE, Corwin HL: Efficacy of red blood cell transfusion in the critically ill: a systematic review of the literature. Crit Care Med 2008, 36: 2667-2674. 10.1097/CCM.0b013e3181844677PubMed

Chin-Yee I, Arya N, d'Almeida MS: The red cell storage lesion and its implication for transfusion. Transfus Sci 1997, 18: 447-458. 10.1016/S0955-3886(97)00043-XPubMed

Hamasaki N, Yamamoto M: Red blood cell function and blood storage. Vox Sang 2000, 79: 191-197. 10.1046/j.1423-0410.2000.7940191.xPubMed

Korgun DK, Bilmen S, Yesilkaya A: Alterations in the erythrocyte antioxidant system of blood stored in blood bags. Res Commun Mol Pathol Pharmacol 2001, 109: 357-363.PubMed

Bosman GJ, Lasonder E, Luten M, Roerdinkholder-Stoelwinder B, Novotny VM, Bos H, De Grip WJ: The proteome of red cell membranes and vesicles during storage in blood bank conditions. Transfusion 2008, 48: 827-835.PubMed

Sweeney J, Kouttab N, Kurtis J: Stored red blood cell supernatant facilitates thrombin generation. Transfusion 2009, 49: 1569-1579. 10.1111/j.1537-2995.2009.02196.xPubMed

Chin-Yee IH, Gray-Statchuk L, Milkovich S, Ellis CG: Transfusion of stored red blood cells adhere in the rat microvasculature. Transfusion 2009, 49: 2304-2310. 10.1111/j.1537-2995.2009.02315.xPubMed

10.

Bosman GJ, Lasonder E, Groenen-Dopp YA, Willekens FL, Werre JM, Novotny VM: Comparative proteomics of erythrocyte aging in vivo and in vitro. J Proteomics 2010, 73: 396-402. 10.1016/j.jprot.2009.07.010PubMed

11.

Donadee C, Raat NJ, Kanias T, Tejero J, Lee JS, Kelley EE, Zhao X, Liu C, Reynolds H, Azarov I, Frizzell S, Meyer EM, Donnenberg AD, Qu L, Triulzi D, Kim-Shapiro DB, Gladwin MT: Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion. Circulation 2011, 124: 465-476. 10.1161/CIRCULATIONAHA.110.008698PubMedCentralPubMed

12.

Hod EA, Spitalnik SL: Harmful effects of transfusion of older stored red blood cells: iron and inflammation. Transfusion 2011, 51: 881-885. 10.1111/j.1537-2995.2011.03096.xPubMed

13.

Hod EA, Brittenham GM, Billote GB, Francis RO, Ginzburg YZ, Hendrickson JE, Jhang J, Schwartz J, Sharma S, Sheth S, Sireci AN, Stephens HL, Stotler BA, Wojczyk BS, Zimring JC, Spitalnik SL: Transfusion of human volunteers with older, stored red blood cells produces extravascular hemolysis and circulating non-transferrin-bound iron. Blood 2011, 118: 6675-6682. 10.1182/blood-2011-08-371849PubMedCentralPubMed

14.

Silliman CC, Voelkel NF, Allard JD, Elzi DJ, Tuder RM, Johnson JL, Ambruso DR: Plasma and lipids from stored packed red blood cells cause acute lung injury in an animal model. J Clin Invest 1998, 101: 1458-1467. 10.1172/JCI1841PubMedCentralPubMed

15.

Raat NJ, Verhoeven AJ, Mik EG, Gouwerok CW, Verhaar R, Goedhart PT, de Korte D, Ince C: The effect of storage time of human red cells on intestinal microcirculatory oxygenation in a rat isovolemic exchange model. Crit Care Med 2005, 33: 39-45. 10.1097/01.CCM.0000150655.75519.02PubMed

16.

van Bommel J, de Korte D, Lind A, Siegemund M, Trouwborst A, Verhoeven AJ, Ince C, Henny CP: The effect of the transfusion of stored RBCs on intestinal microvascular oxygenation in the rat. Transfusion 2001, 41: 1515-1523. 10.1046/j.1537-2995.2001.41121515.xPubMed

17.

d'Almeida MS, Jagger J, Duggan M, White M, Ellis C, Chin-Yee IH: A comparison of biochemical and functional alterations of rat and human erythrocytes stored in CPDA-1 for 29 days: implications for animal models of transfusion. Transfus Med 2000, 10: 291-303. 10.1046/j.1365-3148.2000.00267.xPubMed

18.

van de Watering L: Pitfalls in the current published observational literature on the effects of red blood cell storage. Transfusion 2011, 51: 1847-1854. 10.1111/j.1537-2995.2010.03015.xPubMed

19.

