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BMC Public Health
Published in: BMC Public Health 1/2002

Open Access 01-12-2002 | Research article

Regular use of aspirin and pancreatic cancer risk

Authors: Ravi J Menezes, Kenneth R Huber, Martin C Mahoney, Kirsten B Moysich

Published in: BMC Public Health | Issue 1/2002

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Abstract

Background

Regular use of aspirin and other non-steroidal anti-inflammatory drugs (NSAIDs) has been consistently associated with reduced risk of colorectal cancer and adenoma, and there is some evidence for a protective effect for other types of cancer. As experimental studies reveal a possible role for NSAIDs is reducing the risk of pancreatic cancer, epidemiological studies examining similar associations in human populations become more important.

Methods

In this hospital-based case-control study, 194 patients with pancreatic cancer were compared to 582 age and sex-matched patients with non-neoplastic conditions to examine the association between aspirin use and risk of pancreatic cancer. All participants received medical services at the Roswell Park Cancer Institute in Buffalo, NY and completed a comprehensive epidemiologic questionnaire that included information on demographics, lifestyle factors and medical history as well as frequency and duration of aspirin use. Patients using at least one tablet per week for at least six months were classified as regular aspirin users. Unconditional logistic regression was used to compute crude and adjusted odds ratios (ORs) with 95% confidence intervals (CIs).

Results

Pancreatic cancer risk in aspirin users was not changed relative to non-users (adjusted OR = 1.00; 95% CI 0.72–1.39). No significant change in risk was found in relation to greater frequency or prolonged duration of use, in the total sample or in either gender.

