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European Archives of Psychiatry and Clinical Neuroscience

Published in:

01-12-2019 | Original Paper

Relationship between duration of untreated prodromal symptoms and symptomatic and functional recovery

Authors: TianHong Zhang, LiHua Xu, YingYing Tang, HuiRu Cui, XiaoChen Tang, YanYan Wei, Yan Wang, Qiang Hu, ZhenYing Qian, XiaoHua Liu, ChunBo Li, JiJun Wang

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 8/2019

Abstract

Our previous study has found that a long duration of untreated prodromal symptoms (DUPrS) does not increase the conversion risk to psychosis in individuals with attenuated psychosis syndrome (APS). However, whether a long DUPrS will lead to other poor outcomes remains unknown. The purpose of this study was to analyse the association between the DUPrS and outcomes (symptomatic and functional recovery) in APS population. A post hoc analysis was performed in 391 individuals with APS as identified by the structured interview. APS subjects had follow-up interviews every 6 months for 2 years following diagnosis. Poor functional outcome was defined as a Global Assessment of Functioning (GAF) score less than 60 at the time of follow-up. Poor symptomatic outcome was defined as at least one of the positive symptoms rated scores of 3 or higher. A post hoc analysis was performed in 391 individuals with APS as identified by the structured interview. APS subjects had follow-up interviews every 6 months for 2 years following diagnosis. Poor functional outcome was defined as a Global Assessment of Functioning (GAF) score less than 60 at the time of follow-up. Poor symptomatic outcome was defined as at least one of the positive symptoms rated scores of 3 or higher. Of total 391 individuals, 334 were followed up for 2 years to assess clinical outcome, 82 (24.6%) had shown conversion to psychosis, 79 (23.7%) met the criteria of poor functioning outcome, and 145 (43.4%) met the criteria of poor symptomatic outcome. A significant correlation between GAF scores and DUPrS was observed in the non-converter group, but not in the converters. Individuals with APS who had a longer DUPrS were correlated with poorer functional outcome. However, it was not correlated with poorer symptomatic outcome. While a longer DUPrS was not related to poor symptomatic outcome, it was significantly related to poor functional outcome. Our findings highlight the importance of reducing DUPrS to decrease future functional impairment in populations at risk for psychosis.

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Title: Relationship between duration of untreated prodromal symptoms and symptomatic and functional recovery
Authors: TianHong Zhang
LiHua Xu
YingYing Tang
HuiRu Cui
XiaoChen Tang
YanYan Wei
Yan Wang
Qiang Hu
ZhenYing Qian
XiaoHua Liu
ChunBo Li
JiJun Wang
Publication date: 01-12-2019
Publisher: Springer Berlin Heidelberg
Published in: European Archives of Psychiatry and Clinical Neuroscience / Issue 8/2019
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI: https://doi.org/10.1007/s00406-018-0917-z

At a glance: The STEP trials

Springer Medicine

Relationship between duration of untreated prodromal symptoms and symptomatic and functional recovery

Abstract

At a glance: The STEP trials

Springer Medicine

Abstract

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