Spinella PC, Sparrow RL, Hess JR, Norris PJ: Properties of stored red blood cells: understanding immune and vascular reactivity. Transfusion 2011, 51: 894-900. 10.1111/j.1537-2995.2011.03103.xPubMedCentralPubMed

20.

Wang D, Sun J, Solomon SB, Klein HG, Natanson C: Transfusion of older stored blood and risk of death: a meta-analysis. Transfusion 2012, 52: 1184-1195. 10.1111/j.1537-2995.2011.03466.xPubMed

21.

Vamvakas EC: Meta-analysis of clinical studies of the purported deleterious effects of "old" (versus "fresh") red blood cells: are we at equipoise? Transfusion 2010, 50: 600-610.PubMed

22.

Vamvakas EC: Purported deleterious effects of "old" versus "fresh" red blood cells: an updated meta-analysis. Transfusion 2011, 51: 1122-1123. 10.1111/j.1537-2995.2010.03017.xPubMed

23.

Lelubre C, Vincent JL: Red blood cell transfusion in the critically ill patient. Ann Intensive Care 2011, 1: 43. 10.1186/2110-5820-1-43PubMedCentralPubMed

24.

Hess JR: An update on solutions for red cell storage. Vox Sang 2006, 91: 13-19. 10.1111/j.1423-0410.2006.00778.xPubMed

25.

Moher D, Liberati A, Tetzlaff J, Altman DG: Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med 2009, 6: e1000097. 10.1371/journal.pmed.1000097PubMedCentralPubMed

26.

Basran S, Frumento RJ, Cohen A, Lee S, Du Y, Nishanian E, Kaplan HS, Stafford-Smith M, Bennett-Guerrero E: The association between duration of storage of transfused red blood cells and morbidity and mortality after reoperative cardiac surgery. Anesth Analg 2006, 103: 15-20. 10.1213/01.ane.0000221167.58135.3dPubMed

27.

Basran S, Frumento R, Cohen A, Lee S, Du Y, Nishanian E, Kaplan HS, Stafford-Smith M, Bennett-Guerrero E: Request for retraction. Anesth Analg 2009, 108: 1991.PubMed

28.

Kor DJ, Kashyap R, Weiskopf RB, Wilson GA, van Buskirk CM, Winters JL, Malinchoc M, Hubmayr RD, Gajic O: Fresh red blood cell transfusion and short-term pulmonary, immunologic, and coagulation status: a randomized clinical trial. Am J Respir Crit Care Med 2012, 185: 842-850. 10.1164/rccm.201107-1332OCPubMedCentralPubMed

29.

Pettila V, Westbrook AJ, Nichol AD, Bailey MJ, Wood EM, Syres G, Phillips LE, Street A, French C, Murray L, Orford N, Santamaria JD, Bellomo R, Cooper DJ: Age of red blood cells and mortality in the critically ill. Crit Care 2011, 15: R116. 10.1186/cc10142PubMedCentralPubMed

30.

Edgren G, Kamper-Jorgensen M, Eloranta S, Rostgaard K, Custer B, Ullum H, Murphy EL, Busch MP, Reilly M, Melbye M, Hjalgrim H, Nyren O: Duration of red blood cell storage and survival of transfused patients. Transfusion 2010, 50: 1185-1195. 10.1111/j.1537-2995.2010.02583.xPubMedCentralPubMed

31.

Saager L, Turan A, Dalton JE, Figueroa PI, Sessler DI, Kurz A: Erythrocyte storage duration is not associated with increased mortality in noncardiac surgical patients: a retrospective analysis of 6,994 patients. Anesthesiology 2013, 118: 51-58. 10.1097/ALN.0b013e3182746ba4PubMed

32.

