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European Archives of Psychiatry and Clinical Neuroscience
Published in: European Archives of Psychiatry and Clinical Neuroscience 3/2014

01-04-2014 | Original Paper

Relational memory and hippocampal function in psychotic bipolar disorder

Authors: Suzanne N. Avery, Lisa E. Williams, Austin A. Woolard, Stephan Heckers

Published in: European Archives of Psychiatry and Clinical Neuroscience | Issue 3/2014

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Abstract

Recent cognitive, genetic, and histological studies have highlighted significant overlap between psychotic bipolar disorder and schizophrenia. Specifically, both bipolar disorder and schizophrenia are characterized by interneuron dysfunction within the hippocampus, an essential structure for relational memory. Relational memory impairments are a common feature of schizophrenia, but have yet to be investigated in psychotic bipolar disorder. Here, we tested the hypothesis that psychotic bipolar disorder is characterized by relational memory deficits. We used a transitive inference (TI) paradigm, previously employed to quantify relational memory deficits in schizophrenia, to assess relational memory performance in 17 patients with psychotic bipolar disorder and 22 demographically matched control participants. Functional magnetic resonance imaging was used to examine hippocampal activity during recognition memory in patients and controls. Hippocampal volumes were assessed by manual segmentation. In contrast to our hypothesis, we found similar TI performance, hippocampal volume, and hippocampal recruitment during recognition memory in both groups. Both psychotic bipolar disorder patients and controls exhibited a positive correlation between hippocampal volume and relational memory performance. These data indicate that relational memory impairments are not a shared feature of non-affective and affective psychosis.
Literature
1.
Keck PE Jr, McElroy SL, Havens JR, Altshuler LL, Nolen WA, Frye MA, Suppes T, Denicoff KD, Kupka R, Leverich GS, Rush AJ, Post RM (2003) Psychosis in bipolar disorder: phenomenology and impact on morbidity and course of illness. Compr Psychiatry 44(4):263–269CrossRefPubMed
2.
Goodwin FK, Jamison KR (1990) Manic-depressive Illness. Oxford University Press, New York, NY
3.
Bora E, Yucel M, Fornito A, Berk M, Pantelis C (2008) Major psychoses with mixed psychotic and mood symptoms: are mixed psychoses associated with different neurobiological markers? Acta Psychiatr Scand 118(3):172–187CrossRefPubMed
4.
Rosen LN, Rosenthal NE, Dunner DL, Fieve RR (1983) Social outcome compared in psychotic and nonpsychotic bipolar I patients. J Nerv Ment Dis 171(5):272–275CrossRefPubMed
5.
Rosenthal NE, Rosenthal LN, Stallone F, Fleiss J, Dunner DL, Fieve RR (1979) Psychosis as a predictor of response to lithium maintenance treatment in bipolar affective disorder. J Affect Disord 1(4):237–245CrossRefPubMed
6.
Tohen M, Waternaux CM, Tsuang MT, Hunt AT (1990) Four-year follow-up of twenty-four first-episode manic patients. J Affect Disord 19(2):79–86CrossRefPubMed
7.
Glahn DC, Bearden CE, Barguil M, Barrett J, Reichenberg A, Bowden CL, Soares JC, Velligan DI (2007) The neurocognitive signature of psychotic bipolar disorder. Biol Psychiatry 62(8):910–916CrossRefPubMed
8.
Simonsen C, Sundet K, Vaskinn A, Birkenaes AB, Engh JA, Faerden A, Jonsdottir H, Ringen PA, Opjordsmoen S, Melle I, Friis S, Andreassen OA (2011) Neurocognitive dysfunction in bipolar and schizophrenia spectrum disorders depends on history of psychosis rather than diagnostic group. Schizophr Bull 37(1):73–83PubMedCentralCrossRefPubMed
9.
Bora E, Yucel M, Pantelis C (2009) Cognitive endophenotypes of bipolar disorder: a meta-analysis of neuropsychological deficits in euthymic patients and their first-degree relatives. J Affect Disord 113(1–2):1–20CrossRefPubMed
10.
Arts B, Jabben N, Krabbendam L, van Os J (2008) Meta-analyses of cognitive functioning in euthymic bipolar patients and their first-degree relatives. Psychol Med 38(6):771–785CrossRefPubMed
11.
