Skip to main content
Top
Published in: European Archives of Paediatric Dentistry 4/2014

01-08-2014 | Original Scientific Article

Related factors of dental caries and molar incisor hypomineralisation in a group of children with cystic fibrosis

Authors: S. Peker, S. Mete, Y. Gokdemir, B. Karadag, B. Kargul

Published in: European Archives of Paediatric Dentistry | Issue 4/2014

Login to get access

Abstract

Aim

To investigate dental caries and molar incisor hypomineralisation (MIH)-related factors such as treatment, diet, brushing and salivary factors in children with cystic fibrosis (CF) compared with healthy peers.

Study design

A cohort study was performed.

Methods

This study was performed on 30 CF children comprising patients at the Faculty of Medicine and 30 control children recruited from the Dental School. Salivary factors, dental caries, MIH, daily diet, brushing habits were analysed. Statistical analysis was calculated by SPSS for Windows.

Results

Decay missing filled teeth (DMF-T) score was 4.6 ± 4.0 in CF and 7.7 ± 2.7 in control (p = 0.001). 43 % of CF children with MIH were found to use antibiotics, but no significant difference in the caries experience was found with antibiotic usage (p > 0.05). DMF-T of CF adolescents (23 %) who use Tobramycin was 7 ± 3.5. DMF-T of CF children (20 %) who take other antibiotics was 2.5 ± 3.5, but no statistical difference was found (p = 0.054). Saliva pH, salivary flow rate, and buffering capacity were not found statistically significant (p > 0.05).

Statistics

Percentage arithmetic mean value, standard deviation, independent sample t test, Fisher’s exact test, Chi-square test and Mann–Whitney U test were used, while a p value of <0.05 was considered statistically significant.