Koch CG, Li L, Sessler DI, Figueroa P, Hoeltge GA, Mihaljevic T, Blackstone EH: Duration of red-cell storage and complications after cardiac surgery. N Engl J Med 2008, 358: 1229-1239. 10.1056/NEJMoa070403PubMed

33.

Dzik W: Fresh blood for everyone? Balancing availability and quality of stored RBCs. Transfus Med 2008, 18: 260-265. 10.1111/j.1365-3148.2008.00870.xPubMed

34.

Benjamin RJ, Dodd RY: Red-cell storage and complications of cardiac surgery. N Engl J Med 2008, 358: 2840-2841.PubMed

35.

Frenzel T, Sibrowski W, Westphal M: Red-cell storage and complications of cardiac surgery. N Engl J Med 2008, 358: 2841-2842.PubMed

36.

Zimrin AB, Hess JR: Current issues relating to the transfusion of stored red blood cells. Vox Sang 2009, 96: 93-103. 10.1111/j.1423-0410.2008.01117.xPubMed

37.

Jy W, Ricci M, Shariatmadar S, Gomez-Marin O, Horstman LH, Ahn YS: Microparticles in stored red blood cells as potential mediators of transfusion complications. Transfusion 2011, 51: 886-893. 10.1111/j.1537-2995.2011.03099.xPubMedCentralPubMed

38.

van de Watering L, Lorinser J, Versteegh M, Westendord R, Brand A: Effects of storage time of red blood cell transfusions on the prognosis of coronary artery bypass graft patients. Transfusion 2006, 46: 1712-1718. 10.1111/j.1537-2995.2006.00958.xPubMed

39.

McKenny M, Ryan T, Tate H, Graham B, Young VK, Dowd N: Age of transfused blood is not associated with increased postoperative adverse outcome after cardiac surgery. Br J Anaesth 2011, 106: 643-649. 10.1093/bja/aer029PubMed

40.

van Straten AH, Soliman Hamad MA, van Zundert AA, Martens EJ, ter Woorst JF, de Wolf AM, Scharnhorst V: Effect of duration of red blood cell storage on early and late mortality after coronary artery bypass grafting. J Thorac Cardiovasc Surg 2011, 141: 231-237. 10.1016/j.jtcvs.2010.02.059PubMed

41.

Yap CH, Lau L, Krishnaswamy M, Gaskell M, Yii M: Age of transfused red cells and early outcomes after cardiac surgery. Ann Thorac Surg 2008, 86: 554-559. 10.1016/j.athoracsur.2008.04.040PubMed

42.

Purdy FR, Tweeddale MG, Merrick PM: Association of mortality with age of blood transfused in septic ICU patients. Can J Anaesth 1997, 44: 1256-1261. 10.1007/BF03012772PubMed

43.

Dessertaine G, Hammer L, Chenais F, Remy J, Schwebel C, Tabah A, Ara-Somohano C, Bonadona A, Hamidfar-Roy R, Barnoud D, Timsit JF: [Does red blood cell storage time still influence ICU survival?]. Transfus Clin Biol 2008, 15: 154-159. 10.1016/j.tracli.2008.06.001PubMed

44.

Weinberg JA, McGwin G Jr, Griffin RL, Huynh VQ, Cherry SA, Marques MB, Reiff DA, Kerby JD, Rue LW: Age of transfused blood: an independent predictor of mortality despite universal leukoreduction. J Trauma 2008, 65: 279-282. 10.1097/TA.0b013e31817c9687PubMed

45.

Weinberg JA, McGwin G Jr, Vandromme MJ, Marques MB, Melton SM, Reiff DA, Kerby JD, Rue LW: Duration of red cell storage influences mortality after trauma. J Trauma 2010, 69: 1427-1431. 10.1097/TA.0b013e3181fa0019PubMedCentralPubMed

46.

Weinberg JA, McGwin G Jr, Marques MB, Cherry SA, Reiff DA, Kerby JD, Rue LW: Transfusions in the less severely injured: does age of transfused blood affect outcomes? J Trauma 2008, 65: 794-798. 10.1097/TA.0b013e318184aa11PubMed

47.

Spinella PC, Carroll CL, Staff I, Gross R, McQuay J, Keibel L, Wade CE, Holcomb JB: Duration of red blood cell storage is associated with increased incidence of deep vein thrombosis and in hospital mortality in patients with traumatic injuries. Crit Care 2009, 13: R151. 10.1186/cc8050PubMedCentralPubMed

48.

