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01-06-2016 | Original Article

Relationship between motor corticospinal excitability and ventilatory response during intense exercise

Authors: Takahiro Yunoki, Ryouta Matsuura, Ryo Yamanaka, Roghayyeh Afroundeh, Chang-shun Lian, Kazuki Shirakawa, Yoshinori Ohtsuka, Tokuo Yano

Published in: European Journal of Applied Physiology | Issue 6/2016

Abstract

Purpose

Effort sense has been suggested to be involved in the hyperventilatory response during intense exercise (IE). However, the mechanism by which effort sense induces an increase in ventilation during IE has not been fully elucidated. The aim of this study was to determine the relationship between effort-mediated ventilatory response and corticospinal excitability of lower limb muscle during IE.

Methods

Eight subjects performed 3 min of cycling exercise at 75–85 % of maximum workload twice (IE_1st and IE_2nd). IE_2nd was performed after 60 min of resting recovery following 45 min of submaximal cycling exercise at the workload corresponding to ventilatory threshold. Vastus lateralis muscle response to transcranial magnetic stimulation of the motor cortex (motor evoked potentials, MEPs), effort sense of legs (ESL, Borg 0–10 scale), and ventilatory response were measured during the two IEs.

Results

The slope of ventilation (l/min) against CO₂ output (l/min) during IE_2nd (28.0 ± 5.6) was significantly greater than that (25.1 ± 5.5) during IE_1st. Mean ESL during IE was significantly higher in IE_2nd (5.25 ± 0.89) than in IE_1st (4.67 ± 0.62). Mean MEP (normalized to maximal M-wave) during IE was significantly lower in IE_2nd (66 ± 22 %) than in IE_1st (77 ± 24 %). The difference in mean ESL between the two IEs was significantly (p < 0.05, r = −0.82) correlated with the difference in mean MEP between the two IEs.

Conclusions

The findings suggest that effort-mediated hyperventilatory response to IE may be associated with a decrease in corticospinal excitability of exercising muscle.

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Title: Relationship between motor corticospinal excitability and ventilatory response during intense exercise
Authors: Takahiro Yunoki
Ryouta Matsuura
Ryo Yamanaka
Roghayyeh Afroundeh
Chang-shun Lian
Kazuki Shirakawa
Yoshinori Ohtsuka
Tokuo Yano
Publication date: 01-06-2016
Publisher: Springer Berlin Heidelberg
Published in: European Journal of Applied Physiology / Issue 6/2016
Print ISSN: 1439-6319
Electronic ISSN: 1439-6327
DOI: https://doi.org/10.1007/s00421-016-3374-2

At a glance: The STEP trials

Springer Medicine

Relationship between motor corticospinal excitability and ventilatory response during intense exercise

Abstract

Purpose

Methods

Results

Conclusions

At a glance: The STEP trials

Springer Medicine

Abstract

Purpose

Methods

Results

Conclusions

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