Robinson LJ, Thompson JM, Gallagher P, Goswami U, Young AH, Ferrier IN, Moore PB (2006) A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. J Affect Disord 93(1–3):105–115CrossRefPubMed
12.
Seidman LJ, Kremen WS, Koren D, Faraone SV, Goldstein JM, Tsuang MT (2002) A comparative profile analysis of neuropsychological functioning in patients with schizophrenia and bipolar psychoses. Schizophr Res 53(1–2):31–44CrossRefPubMed
13.
Reichenberg A, Harvey PD, Bowie CR, Mojtabai R, Rabinowitz J, Heaton RK, Bromet E (2009) Neuropsychological function and dysfunction in schizophrenia and psychotic affective disorders. Schizophr Bull 35(5):1022–1029PubMedCentralCrossRefPubMed
14.
Berrettini WH (2000) Susceptibility loci for bipolar disorder: overlap with inherited vulnerability to schizophrenia. Biol Psychiatry 47(3):245–251CrossRefPubMed
15.
Kendler KS, McGuire M, Gruenberg AM, O’Hare A, Spellman M, Walsh D (1993) The Roscommon Family Study. I. Methods, diagnosis of probands, and risk of schizophrenia in relatives. Arch Gen Psychiatry 50(7):527–540CrossRefPubMed
16.
Erlenmeyer-Kimling L, Adamo UH, Rock D, Roberts SA, Bassett AS, Squires-Wheeler E, Cornblatt BA, Endicott J, Pape S, Gottesman II (1997) The New York High-Risk Project. Prevalence and comorbidity of axis I disorders in offspring of schizophrenic parents at 25-year follow-up. Arch Gen Psychiatry 54(12):1096–1102PubMedCentralCrossRefPubMed
17.
Craddock N, O’Donovan MC, Owen MJ (2006) Genes for schizophrenia and bipolar disorder? Implications for psychiatric nosology. Schizophr Bull 32(1):9–16PubMedCentralCrossRefPubMed
18.
Craddock N, O’Donovan MC, Owen MJ (2009) Psychosis genetics: modeling the relationship between schizophrenia, bipolar disorder, and mixed (or “schizoaffective”) psychoses. Schizophr Bull 35(3):482–490PubMedCentralCrossRefPubMed
19.
Callicott JH, Straub RE, Pezawas L, Egan MF, Mattay VS, Hariri AR, Verchinski BA, Meyer-Lindenberg A, Balkissoon R, Kolachana B, Goldberg TE, Weinberger DR (2005) Variation in DISC1 affects hippocampal structure and function and increases risk for schizophrenia. Proc Natl Acad Sci USA 102(24):8627–8632PubMedCentralCrossRefPubMed
20.
Goes FS, Sanders LL, Potash JB (2008) The genetics of psychotic bipolar disorder. Curr Psychiatry Rep 10(2):178–189CrossRefPubMed
21.
Heckers S, Konradi C (2010) Hippocampal pathology in schizophrenia. Curr Top Behav Neurosci 4:529–553CrossRefPubMed
22.
Benes FM, Kwok EW, Vincent SL, Todtenkopf MS (1998) A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry 44(2):88–97CrossRefPubMed
23.
Konradi C, Yang CK, Zimmerman EI, Lohmann KM, Gresch P, Pantazopoulos H, Berretta S, Heckers S (2011) Hippocampal interneurons are abnormal in schizophrenia. Schizophr Res 131(1–3):165–173PubMedCentralCrossRefPubMed
24.
Konradi C, Zimmerman EI, Yang CK, Lohmann KM, Gresch P, Pantazopoulos H, Berretta S, Heckers S (2011) Hippocampal interneurons in bipolar disorder. Arch Gen Psychiatry 68(4):340–350PubMedCentralCrossRefPubMed
25.
Bartos M, Vida I, Jonas P (2007) Synaptic mechanisms of synchronized gamma oscillations in inhibitory interneuron networks. Nat Rev Neurosci 8(1):45–56CrossRefPubMed
26.
Lewis DA, Hashimoto T, Volk DW (2005) Cortical inhibitory neurons and schizophrenia. Nat Rev Neurosci 6(4):312–324CrossRefPubMed
27.
Martinez-Aran A, Torrent C, Tabares-Seisdedos R, Salamero M, Daban C, Balanza-Martinez V, Sanchez-Moreno J, Manuel GJ, Benabarre A, Colom F, Vieta E (2008) Neurocognitive impairment in bipolar patients with and without history of psychosis. J Clin Psychiatry 69(2):233–239CrossRefPubMed
28.