Murrell Z, Haukoos JS, Putnam B, Klein SR: The effect of older blood on mortality, need for ICU care, and the length of ICU stay after major trauma. Am Surg 2005, 71: 781-785.PubMed

49.

Hassan M, Pham TN, Cuschieri J, Warner KJ, Nester T, Maier RV, Shalhub S, O'Keefe GE: The association between the transfusion of older blood and outcomes after trauma. Shock 2011, 35: 3-8. 10.1097/SHK.0b013e3181e76274PubMedCentralPubMed

50.

Eikelboom JW, Cook RJ, Liu Y, Heddle NM: Duration of red cell storage before transfusion and in-hospital mortality. Am Heart J 2010, 159: 737-743. 10.1016/j.ahj.2009.12.045PubMed

51.

Robinson SD, Janssen C, Fretz EB, Berry B, Chase AJ, Siega AD, Carere RG, Fung A, Simkus G, Klinke WP, Hilton JD: Red blood cell storage duration and mortality in patients undergoing percutaneous coronary intervention. Am Heart J 2010, 159: 876-881. 10.1016/j.ahj.2010.02.018PubMed

52.

Dunn LK, Thiele RH, Ma JZ, Sawyer RG, Nemergut EC: Duration of red blood cell storage and outcomes following orthotopic liver transplantation. Liver Transpl 2012, 18: 475-481. 10.1002/lt.23379PubMed

53.

Mynster T, Nielsen HJ: Storage time of transfused blood and disease recurrence after colorectal cancer surgery. Dis Colon Rectum 2001, 44: 955-964. 10.1007/BF02235483PubMed

54.

Kekre N, Chou A, Tokessey M, Doucette S, Tinmouth A, Tay J, Allan DS: Storage time of transfused red blood cells and impact on clinical outcomes in hematopoietic stem cell transplantation. Transfusion 2011, 51: 2488-2494. 10.1111/j.1537-2995.2011.03166.xPubMed

55.

Leal-Noval SR, Jara-Lopez I, Garcia-Garmendia JL, Marin-Niebla A, Herruzo-Aviles A, Camacho-Larana P, Loscertales J: Influence of erythrocyte concentrate storage time on postsurgical morbidity in cardiac surgery patients. Anesthesiology 2003, 98: 815-822. 10.1097/00000542-200304000-00005PubMed

56.

Vamvakas EC, Carven JH: Length of storage of transfused red cells and postoperative morbidity in patients undergoing coronary artery bypass graft surgery. Transfusion 2000, 40: 101-109. 10.1046/j.1537-2995.2000.40010101.xPubMed

57.

Sanders J, Patel S, Cooper J, Berryman J, Farrar D, Mythen M, Montgomery HE: Red blood cell storage is associated with length of stay and renal complications after cardiac surgery. Transfusion 2011, 51: 2286-2294. 10.1111/j.1537-2995.2011.03170.xPubMed

58.

Keller ME, Jean R, LaMorte WW, Millham F, Hirsch E: Effects of age of transfused blood on length of stay in trauma patients: a preliminary report. J Trauma 2002, 53: 1023-1025. 10.1097/00005373-200211000-00037PubMed

59.

Vamvakas EC, Carven JH: Transfusion and postoperative pneumonia in coronary artery bypass graft surgery: effect of the length of storage of transfused red cells. Transfusion 1999, 39: 701-710. 10.1046/j.1537-2995.1999.39070701.xPubMed

60.

Andreasen JJ, Dethlefsen C, Modrau IS, Baech J, Schonheyder HC, Moeller JK, Johnsen SP: Storage time of allogeneic red blood cells is associated with risk of severe postoperative infection after coronary artery bypass grafting. Eur J Cardiothorac Surg 2011, 39: 329-334. 10.1016/j.ejcts.2010.06.019PubMed

61.

Edna TH, Bjerkeset T: Association between transfusion of stored blood and infective bacterial complications after resection for colorectal cancer. Eur J Surg 1998, 164: 449-456.PubMed

62.