Conclusions

Medication and diet could be considered as a risk factor for dental caries and factors such as salivary pH, good oral hygiene could play a protective role for oral health CF children. MIH frequency and lower caries experience seen in CF children could be due to salivary factors or pharmacological treatment they take. The multidisciplinary approach team would be advantageous in the management of children with CF and oral health should be under control during early years of life by paediatric dentists.
Literature
go back to reference Aps JK, Van Maele GO, Martens LC. Caries experience and oral cleanliness in cystic fibrosis homozygotes and heterozygotes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002a;93(5):560–3.PubMedCrossRef Aps JK, Van Maele GO, Martens LC. Caries experience and oral cleanliness in cystic fibrosis homozygotes and heterozygotes. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002a;93(5):560–3.PubMedCrossRef
go back to reference Aps JK, Delanghe J, Martens LC. Salivary electrolyte concentrations are associated with cystic fibrosis transmembrane regulator genotypes. Clin Chem Lab Med. 2002b;40(4):345–50.PubMedCrossRef Aps JK, Delanghe J, Martens LC. Salivary electrolyte concentrations are associated with cystic fibrosis transmembrane regulator genotypes. Clin Chem Lab Med. 2002b;40(4):345–50.PubMedCrossRef
go back to reference Aps JK, Van Maele GO, Martens LC. Oral hygiene habits and oral health in cystic fibrosis. Eur J Paediatr Dent. 2002c;3(4):181–7.PubMed Aps JK, Van Maele GO, Martens LC. Oral hygiene habits and oral health in cystic fibrosis. Eur J Paediatr Dent. 2002c;3(4):181–7.PubMed
go back to reference Arquitt CK, Boyd C, Wright JT. Cystic fibrosis transmembrane regulator gene (CFTR) is associated with abnormal enamel formation. J Dent Res. 2002;81(7):492–6.PubMedCrossRef Arquitt CK, Boyd C, Wright JT. Cystic fibrosis transmembrane regulator gene (CFTR) is associated with abnormal enamel formation. J Dent Res. 2002;81(7):492–6.PubMedCrossRef
go back to reference Atar M, Körperich EJ. Systemic disorders and their influence on the development of dental hard tissues: a literature review. J Dent. 2010;38:296–306.PubMedCrossRef Atar M, Körperich EJ. Systemic disorders and their influence on the development of dental hard tissues: a literature review. J Dent. 2010;38:296–306.PubMedCrossRef
go back to reference Azevedo TD, Feijó GC, Bezerra AC. Presence of developmental defects of enamel in cystic fibrosis patients. J Dent Child. 2006;73(3):159–63. Azevedo TD, Feijó GC, Bezerra AC. Presence of developmental defects of enamel in cystic fibrosis patients. J Dent Child. 2006;73(3):159–63.
go back to reference Bals R, Hubert D, Tummler B. Antibiotic treatment of CF lung disease: from bench to bedside. J Cyst Fibros. 2011;10:146–51.CrossRef Bals R, Hubert D, Tummler B. Antibiotic treatment of CF lung disease: from bench to bedside. J Cyst Fibros. 2011;10:146–51.CrossRef
go back to reference Chi DL. Dental caries prevalence in children and adolescents with cystic fibrosis: a qualitative systematic review and recommendations for future research. Int J Paediatr Dent. 2013;23(5):376–86. doi:10.1111/ipd.12042.PubMedCrossRef Chi DL. Dental caries prevalence in children and adolescents with cystic fibrosis: a qualitative systematic review and recommendations for future research. Int J Paediatr Dent. 2013;23(5):376–86. doi:10.​1111/​ipd.​12042.PubMedCrossRef
go back to reference Costa-Silva CM, Jeremias F, Souza JF, et al. Molar-incisor hypomineralisation: prevalence, severity and clinical consequences among Brazilian children. Int J Paediatr Dent. 2010;20:426–34.PubMedCrossRef Costa-Silva CM, Jeremias F, Souza JF, et al. Molar-incisor hypomineralisation: prevalence, severity and clinical consequences among Brazilian children. Int J Paediatr Dent. 2010;20:426–34.PubMedCrossRef
go back to reference Costa-Silva CM, Ambrosano GMB, Jeremias F, Souza JF, Mialhe FL. Increase in severity of molar-incisor hypomineralisation and its relationship with colour of enamel opacity: a prospective cohort study. Int J Paediatr Dent. 2011;21:333–41.PubMedCrossRef Costa-Silva CM, Ambrosano GMB, Jeremias F, Souza JF, Mialhe FL. Increase in severity of molar-incisor hypomineralisation and its relationship with colour of enamel opacity: a prospective cohort study. Int J Paediatr Dent. 2011;21:333–41.PubMedCrossRef
go back to reference Dabrowska E, Błahuszewska K, Minarowska A. Assessment of dental status and oral hygiene in the study population of cystic fibrosis patients in the Podlasie province. Adv Med Sci. 2006;51(1):100–3.PubMed Dabrowska E, Błahuszewska K, Minarowska A. Assessment of dental status and oral hygiene in the study population of cystic fibrosis patients in the Podlasie province. Adv Med Sci. 2006;51(1):100–3.PubMed