Kurtz MM, Gerraty RT (2009) A meta-analytic investigation of neurocognitive deficits in bipolar illness: profile and effects of clinical state. Neuropsychology 23(5):551–562PubMedCentralCrossRefPubMed
29.
Eichenbaum H (2000) A cortical–hippocampal system for declarative memory. Nat Rev Neurosci 1(1):41–50CrossRefPubMed
30.
31.
Deckersbach T, Savage CR, Reilly-Harrington N, Clark L, Sachs G, Rauch SL (2004) Episodic memory impairment in bipolar disorder and obsessive-compulsive disorder: the role of memory strategies. Bipolar Disord 6(3):233–244CrossRefPubMed
32.
Glahn DC, Bearden CE, Caetano S, Fonseca M, Najt P, Hunter K, Pliszka SR, Olvera RL, Soares JC (2005) Declarative memory impairment in pediatric bipolar disorder. Bipolar Disord 7(6):546–554CrossRefPubMed
33.
Bearden CE, Glahn DC, Monkul ES, Barrett J, Najt P, Kaur S, Sanches M, Villarreal V, Bowden C, Soares JC (2006) Sources of declarative memory impairment in bipolar disorder: mnemonic processes and clinical features. J Psychiatr Res 40(1):47–58CrossRefPubMed
34.
Frey BN, Andreazza AC, Nery FG, Martins MR, Quevedo J, Soares JC, Kapczinski F (2007) The role of hippocampus in the pathophysiology of bipolar disorder. Behav Pharmacol 18(5–6):419–430CrossRefPubMed
35.
Bora E, Yucel M, Pantelis C (2010) Neurocognitive markers of psychosis in bipolar disorder: a meta-analytic study. J Affect Disord 127(1–3):1–9CrossRefPubMed
36.
Glahn DC, Robinson JL, Tordesillas-Gutierrez D, Monkul ES, Holmes MK, Green MJ, Bearden CE (2010) Fronto-temporal dysregulation in asymptomatic bipolar I patients: a paired associate functional MRI study. Hum Brain Mapp 31(7):1041–1051PubMedCentralCrossRefPubMed
37.
Deckersbach T, Dougherty DD, Savage C, McMurrich S, Fischman AJ, Nierenberg A, Sachs G, Rauch SL (2006) Impaired recruitment of the dorsolateral prefrontal cortex and hippocampus during encoding in bipolar disorder. Biol Psychiatry 59(2):138–146CrossRefPubMed
38.
Eichenbaum H, Otto T, Cohen NJ (1994) Two functional components of the hippocampal memory system. Behav Brain Sci 17(03):449–472CrossRef
39.
Eichenbaum H (2004) Hippocampus: cognitive processes and neural representations that underlie declarative memory. Neuron 44(1):109–120CrossRefPubMed
40.
Ongur D, Cullen TJ, Wolf DH, Rohan M, Barreira P, Zalesak M, Heckers S (2006) The neural basis of relational memory deficits in schizophrenia. Arch Gen Psychiatry 63(4):356–365CrossRefPubMed
41.
Coleman MJ, Titone D, Krastoshevsky O, Krause V, Huang Z, Mendell NR, Eichenbaum H, Levy DL (2010) Reinforcement ambiguity and novelty do not account for transitive inference deficits in schizophrenia. Schizophr Bull 36(6):1187–1200PubMedCentralCrossRefPubMed
42.
Titone D, Ditman T, Holzman PS, Eichenbaum H, Levy DL (2004) Transitive inference in schizophrenia: impairments in relational memory organization. Schizophr Res 68(2–3):235–247CrossRefPubMed
43.
First MB, Spitzer RL, Gibbon M, Williams JBW (2002) Structured Clinical Interview for DSM-IV-TR Axis I Disorders, Research Version, Patient Edition (SCID-I/P). Biometrics Research. New York State Psychiatric Institute, New York
44.
Nelson HE (1982) National Adult Reading Test (NART): test manual. NFER-Nelson, Windsor
45.
MacCabe JH, Lambe MP, Cnattingius S, Torrang A, Bjork C, Sham PC, David AS, Murray RM, Hultman CM (2008) Scholastic achievement at age 16 and risk of schizophrenia and other psychoses: a national cohort study. Psychol Med 38(8):1133–1140. doi:10.​1017/​S003329170700204​8 CrossRefPubMed
46.