Mynster T, Nielsen HJ: The impact of storage time of transfused blood on postoperative infectious complications in rectal cancer surgery. Danish RANX05 Colorectal Cancer Study Group. Scand J Gastroenterol 2000, 35: 212-217. 10.1080/003655200750024416PubMed

63.

Vandromme MJ, McGwin G Jr, Marques MB, Kerby JD, Rue LW, Weinberg JA: Transfusion and pneumonia in the trauma intensive care unit: an examination of the temporal relationship. J Trauma 2009, 67: 97-101. 10.1097/TA.0b013e3181a5a8f9PubMed

64.

Offner PJ, Moore EE, Biffl WL, Johnson JL, Silliman CC: Increased rate of infection associated with transfusion of old blood after severe injury. Arch Surg 2002, 137: 711-716. 10.1001/archsurg.137.6.711PubMed

65.

Juffermans NP, Vlaar AP, Prins DJ, Goslings JC, Binnekade JM: The age of red blood cells is associated with bacterial infections in critically ill trauma patients. Blood Transfus 2012, 10: 290-295.PubMedCentralPubMed

66.

Taylor RW, O'Brien J, Trottier SJ, Manganaro L, Cytron M, Lesko MF, Arnzen K, Cappadoro C, Fu M, Plisco MS, Sadaka FG, Veremakis C: Red blood cell transfusions and nosocomial infections in critically ill patients. Crit Care Med 2006, 34: 2302-2308. 10.1097/01.CCM.0000234034.51040.7FPubMed

67.

Juffermans NP, Prins DJ, Vlaar AP, Nieuwland R, Binnekade JM: Transfusion-related risk of secondary bacterial infections in sepsis patients: a retrospective cohort study. Shock 2011, 35: 355-359. 10.1097/SHK.0b013e3182086094PubMed

68.

Zallen G, Offner PJ, Moore EE, Blackwell J, Ciesla DJ, Gabriel J, Denny C, Silliman CC: Age of transfused blood is an independent risk factor for postinjury multiple organ failure. Am J Surg 1999, 178: 570-572. 10.1016/S0002-9610(99)00239-1PubMed

69.

Weiskopf RB, Feiner J, Toy P, Twiford J, Shimabukuro D, Lieberman J, Looney MR, Lowell CA, Gropper MA: Fresh and stored red blood cell transfusion equivalently induce subclinical pulmonary gas exchange deficit in normal humans. Anesth Analg 2012, 114: 511-519. 10.1213/ANE.0b013e318241fcd5PubMedCentralPubMed

70.

Gajic O, Rana R, Mendez JL, Rickman OB, Lymp JF, Hubmayr RD, Moore SB: Acute lung injury after blood transfusion in mechanically ventilated patients. Transfusion 2004, 44: 1468-1474. 10.1111/j.1537-2995.2004.04053.xPubMed

71.

Marik PE, Sibbald WJ: Effect of stored-blood transfusion on oxygen delivery in patients with sepsis. JAMA 1993, 269: 3024-3029. 10.1001/jama.1993.03500230106037PubMed

72.

Fernandes CJ Jr, Akamine N, De Marco FV, De Souza JA, Lagudis S, Knobel E: Red blood cell transfusion does not increase oxygen consumption in critically ill septic patients. Crit Care 2001, 5: 362-367. 10.1186/cc1070PubMedCentralPubMed

73.

Walsh TS, McArdle F, McLellan SA, Maciver C, Maginnis M, Prescott RJ, McClelland DB: Does the storage time of transfused red blood cells influence regional or global indexes of tissue oxygenation in anemic critically ill patients? Crit Care Med 2004, 32: 364-371. 10.1097/01.CCM.0000108878.23703.E0PubMed

74.

Marik P: Does the age of blood matter? Crit Care Med 2004, 32: 1442-1443.PubMed

75.

Sakr Y, Chierego M, Piagnerelli M, Verdant C, Dubois MJ, Koch M, Creteur J, Gullo A, Vincent JL, De Backer D: Microvascular response to red blood cell transfusion in patients with severe sepsis. Crit Care Med 2007, 35: 1639-1644. 10.1097/01.CCM.0000269936.73788.32PubMed

76.

Yuruk K, Milstein DM, Bezemer R, Bartels SA, Biemond BJ, Ince C: Transfusion of banked red blood cells and the effects on hemorrheology and microvascular hemodynamics in anemic hematology outpatients. Transfusion 2012, in press. doi: 10.1111/j.1537-2995.2012.03905

77.