go back to reference Davies H, Bagg J, Muxworthy S, Goodchild MC, McPherson MA. Electrolyte concentrations in control and cystic fibrosis submandibular saliva. Biochem Soc Trans. 1990;18(3):447–8.PubMed Davies H, Bagg J, Muxworthy S, Goodchild MC, McPherson MA. Electrolyte concentrations in control and cystic fibrosis submandibular saliva. Biochem Soc Trans. 1990;18(3):447–8.PubMed
go back to reference Edgar WM, Bowen WH, Cole MF. Development of rampant dental caries, and composition of plaque fluid and saliva in irradiated primates. J Oral Pathol. 1981;10:284–95.PubMedCrossRef Edgar WM, Bowen WH, Cole MF. Development of rampant dental caries, and composition of plaque fluid and saliva in irradiated primates. J Oral Pathol. 1981;10:284–95.PubMedCrossRef
go back to reference Fernald GW, Roberts MW, Boat TF. Cystic fibrosis: a current review. Pediatr Dent. 1990;12(2):72–8.PubMed Fernald GW, Roberts MW, Boat TF. Cystic fibrosis: a current review. Pediatr Dent. 1990;12(2):72–8.PubMed
go back to reference Ferrazzano GF, Orlando S, Sangianantoni G. Dental and periodontal health status in children affected by cystic fibrosis in a southern Italian region. Eur J Paediatr Dent. 2009;10(2):65–8.PubMed Ferrazzano GF, Orlando S, Sangianantoni G. Dental and periodontal health status in children affected by cystic fibrosis in a southern Italian region. Eur J Paediatr Dent. 2009;10(2):65–8.PubMed
go back to reference Ferrazzano GF, Sangianantoni G, Cantile T, et al. Dental enamel defects in Italian children with cystic fibrosis: an observational study. Community Dent Health. 2012;29(1):106–9.PubMed Ferrazzano GF, Sangianantoni G, Cantile T, et al. Dental enamel defects in Italian children with cystic fibrosis: an observational study. Community Dent Health. 2012;29(1):106–9.PubMed
go back to reference Gawenis LR, Spencer P, Hillman LS, et al. Mineral content of calcified tissues in cystic fibrosis mice. Biol Trace Elem Res. 2001;83:69–81.PubMedCrossRef Gawenis LR, Spencer P, Hillman LS, et al. Mineral content of calcified tissues in cystic fibrosis mice. Biol Trace Elem Res. 2001;83:69–81.PubMedCrossRef
go back to reference Ghanim A, Marino R, Morgan M, Bailey D, Manton D. An in vivo investigation of salivary properties, enamel hypomineralisation, and carious lesion severity in a group of Iraqi schoolchildren. Int J Paediatr Dent. 2013;23:2–12.PubMedCrossRef Ghanim A, Marino R, Morgan M, Bailey D, Manton D. An in vivo investigation of salivary properties, enamel hypomineralisation, and carious lesion severity in a group of Iraqi schoolchildren. Int J Paediatr Dent. 2013;23:2–12.PubMedCrossRef
go back to reference Jagels A, Sweeney EA. Oral health of patients with cystic fibrosis and their siblings. J Dent Res. 1975;55:991–5.CrossRef Jagels A, Sweeney EA. Oral health of patients with cystic fibrosis and their siblings. J Dent Res. 1975;55:991–5.CrossRef
go back to reference Jasulaityte L, Veerkamp JS, Weerheijm KL. Molar-incisor-hypomineralisation: review and prevalence data from a study of primary school children in Kaunas (Lithuania). Eur Arch Paediatr Dent. 2007;8(2):87–94.PubMedCrossRef Jasulaityte L, Veerkamp JS, Weerheijm KL. Molar-incisor-hypomineralisation: review and prevalence data from a study of primary school children in Kaunas (Lithuania). Eur Arch Paediatr Dent. 2007;8(2):87–94.PubMedCrossRef
go back to reference Kargul B, Tanboga I, Ergeneli S, Karakoc F, Dagli E. Inhaler medicament effects on saliva and plaque pH in asthmatic children. J Clin Pediatr Dent. 1998;22(2):137–40.PubMed Kargul B, Tanboga I, Ergeneli S, Karakoc F, Dagli E. Inhaler medicament effects on saliva and plaque pH in asthmatic children. J Clin Pediatr Dent. 1998;22(2):137–40.PubMed
go back to reference Kinirons MJ. Increased salivary buffering in association with a low caries experience in children suffering from cystic fibrosis. J Dent Res. 1983;62:815–7.PubMedCrossRef Kinirons MJ. Increased salivary buffering in association with a low caries experience in children suffering from cystic fibrosis. J Dent Res. 1983;62:815–7.PubMedCrossRef
go back to reference Kinirons MJ. Dental health of patients suffering from cystic fibrosis in northern Ireland. Community Dent Health. 1989;6:113–20.PubMed Kinirons MJ. Dental health of patients suffering from cystic fibrosis in northern Ireland. Community Dent Health. 1989;6:113–20.PubMed
go back to reference Kinirons MJ. The effects of antibiotic therapy on the oral health of cystic fibrosis children. Int J Paediatr Dent. 1992;2:139–43.PubMedCrossRef Kinirons MJ. The effects of antibiotic therapy on the oral health of cystic fibrosis children. Int J Paediatr Dent. 1992;2:139–43.PubMedCrossRef
go back to reference Kuscu OO, Sandalli N, Dikmen S, et al. Association of amoxicillin use and molar incisor hypomineralisation in piglets: visual and mineral density evaluation. Arch Oral Biol. 2013;58:1422–33.PubMedCrossRef Kuscu OO, Sandalli N, Dikmen S, et al. Association of amoxicillin use and molar incisor hypomineralisation in piglets: visual and mineral density evaluation. Arch Oral Biol. 2013;58:1422–33.PubMedCrossRef
