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BMC Neurology
Published in: BMC Neurology 1/2012

Open Access 01-12-2012 | Research article

Regulatory role of vitamin D in T-cell reactivity against myelin peptides in relapsing-remitting multiple sclerosis patients

Authors: Laia Grau-López, Maria Luisa Granada, Dàlia Raïch-Regué, Mar Naranjo-Gómez, Francesc E Borràs-Serres, Eva Martínez-Cáceres, Cristina Ramo-Tello

Published in: BMC Neurology | Issue 1/2012

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Abstract

Background

Low levels of plasma 25-hydroxyvitaminD (25(OH)D) are associated with a higher incidence of multiple sclerosis (MS) due to the immune suppressive properties of vitamin D.
The aim of this study was to determine the correlation between plasma 25(OH)D concentrations and clinical and immunological variables in a cohort of multiple sclerosis patients.

Methods

Plasma 25(OH)D concentrations were evaluated in summer and winter in 15 primary progressive MS (PPMS) patients, 40 relapsing- remitting MS (RRMS) patients and 40 controls (HC). Protocol variables included demographic and clinical data, radiological findings and immunological variables (oligoclonal bands, HLADR15 and T-lymphocyte proliferation to a definite mix of 7 myelin peptides).

Results

During the winter, plasma concentrations were significantly lower in RRMS patients compared to HC, whereas no differences were found in summer. No relationships were found between plasma 25(OH)D concentrations and clinical or radiological variables. RRMS patients with a positive T-cell proliferation to a mix of myelin peptides (n = 31) had lower 25(OH)D concentrations.