Leal-Noval SR, Munoz-Gomez M, Arellano-Orden V, Marin-Caballos A, maya-Villar R, Marin A, Puppo-Moreno A, Ferrandiz-Millon C, Flores-Cordero JM, Murillo-Cabezas F: Impact of age of transfused blood on cerebral oxygenation in male patients with severe traumatic brain injury. Crit Care Med 2008, 36: 1290-1296. 10.1097/CCM.0b013e3181692dfcPubMed

78.

Netzer G, Dutton RP, Hess JR: Right data, wrong conclusions. Crit Care Med 2008, 36: 1383-1384. 10.1097/CCM.0b013e31816a10a3PubMed

79.

Kiraly LN, Underwood S, Differding JA, Schreiber MA: Transfusion of aged packed red blood cells results in decreased tissue oxygenation in critically injured trauma patients. J Trauma 2009, 67: 29-32. 10.1097/TA.0b013e3181af6a8cPubMed

80.

Santora RJ, Moore FA: Monitoring trauma and intensive care unit resuscitation with tissue hemoglobin oxygen saturation. Crit Care 2009, (Suppl 5):S10.

81.

Creteur J, Neves AP, Vincent JL: Near-infrared spectroscopy technique to evaluate the effects of red blood cell transfusion on tissue oxygenation. Crit Care 2009, (Suppl 5):S11.

82.

Berra L, Coppadoro A, Yu B, Lei C, Spagnolli E, Steinbicker AU, Bloch KD, Lin T, Sammy FY, Warren HS, Fernandez BO, Feelisch M, Dzik WH, Stowell CP, Zapol WM: Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology 2012, 117: 56-63. 10.1097/ALN.0b013e31825575e6PubMedCentralPubMed

83.

Roberson RS, Lockhart E, Shapiro NI, Bandarenko N, McMahon TJ, Massey MJ, White WD, Bennett-Guerrero E: Impact of transfusion of autologous 7- versus 42-day-old AS-3 red blood cells on tissue oxygenation and the microcirculation in healthy volunteers. Transfusion 2012, 52: 2459-2464. 10.1111/j.1537-2995.2012.03615.xPubMedCentralPubMed

84.

Kopterides P, Theodorakopoulou M, Nikitas N, Ilias I, Vassiliadi DA, Orfanos SE, Tsangaris I, Maniatis NA, Tsantes AE, Travlou A, Dimitriadis G, Armaganidis A, Ungerstedt U, Dimopoulou I: Red blood cell transfusion affects microdialysis-assessed interstitial lactate/pyruvate ratio in critically ill patients with late sepsis. Intensive Care Med 2012, 38: 1843-1850. 10.1007/s00134-012-2635-8PubMed

85.

Katsios C, Griffith L, Spinella P, Lacroix J, Crowther M, Hebert P, Meade M, Geerts W, Rabbat C, Cook D: Red blood cell transfusion and increased length of storage are not associated with deep vein thrombosis in medical and surgical critically ill patients: a prospective observational cohort study. Crit Care 2011, 15: R263. 10.1186/cc10526PubMedCentralPubMed

86.

Naidech AM, Liebling SM, Duran IM, Ault ML: Packed red blood cell age does not impact adverse events or outcomes after subarachnoid haemorrhage. Transfus Med 2011, 21: 130-133. 10.1111/j.1365-3148.2010.01048.xPubMed

87.

Wasser MN, Houbiers JG, D'Amaro J, Hermans J, Huysmans HA, van Konijnenburg GC, Brand A: The effect of fresh versus stored blood on post-operative bleeding after coronary bypass surgery: a prospective randomized study. Br J Haematol 1989, 72: 81-84. 10.1111/j.1365-2141.1989.tb07656.xPubMed

88.

Weiskopf RB, Feiner J, Hopf H, Lieberman J, Finlay HE, Quah C, Kramer JH, Bostrom A, Toy P: Fresh blood and aged stored blood are equally efficacious in immediately reversing anemia-induced brain oxygenation deficits in humans. Anesthesiology 2006, 104: 911-920. 10.1097/00000542-200605000-00005PubMed

89.

