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Open Access 01-12-2003 | Review

Regulation of intraluteal production of prostaglandins

Authors: Milo C Wiltbank, Joseph S Ottobre

Published in: Reproductive Biology and Endocrinology | Issue 1/2003

Abstract

There is clear evidence for intraluteal production of prostaglandins (PGs) in numerous species and under a variety of experimental conditions. In general, secretion of PGs appears to be elevated in the early corpus luteum (CL) and during the period of luteolysis. Regulation of intraluteal PG production is regulated by a variety of factors. An autoamplification pathway in which PGF-2alpha stimulates intraluteal production of PGF-2alpha has been identified in a number of species. The mechanisms underlying this autoamplification pathway appear to differ by species with expression of Cyclooxygenase-2 (Cox-2) and activity of phospholipase A2 acting as important physiological control points. In addition, a number of other responses that are induced by PGF-2alpha (decreased luteal progesterone, increased endothelin-1, increased cytokines) also have been found to increase intraluteal PGF-2alpha production. Thus, regulation of intraluteal PG production may serve to initiate or amplify physiological signals to the CL and may be important in specific aspects of luteal physiology particularly during luteal regression.

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Title: Regulation of intraluteal production of prostaglandins
Authors: Milo C Wiltbank
Joseph S Ottobre
Publication date: 01-12-2003
Publisher: BioMed Central
Published in: Reproductive Biology and Endocrinology / Issue 1/2003
Electronic ISSN: 1477-7827
DOI: https://doi.org/10.1186/1477-7827-1-91

Keynote webinar | Spotlight on medication adherence

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Regulation of intraluteal production of prostaglandins

Abstract

Keynote webinar | Spotlight on medication adherence

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Abstract

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