Resnick SM (1992) Matching for education in studies of schizophrenia. Arch Gen Psychiatry 49(3):246CrossRefPubMed
47.
48.
Gardner DM, Murphy AL, O’Donnell H, Centorrino F, Baldessarini RJ (2010) International consensus study of antipsychotic dosing. Am J Psychiatry 167(6):686–693CrossRefPubMed
49.
van Erp TG, Thompson PM, Kieseppa T, Bearden CE, Marino AC, Hoftman GD, Haukka J, Partonen T, Huttunen M, Kaprio J, Lonnqvist J, Poutanen VP, Toga AW, Cannon TD (2012) Hippocampal morphology in lithium and non-lithium-treated bipolar I disorder patients, non-bipolar co-twins, and control twins. Hum Brain Mapp 33(3):501–510CrossRefPubMed
50.
Koolschijn PC, van Haren NE, Cahn W, Schnack HG, Janssen J, Klumpers F, Hulshoff Pol HE, Kahn RS (2010) Hippocampal volume change in schizophrenia. J Clin Psychiatry 71(6):737–744CrossRefPubMed
51.
52.
Young RC, Biggs JT, Ziegler VE, Meyer DA (1978) A rating scale for mania: reliability, validity and sensitivity. Br J Psychiatry 133:429–435CrossRefPubMed
53.
Martinez-Aran A, Vieta E, Reinares M, Colom F, Torrent C, Sanchez-Moreno J, Benabarre A, Goikolea JM, Comes M, Salamero M (2004) Cognitive function across manic or hypomanic, depressed, and euthymic states in bipolar disorder. Am J Psychiatry 161(2):262–270CrossRefPubMed
54.
Furukawa TA, Akechi T, Azuma H, Okuyama T, Higuchi T (2007) Evidence-based guidelines for interpretation of the Hamilton Rating Scale for Depression. J Clin Psychopharmacol 27(5):531–534CrossRefPubMed
55.
Heckers S, Zalesak M, Weiss AP, Ditman T, Titone D (2004) Hippocampal activation during transitive inference in humans. Hippocampus 14(2):153–162CrossRefPubMed
56.
Pruessner JC, Li LM, Serles W, Pruessner M, Collins DL, Kabani N, Lupien S, Evans AC (2000) Volumetry of hippocampus and amygdala with high-resolution MRI and three-dimensional analysis software: minimizing the discrepancies between laboratories. Cereb Cortex 10(4):433–442CrossRefPubMed
57.
Weiss AP, DeWitt I, Goff D, Ditman T, Heckers S (2005) Anterior and posterior hippocampal volumes in schizophrenia. Schizophr Res 73(1):103–112CrossRefPubMed
58.
Pieper A, Halle M, Kikinis R (2004) 3D slicer, vol 448. In: Proceeding of IEEE international symposium on biomedical imaging: from nano to macro
59.
Jack CR Jr, Twomey CK, Zinsmeister AR, Sharbrough FW, Petersen RC, Cascino GD (1989) Anterior temporal lobes and hippocampal formations: normative volumetric measurements from MR images in young adults. Radiology 172(2):549–554PubMed
60.
Kippenhan JS, Padmanabhan A, Mervis C, Morris C, Kohn P, Koch P, Meyer-Lindenberg A, Berman KF (2008) Hippocampus-specific spatial normalization using optimized SPM parameters improves sensitivity of functional neuroimaging group analyses in Williams syndrome. Biol Psychiatry 63(7, Supplement 1):74S–75S
61.
Williams LE, Must A, Avery S, Woolard A, Woodward ND, Cohen NJ, Heckers S (2010) Eye-movement behavior reveals relational memory impairment in schizophrenia. Biol Psychiatry 68(7):617–624PubMedCentralCrossRefPubMed
62.
Armstrong K, Kose S, Williams L, Woolard A, Heckers S (2012) Impaired associative inference in patients with schizophrenia. Schizophr Bull 38(3):622–629PubMedCentralCrossRefPubMed
63.
Bora E, Fornito A, Yucel M, Pantelis C (2010) Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder. Biol Psychiatry 67(11):1097–1105CrossRefPubMed
64.