Cata JP, Klein EA, Hoeltge GA, Dalton JE, Mascha E, O'Hara J, Russell A, Kurz A, Ben-Elihayhu S, Sessler DI: Blood storage duration and biochemical recurrence of cancer after radical prostatectomy. Mayo Clin Proc 2011, 86: 120-127. 10.4065/mcp.2010.0313PubMedCentralPubMed

90.

Weinberg JA, Barnum SR, Patel RP: Red blood cell age and potentiation of transfusion-related pathology in trauma patients. Transfusion 2011, 51: 867-873. 10.1111/j.1537-2995.2011.03098.xPubMedCentralPubMed

91.

Pereira A: Will clinical studies elucidate the connection between the length of storage of transfused red blood cells and clinical outcomes? An analysis based on the simulation of randomized controlled trials. Transfusion 2013, 53: 34-40. 10.1111/j.1537-2995.2012.03656.xPubMed

92.

Middelburg RA, van de Watering LM, van der Bom JG: Blood transfusions: good or bad? Confounding by indication, an underestimated problem in clinical transfusion research. Transfusion 2010, 50: 1181-1183. 10.1111/j.1537-2995.2010.02675.xPubMed

93.

Jenkins PV, O'Donnell JS: ABO blood group determines plasma von Willebrand factor levels: a biologic function after all? Transfusion 2006, 46: 1836-1844. 10.1111/j.1537-2995.2006.00975.xPubMed

94.

Ioannidis JP, Lau J: Pooling research results: benefits and limitations of meta-analysis. Jt Comm J Qual Improv 1999, 25: 462-469.PubMed

95.

Flegel WA: Fresh blood for transfusion: how old is too old for red blood cell units? Blood Transfus 2012, 10: 247-251.PubMedCentralPubMed

96.

Heddle NM, Cook RJ, Arnold DM, Crowther MA, Warkentin TE, Webert KE, Hirsh J, Barty RL, Liu Y, Lester C, Eikelboom JW: The effect of blood storage duration on in-hospital mortality: a randomized controlled pilot feasibility trial. Transfusion 2012, 52: 1203-1212. 10.1111/j.1537-2995.2011.03521.xPubMed

97.

Aubron C, Syres G, Nichol A, Bailey M, Board J, Magrin G, Murray L, Presneill J, Sutton J, Vallance S, Morrison S, Bellomo R, Cooper DJ: A pilot feasibility trial of allocation of freshest available red blood cells versus standard care in critically ill patients. Transfusion 2012, 52: 1196-1202. 10.1111/j.1537-2995.2011.03437.xPubMed

98.

Lacroix J, Hebert P, Fergusson D, Tinmouth A, Blajchman MA, Callum J, Cook D, Marshall JC, McIntyre L, Turgeon AF: The Age of Blood Evaluation (ABLE) randomized controlled trial: study design. Transfus Med Rev 2011, 25: 197-205. 10.1016/j.tmrv.2011.03.001PubMed

99.

Steiner ME, Assmann SF, Levy JH, Marshall J, Pulkrabek S, Sloan SR, Triulzi D, Stowell CP: Addressing the question of the effect of RBC storage on clinical outcomes: the Red Cell Storage Duration Study (RECESS) (Section 7). Transfus Apher Sci 2010, 43: 107-116. 10.1016/j.transci.2010.05.014PubMedCentralPubMed

100.

Schulman CI, Nathe K, Brown M, Cohn SM: Impact of age of transfused blood in the trauma patient. J Trauma 2002, 52: 1224-1225. 10.1097/00005373-200206000-00036PubMed

101.

Hebert PC, Chin-Yee I, Fergusson D, Blajchman M, Martineau R, Clinch J, Olberg B: A pilot trial evaluating the clinical effects of prolonged storage of red cells. Anesth Analg 2005, 100: 1433-1438. 10.1213/01.ANE.0000148690.48803.27PubMed

102.

Bennett-Guerrero E, Stafford-Smith M, Waweru PM, Bredehoeft SJ, Campbell ML, Haley NR, Phillips-Bute B, Newman MF, Bandarenko N: A prospective, double-blind, randomized clinical feasibility trial of controlling the storage age of red blood cells for transfusion in cardiac surgical patients. Transfusion 2009, 49: 1375-1383. 10.1111/j.1537-2995.2009.02152.xPubMed

103.