go back to reference Littleton NW, White CL. Dental findings from a preliminary study of children receiving extended antibiotic therapy. J Am Dent Assoc. 1964;68:520–5.PubMed Littleton NW, White CL. Dental findings from a preliminary study of children receiving extended antibiotic therapy. J Am Dent Assoc. 1964;68:520–5.PubMed
go back to reference Lygidakis NA, Dimou G, Marinou D. Molar-incisor-hypomineralisation (MIH). A retrospective clinical study in Greek children. II. Possible medical aetiological factors. Eur Arch Paediatr Dent. 2008;9(4):207–17.PubMedCrossRef Lygidakis NA, Dimou G, Marinou D. Molar-incisor-hypomineralisation (MIH). A retrospective clinical study in Greek children. II. Possible medical aetiological factors. Eur Arch Paediatr Dent. 2008;9(4):207–17.PubMedCrossRef
go back to reference Martens LC, Aps JKM, Van Maele GOG. Is oral health at risk in people with cystic fibrosis? Eur J Paediatr Dent. 2001;2:21–7. Martens LC, Aps JKM, Van Maele GOG. Is oral health at risk in people with cystic fibrosis? Eur J Paediatr Dent. 2001;2:21–7.
go back to reference Narang A, Maguire A, Nunn JH, Bush A. Oral health and related factors in cystic fibrosis and other chronic respiratory disorders. Arch Dis Child. 2003;88:702–7.PubMedCentralPubMedCrossRef Narang A, Maguire A, Nunn JH, Bush A. Oral health and related factors in cystic fibrosis and other chronic respiratory disorders. Arch Dis Child. 2003;88:702–7.PubMedCentralPubMedCrossRef
go back to reference Rosenstein BJ, Cutting GR. For the cystic fibrosis foundation consensus panel. The diagnosis of cystic fibrosis: a consensus statement. J Pediatr. 1998;132:589–95.PubMedCrossRef Rosenstein BJ, Cutting GR. For the cystic fibrosis foundation consensus panel. The diagnosis of cystic fibrosis: a consensus statement. J Pediatr. 1998;132:589–95.PubMedCrossRef
go back to reference Schwiebert LM, Estell K, Propst SM. Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression. Am J Physiol. 1999;276:700–10. Schwiebert LM, Estell K, Propst SM. Chemokine expression in CF epithelia: implications for the role of CFTR in RANTES expression. Am J Physiol. 1999;276:700–10.
go back to reference Sui W, Boyd C, Wright JT. Altered pH regulation during enamel development in the cystic fibrosis mouse incisor. J Dent Res. 2003;82:388–92.PubMedCrossRef Sui W, Boyd C, Wright JT. Altered pH regulation during enamel development in the cystic fibrosis mouse incisor. J Dent Res. 2003;82:388–92.PubMedCrossRef
go back to reference van Westreenen M, Tiddens HA. New antimicrobial strategies in cystic fibrosis. Paediatr Drugs. 2010;12:343–52.PubMedCrossRef van Westreenen M, Tiddens HA. New antimicrobial strategies in cystic fibrosis. Paediatr Drugs. 2010;12:343–52.PubMedCrossRef
go back to reference Weerheijm KL. Molar ıncisor hypomineralisation (MIH). Eur J Paediatr Dent. 2003;4:115–20. Weerheijm KL. Molar ıncisor hypomineralisation (MIH). Eur J Paediatr Dent. 2003;4:115–20.
go back to reference Welsh MJ, Ramsey BW, Accurso FJ, Cutting GR. Cystic fibrosis. In: Scriver CF, Beaudet AL, Sly WS, editors. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill; 2001. p. 5122–88. Welsh MJ, Ramsey BW, Accurso FJ, Cutting GR. Cystic fibrosis. In: Scriver CF, Beaudet AL, Sly WS, editors. The metabolic and molecular bases of inherited disease. New York: McGraw-Hill; 2001. p. 5122–88.
go back to reference Whatling R, Fearne JM. Molar incisor hypomineralisation: a study of aetiological factors in a group of UK children. Int J Paediatr Dent. 2008;18(3):155–62.PubMedCrossRef Whatling R, Fearne JM. Molar incisor hypomineralisation: a study of aetiological factors in a group of UK children. Int J Paediatr Dent. 2008;18(3):155–62.PubMedCrossRef
go back to reference William V, Messer LB, Burrow MF. Molar incisor hypomineralisation: review and recommendations for clinical management. Pediatr Dent. 2006;28(3):224–32.PubMed William V, Messer LB, Burrow MF. Molar incisor hypomineralisation: review and recommendations for clinical management. Pediatr Dent. 2006;28(3):224–32.PubMed
go back to reference Willmott NS, Bryan RAE, Duggal MS. Molar-incisor-hypomineralisation: a literature review. Eur Arch Paediatr Dent. 2008;9(4):172–9.PubMedCrossRef Willmott NS, Bryan RAE, Duggal MS. Molar-incisor-hypomineralisation: a literature review. Eur Arch Paediatr Dent. 2008;9(4):172–9.PubMedCrossRef
Metadata
Title
Related factors of dental caries and molar incisor hypomineralisation in a group of children with cystic fibrosis
Authors
S. Peker
S. Mete
Y. Gokdemir
B. Karadag
B. Kargul
Publication date
01-08-2014
Publisher
Springer Berlin Heidelberg
Published in
European Archives of Paediatric Dentistry / Issue 4/2014
Print ISSN: 1818-6300
Electronic ISSN: 1996-9805
DOI
https://doi.org/10.1007/s40368-014-0112-5

Other articles of this Issue 4/2014

European Archives of Paediatric Dentistry 4/2014 Go to the issue