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Journal of Cardiovascular Magnetic Resonance

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Open Access 01-01-2017 | Research

Relationship between native papillary muscle T₁ time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy

Authors: Shingo Kato, Shiro Nakamori, Sébastien Roujol, Francesca N. Delling, Shadi Akhtari, Jihye Jang, Tamer Basha, Sophie Berg, Kraig V. Kissinger, Beth Goddu, Warren J. Manning, Reza Nezafat

Published in: Journal of Cardiovascular Magnetic Resonance | Issue 1/2017

Abstract

Background

Functional mitral regurgitation is one of the severe complications of non-ischemic dilated cardiomyopathy (DCM). Non-contrast native T₁ mapping has emerged as a non-invasive method to evaluate myocardial fibrosis. We sought to evaluate the potential relationship between papillary muscle T₁ time and mitral regurgitation in DCM patients.

Methods

Forty DCM patients (55 ± 13 years) and 20 healthy adult control subjects (54 ± 13 years) were studied. Native T₁ mapping was performed using a slice interleaved T₁ mapping sequence (STONE) which enables acquisition of 5 slices in the short-axis plane within a 90 s free-breathing scan. We measured papillary muscle diameter, length and shortening. DCM patients were allocated into 2 groups based on the presence or absence of functional mitral regurgitation.

Results

Papillary muscle T₁ time was significantly elevated in DCM patients with mitral regurgitation (n = 22) in comparison to those without mitral regurgitation (n = 18) (anterior papillary muscle: 1127 ± 36 msec vs 1063 ± 16 msec, p < 0.05; posterior papillary muscle: 1124 ± 30 msec vs 1062 ± 19 msec, p < 0.05), but LV T₁ time was similar (1129 ± 38 msec vs 1134 ± 58 msec, p = 0.93). Multivariate linear regression analysis showed that papillary muscle native T₁ time (β = 0.10, 95 % CI: 0.05–0.17, p < 0.05) is significantly correlated with mitral regurgitant fraction. Elevated papillary muscle T₁ time was associated with larger diameter, longer length and decreased papillary muscle shortening (all p values <0.05).

Conclusions

In DCM, papillary muscle native T₁ time is significantly elevated and related to mitral regurgitant fraction.

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Title: Relationship between native papillary muscle T1 time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy
Authors: Shingo Kato
Shiro Nakamori
Sébastien Roujol
Francesca N. Delling
Shadi Akhtari
Jihye Jang
Tamer Basha
Sophie Berg
Kraig V. Kissinger
Beth Goddu
Warren J. Manning
Reza Nezafat
Publication date: 01-01-2017
Publisher: BioMed Central
Published in: Journal of Cardiovascular Magnetic Resonance / Issue 1/2017
Electronic ISSN: 1532-429X
DOI: https://doi.org/10.1186/s12968-016-0301-y

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Relationship between native papillary muscle T₁ time and severity of functional mitral regurgitation in patients with non-ischemic dilated cardiomyopathy

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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