Ellison-Wright I, Bullmore E (2010) Anatomy of bipolar disorder and schizophrenia: a meta-analysis. Schizophr Res 117(1):1–12CrossRefPubMed
65.
Kempton MJ, Geddes JR, Ettinger U, Williams SC, Grasby PM (2008) Meta-analysis, database, and meta-regression of 98 structural imaging studies in bipolar disorder. Arch Gen Psychiatry 65(9):1017–1032CrossRefPubMed
66.
Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM (2009) Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. Br J Psychiatry 195(3):194–201CrossRefPubMed
67.
68.
Acuna BD, Eliassen JC, Donoghue JP, Sanes JN (2002) Frontal and parietal lobe activation during transitive inference in humans. Cereb Cortex 12(12):1312–1321CrossRefPubMed
69.
Wagner AD, Shannon BJ, Kahn I, Buckner RL (2005) Parietal lobe contributions to episodic memory retrieval. Trends Cogn Sci 9(9):445–453CrossRefPubMed
70.
Owen AM, McMillan KM, Laird AR, Bullmore E (2005) N-back working memory paradigm: a meta-analysis of normative functional neuroimaging studies. Hum Brain Mapp 25(1):46–59CrossRefPubMed
71.
Brambilla P, Glahn DC, Balestrieri M, Soares JC (2005) Magnetic resonance findings in bipolar disorder. Psychiatr Clin North Am 28(2):443–467CrossRefPubMed
72.
73.
Strakowski SM, DelBello MP, Adler CM (2005) The functional neuroanatomy of bipolar disorder: a review of neuroimaging findings. Mol Psychiatry 10(1):105–116CrossRefPubMed
74.
Kircher T, Whitney C, Krings T, Huber W, Weis S (2008) Hippocampal dysfunction during free word association in male patients with schizophrenia. Schizophr Res 101(1–3):242–255CrossRefPubMed
75.
Thompson JM, Gallagher P, Hughes JH, Watson S, Gray JM, Ferrier IN, Young AH (2005) Neurocognitive impairment in euthymic patients with bipolar affective disorder. Br J Psychiatry 186:32–40CrossRefPubMed
76.
77.
Killgore WD, Rosso IM, Gruber SA, Yurgelun-Todd DA (2009) Amygdala volume and verbal memory performance in schizophrenia and bipolar disorder. Cogn Behav Neurol 22(1):28–37CrossRefPubMed
78.
Hall J, Whalley HC, Marwick K, McKirdy J, Sussmann J, Romaniuk L, Johnstone EC, Wan HI, McIntosh AM, Lawrie SM (2010) Hippocampal function in schizophrenia and bipolar disorder. Psychol Med 40(5):761–770CrossRefPubMed
79.
Bartholomeusz CF, Proffitt TM, Savage G, Simpson L, Markulev C, Kerr M, McConchie M, McGorry PD, Pantelis C, Berger GE, Wood SJ (2011) Relational memory in first episode psychosis: implications for progressive hippocampal dysfunction after illness onset. Aust N Z J Psychiatry 45(3):206–213CrossRefPubMed
80.
Wood SJ, Proffitt T, Mahony K, Smith DJ, Buchanan JA, Brewer W, Stuart GW, Velakoulis D, McGorry PD, Pantelis C (2002) Visuospatial memory and learning in first-episode schizophreniform psychosis and established schizophrenia: a functional correlate of hippocampal pathology? Psychol Med 32(3):429–438CrossRefPubMed
81.
Achim AM, Bertrand MC, Sutton H, Montoya A, Czechowska Y, Malla AK, Joober R, Pruessner JC, Lepage M (2007) Selective abnormal modulation of hippocampal activity during memory formation in first-episode psychosis. Arch Gen Psychiatry 64(9):999–1014CrossRefPubMed
82.
Williams LE, Avery SN, Woolard AA, Heckers S (2012) Intact relational memory and normal hippocampal structure in the early stage of psychosis. Biol Psychiatry 71(2):105–113PubMedCentralCrossRefPubMed
83.
Metadata
Title
Relational memory and hippocampal function in psychotic bipolar disorder
Authors
Suzanne N. Avery
Lisa E. Williams
Austin A. Woolard
Stephan Heckers
Publication date
01-04-2014
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Psychiatry and Clinical Neuroscience / Issue 3/2014
Print ISSN: 0940-1334
Electronic ISSN: 1433-8491
DOI
https://doi.org/10.1007/s00406-013-0442-z

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