Conclusions

25(OH)D is an immunomodulatory molecule that might have a regulatory role in T-cell proliferation to myelin peptides in RRMS patients.
Appendix
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Literature
1.
Compston A, Confavreux C, Lassmann H, McDonald I, Miller D, Noseworthy J, et al: McAlpine’s Multiple Sclerosis. 2006, Philadelphia: Churchill Livingstone Elsevier, Inc, 982-
2.
Brown SJ: The role of Vitamin D in multiple sclerosis. Ann Pharmacother. 2006, 40: 1158-1161. 10.1345/aph.1G513.CrossRefPubMed
3.
VanAmerongen BM, Dijkstra CD, Lips P, Polman CH: Multiple sclerosis and vitamin D: an update. Eur J Clin Nutr. 2004, 58: 1095-1109. 10.1038/sj.ejcn.1601952.CrossRefPubMed
4.
Correale J, Ysrraelit MC, Gaitan MI: Immunomodulatory effects of Vitamin D in multiple sclerosis. Brain. 2009, 132: 1146-1160. 10.1093/brain/awp033.CrossRefPubMed
5.
Decallonne B, van Etten E, Overbergh L, Valckx D, Bouillon R, Mathieu C: 1Alpha,25-dihydroxyvitamin D3 restores thymocyte apoptosis sensitivity in non-obese diabetic (NOD) mice through dendritic cells. J Autoimmun. 2005, 24: 281-289. 10.1016/j.jaut.2005.03.007.CrossRefPubMed
6.
Raïch-Regué D, Grau-López L, Naranjo-Gómez M, Ramo-Tello C, Pujol-Borrell R, Martínez-Cáceres EM, Borrás FE: Stable antigen-specific T-cell hyporesponsiveness induced by tolerogenic dendritic cells from multiple sclerosis patients. Eur J Immunol. 2012, 42: 771-782. 10.1002/eji.201141835.CrossRef
7.
Munger KL, Levin L, Hollis BW, Howard NS, Ascherio A: Serum 25-hydroxyvitamin D levels and risk of multiple sclerosis. J Am Med Assoc. 2006, 296: 2832-2838. 10.1001/jama.296.23.2832.CrossRef
8.
Smolders J, Menheere P, Kessels A, Damoiseaux J, Hupperts R: Association of vitamin D metabolite levels with relapse rate and disability in multiple sclerosis. Mult Scler. 2008, 14: 1220-1224. 10.1177/1352458508094399.CrossRefPubMed
9.
Simpson S, Taylor B, Blizzard L, Ponsonby AL, Pittas F, Tremlett H, Dwyer T, Gies P, Van Der Mei I: Higher 25-hydroxyvitamin D is associated with lower relapse risk in multiple sclerosis. Ann Neurol. 2010, 68: 193-203.PubMed
10.
Mowry EM, Krupp LB, Milazzo M, Chabas D, Strober JB, Belman AL, McDonald JC, Oksenberg JR, Bacchetti P, Waubant E: Vitamin D status is associated with relapse rate in pediatric-onset multiple sclerosis. Ann Neurol. 2010, 67: 618-624.PubMed
11.
Smolders J, Thewissen M, Peelen E, Menheere P, Tervaert JW, Damoiseaux J, Hupperts R: Vitamin D status is positively correlated with regulatory T cell function in patients with multiple sclerosis. PLoS One. 2009, 13: 6635-CrossRef
12.
Burton JM, Kimball S, Vieth R, Bar-Or A, Dosch HM, Cheung R, et al: A phase I/II dose-escalation trial of vitamin D3 and calcium in multiple sclerosis. Neurology. 2010, 74: 1852-1859. 10.1212/WNL.0b013e3181e1cec2.CrossRefPubMedPubMedCentral
13.
McDonald WI, Compston A, Edan G, Goodkin D, Hartung HP, Lublin FD, et al: Recommended diagnostic criteria for multiple sclerosis: guidelines from the International Panel on the diagnosis of multiple sclerosis. Ann Neurol. 2001, 50: 121-127. 10.1002/ana.1032.CrossRefPubMed
14.
Kurtzke JF: Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS). Neurology. 1983, 33: 1444-1452. 10.1212/WNL.33.11.1444.CrossRefPubMed
15.
Grau-López L, Raïch D, Ramo-Tello C, Naranjo-Gómez M, Pujol-Borrell R, Borràs FE, Martínez-Cáceres E: Myelin peptides in multiple sclerosis. Autoimmun Rev. 2009, 8: 650-653. 10.1016/j.autrev.2009.02.013.CrossRefPubMed
16.
17.
Dawson-Hughes B, Heaney RP, Holick MF, Lips P, Meunier PJ, Vieth R: Estimates of optimal vitamin D status. Osteoporos Int. 2005, 16: 713-716. 10.1007/s00198-005-1867-7.CrossRefPubMed
18.
Soilu-Hanninen M, Arias L, Mononen I, Heikkilä A, Viljanen M, Hänninen A: 25-Hydroxyvitamin D levels in serum at the onset of multiple sclerosis. Mult Scler. 2005, 11: 266-271. 10.1191/1352458505ms1157oa.CrossRefPubMed
19.
Lucchinetti C, Bruck W, Parisi J, Scheithauer B, Rodriguez M, Lassmann H: Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination. Ann Neurol. 2000, 47: 707-717. 10.1002/1531-8249(200006)47:6<707::AID-ANA3>3.0.CO;2-Q.CrossRefPubMed
20.
Smolders J, Damoiseaux J, Menheere P, Hupperts R: Vitamin D as an immune modulator in multiple sclerosis, a review. J Neuroimmunol. 2008, 194: 7-17. 10.1016/j.jneuroim.2007.11.014.CrossRefPubMed
21.
Grau-López L, Raïch D, Ramo-Tello C, Naranjo-Gómez M, Dávalos A, Pujol-Borrell R, et al: Specific T-cell proliferation to myelin peptides in relapsing-remitting multiple sclerosis. Eur J Neurol. 2011, 18 (8): 1101-1104. 10.1111/j.1468-1331.2010.03307.x.CrossRefPubMed
22.
Pedersen LB, Nashold FE, Spach KM, Hayes CE: 1,25-dihydroxyvitamin D3 reverses experimental autoimmune encephalomyelitis by inhibiting chemokine synthesis and monocyte trafficking. J Neurosci Res. 2007, 85: 2480-2490. 10.1002/jnr.21382.CrossRefPubMed
23.
Smolders J, Peelen E, Thewissen M, Menheere P, Cohen Tervaert JW, Hupperts R, Damoiseaux J: The relevance of vitamin D receptor gene polymorphisms for vitamin D research in multiple sclerosis. Autoimmun Rev. 2009, 8: 621-626. 10.1016/j.autrev.2009.02.009.CrossRefPubMed
24.
Dickinson JL, Perera DI, van der Mei AF, Ponsonby AL, Polanowski AM, Thomson RJ, Taylor BV, McKay JD, Stankovich J, Dwyer T: Past environmental sun exposure and risk of multiple sclerosis: a role for the Cdx-2 Vitamin D receptor variant in this interaction. Mult Scler. 2009, 15: 563-570. 10.1177/1352458509102459.CrossRefPubMed
Metadata
Title
Regulatory role of vitamin D in T-cell reactivity against myelin peptides in relapsing-remitting multiple sclerosis patients
Authors
Laia Grau-López
Maria Luisa Granada
Dàlia Raïch-Regué
Mar Naranjo-Gómez
Francesc E Borràs-Serres
Eva Martínez-Cáceres
Cristina Ramo-Tello
Publication date
01-12-2012
Publisher
BioMed Central
Published in
BMC Neurology / Issue 1/2012
Electronic ISSN: 1471-2377
DOI
https://doi.org/10.1186/1471-2377-12-103

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