Fogh-Andersen N, Mogensen F: On the safety of using stored bank blood for chronic hemodialysis patients. Transfusion 1984, 24: 505-507. 10.1046/j.1537-2995.1984.24685066811.xPubMed

104.

Luten M, Roerdinkholder-Stoelwinder B, Schaap NP, De Grip WJ, Bos HJ, Bosman GJ: Survival of red blood cells after transfusion: a comparison between red cells concentrates of different storage periods. Transfusion 2008, 48: 1478-1485. 10.1111/j.1537-2995.2008.01734.xPubMed

105.

Pieracci FM, Moore EE, Chin T, Townsend N, Gonzalez E, Burlew CC, Barnett CC Jr: The age of transfused blood predicts hematocrit response among critically ill surgical patients. Am J Surg 2012, 204: 269-273. 10.1016/j.amjsurg.2011.10.017PubMedCentralPubMed

106.

Hoh H, Umpleby H, Cooper A, Taylor I: Recurrence of colorectal cancer and perioperative blood transfusion. Is blood storage time important? Dis Colon Rectum 1990, 33: 127-130. 10.1007/BF02055541PubMed

107.

Lebiedz P, Glasmeyer S, Hilker E, Yilmaz-Neuhaus A, Karaboutas T, Reinecke H, Sibrowski W, Nofer JR: Influence of red blood cell storage time on clinical course and cytokine profile in septic shock patients. Transfus Med Hemother 2012, 39: 271-276. 10.1159/000339807PubMedCentralPubMed

108.

Zubair AC: Clinical impact of blood storage lesions. Am J Hematol 2010, 85: 117-122.PubMed

109.

Roback JD: Vascular effects of the red blood cell storage lesion. Hematology Am Soc Hematol Educ Program 2011, 2011: 475-479. 10.1182/asheducation-2011.1.475PubMed

110.

Reynolds JD, Ahearn GS, Angelo M, Zhang J, Cobb F, Stamler JS: S-nitrosohemoglobin deficiency: a mechanism for loss of physiological activity in banked blood. Proc Natl Acad Sci USA 2007, 104: 17058-17062. 10.1073/pnas.0707958104PubMedCentralPubMed

111.

Kay MM, Flowers N, Goodman J, Bosman G: Alteration in membrane protein band 3 associated with accelerated erythrocyte aging. Proc Natl Acad Sci USA 1989, 86: 5834-5838. 10.1073/pnas.86.15.5834PubMedCentralPubMed

112.

Grimshaw K, Sahler J, Spinelli SL, Phipps RP, Blumberg N: New frontiers in transfusion biology: identification and significance of mediators of morbidity and mortality in stored red blood cells. Transfusion 2011, 51: 874-880. 10.1111/j.1537-2995.2011.03095.xPubMedCentralPubMed

113.

Basora M, Pereira A, Soriano A, Martinez-Pastor JC, Sanchez-Etayo G, Tio M, Salazar F: Allogeneic blood transfusion does not increase the risk of wound infection in total knee arthroplasty. Vox Sang 2010, 98: 124-129. 10.1111/j.1423-0410.2009.01242.xPubMed

Title: Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review
Authors: Christophe Lelubre
Jean-Louis Vincent
Publication date: 01-04-2013
Publisher: BioMed Central
Published in: Critical Care / Issue 2/2013
Electronic ISSN: 1364-8535
DOI: https://doi.org/10.1186/cc12600

At a glance: The STEP trials

Springer Medicine

Relationship between red cell storage duration and outcomes in adults receiving red cell transfusions: a systematic review

Abstract

Introduction

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Introduction

Methods

Results

Conclusions

Please log in to get access to this content

Other articles of this Issue 2/2013

Accuracy of blood-glucose measurements using glucose meters and arterial blood gas analyzers in critically ill adult patients: systematic review

n-3 fatty acids, γ-linolenic acid, and antioxidants in sepsis

The STOP the Bleeding Campaign

Dysnatremia and mortality: do sweat the small stuff...

A human model of intra-abdominal hypertension: even slightly elevated pressures lead to increased acute systemic inflammation and signs of acute kidney injury

Recognition of hypovolemic shock: using base deficit to think outside of the ATLS box