Conclusions

These data suggest that regular aspirin use may not be associated with lower risk of pancreatic cancer.
Literature
1.
Marnett LJ: Aspirin and related nonsteroidal anti-inflammatory drugs as chemopreventive agents against colon cancer. Prev Med. 1995, 24: 103-6. 10.1006/pmed.1995.1017.CrossRefPubMed
2.
3.
Rosenberg L, Louik C, Shapiro S: Nonsteroidal antiinflammatory drug use and reduced risk of large bowel carcinoma. Cancer. 1998, 82: 2326-33. 10.1002/(SICI)1097-0142(19980615)82:12<2326::AID-CNCR5>3.0.CO;2-Q.CrossRefPubMed
4.
Collet JP, Sharpe C, Belzile E, Boivin JF, Hanley J, Abenhaim L: Colorectal cancer prevention by non-steroidal anti-inflammatory drugs: effects of dosage and timing. Br J Cancer. 1999, 81: 62-8. 10.1038/sj.bjc.6690651.CrossRefPubMedPubMedCentral
5.
Schreinemachers DM, Everson RB: Aspirin use and lung, colon, and breast cancer incidence in a prospective study. Epidemiology. 1994, 5: 138-46.CrossRefPubMed
6.
Funkhouser EM, Sharp GB: Aspirin and reduced risk of esophageal carcinoma. Cancer. 1995, 76: 1116-9.CrossRefPubMed
7.
Harris RE, Namboodiri KK, Farrar WB: Nonsteroidal antiinflammatory drugs and breast cancer. Epidemiology. 1996, 7: 203-5.CrossRefPubMed
8.
Coogan PF, Rao SR, Rosenberg L, Palmer JR, Strom BL, Zauber AG, Stolley PD, Shapiro S: The relationship of nonsteroidal anti-inflammatory drug use to the risk of breast cancer. Prev Med. 1999, 29: 72-6. 10.1006/pmed.1999.0518.CrossRefPubMed
9.
Zaridze D, Borisova E, Maximovitch D, Chkhikvadze V: Aspirin protects against gastric cancer: results of a case-control study from Moscow, Russia. Int J Cancer. 1999, 82: 473-6. 10.1002/(SICI)1097-0215(19990812)82:4<473::AID-IJC1>3.0.CO;2-K.CrossRefPubMed
10.
Thun MJ, Henley SJ, Patrono C: Nonsteroidal anti-inflammatory drugs as anticancer agents: mechanistic, pharmacologic, and clinical issues. J Natl Cancer Inst. 2002, 94: 252-66. 10.1093/jnci/94.4.252.CrossRefPubMed
11.
Ahnen DJ: Colon cancer prevention by NSAIDs: what is the mechanism of action?. Eur J Surg Suppl. 1998, 111-4. 10.1080/11024159850191544.
12.
Gupta RA, DuBois RN: Aspirin, NSAIDS, and colon cancer prevention: mechanisms?. Gastroenterology. 1998, 114: 1095-8.CrossRefPubMed
13.
Shiff SJ, Rigas B: The role of cyclooxygenase inhibition in the antineoplastic effects of nonsteroidal antiinflammatory drugs (NSAIDs). J Exp Med. 1999, 190: 445-50. 10.1084/jem.190.4.445.CrossRefPubMedPubMedCentral
14.
Molina MA, Sitja-Arnau M, Lemoine MG, Frazier ML, Sinicrope FA: Increased cyclooxygenase-2 expression in human pancreatic carcinomas and cell lines: growth inhibition by nonsteroidal anti-inflammatory drugs. Cancer Res. 1999, 59: 4356-62.PubMed
15.
Okami J, Yamamoto H, Fujiwara Y, Tsujie M, Kondo M, Noura S, Oshima S, Nagano H, Dono K, Umeshita K, Ishikawa O, Sakon M, Matsuura N, Nakamori S, Monden M: Overexpression of cyclooxygenase-2 in carcinoma of the pancreas. Clin Cancer Res. 1999, 5: 2018-24.PubMed
16.
Tucker ON, Dannenberg AJ, Yang EK, Zhang F, Teng L, Daly JM, Soslow RA, Masferrer JL, Woerner BM, Koki AT, Fahey TJ: Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer. Cancer Res. 1999, 59: 987-90.PubMed
17.
Koshiba T, Hosotani R, Miyamoto Y, Wada M, Lee JU, Fujimoto K, Tsuji S, Nakajima S, Doi R, Imamura M: Immunohistochemical analysis of cyclooxygenase-2 expression in pancreatic tumors. Int J Pancreatol. 1999, 26: 69-76. 10.1159/000063508.CrossRefPubMed
18.
Yip-Schneider MT, Barnard DS, Billings SD, Cheng L, Heilman DK, Lin A, Marshall SJ, Crowell PL, Marshall MS, Sweeney CJ: Cyclooxygenase-2 expression in human pancreatic adenocarcinomas. Carcinogenesis. 2000, 21: 139-46. 10.1093/carcin/21.2.139.CrossRefPubMed
19.
van Rees BP, Ristimaki A: Cyclooxygenase-2 in carcinogenesis of the gastrointestinal tract. Scand J Gastroenterol. 2001, 36: 897-903. 10.1080/003655201750305387.CrossRefPubMed
20.
Takahashi M, Furukawa F, Toyoda K, Sato H, Hasegawa R, Imaida K, Hayashi Y: Effects of various prostaglandin synthesis inhibitors on pancreatic carcinogenesis in hamsters after initiation with N-nitrosobis(2-oxopropyl)amine. Carcinogenesis. 1990, 11: 393-5.CrossRefPubMed
21.
Perugini RA, McDade TP, Vittimberga FJ, Duffy AJ, Callery MP: Sodium salicylate inhibits proliferation and induces G1 cell cycle arrest in human pancreatic cancer cell lines. J Gastrointest Surg. 2000, 4: 24-32. 10.1016/S1091-255X(00)80029-3.CrossRefPubMed
22.
Kokawa A, Kondo H, Gotoda T, Ono H, Saito D, Nakadaira S, Kosuge T, Yoshida S: Increased expression of cyclooxygenase-2 in human pancreatic neoplasms and potential for chemoprevention by cyclooxygenase inhibitors. Cancer. 2001, 91: 333-8. 10.1002/1097-0142(20010115)91:2<333::AID-CNCR1006>3.0.CO;2-N.CrossRefPubMed
23.
Subbaramaiah K, Telang N, Ramonetti JT, Araki R, DeVito B, Weksler BB, Dannenberg AJ: Transcription of cyclooxygenase-2 is enhanced in transformed mammary epithelial cells. Cancer Res. 1996, 56: 4424-9.PubMed
24.
Heasley LE, Thaler S, Nicks M, Price B, Skorecki K, Nemenoff RA: Induction of cytosolic phospholipase A2 by oncogenic Ras in human non-small cell lung cancer. J Biol Chem. 1997, 272: 14501-4. 10.1074/jbc.272.23.14501.CrossRefPubMed
25.
Almoguera C, Shibata D, Forrester K, Martin J, Arnheim N, Perucho M: Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell. 1988, 53: 549-54.CrossRefPubMed
26.
Merati K, said Siadaty M, Andea A, Sarkar F, Ben-Josef E, Mohammad R, Philip P, Shields AF, Vaitkevicius V, Grignon DJ, Adsay NV: Expression of inflammatory modulator COX-2 in pancreatic ductal adenocarcinoma and its relationship to pathologic and clinical parameters. Am J Clin Oncol. 2001, 24: 447-52. 10.1097/00000421-200110000-00007.CrossRefPubMed
27.
Gridley G, McLaughlin JK, Ekbom A, Klareskog L, Adami HO, Hacker DG, Hoover R, Fraumeni JF: Incidence of cancer among patients with rheumatoid arthritis. J Natl Cancer Inst. 1993, 85: 307-11.CrossRefPubMed
28.
Coogan PF, Rosenberg L, Palmer JR, Strom BL, Zauber AG, Stolley PD, Shapiro S: Nonsteroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel. Cancer Epidemiol Biomarkers Prev. 2000, 9: 119-23.PubMed
29.
Langman MJ, Cheng KK, Gilman EA, Lancashire RJ: Effect of anti-inflammatory drugs on overall risk of common cancer: case-control study in general practice research database. Bmj. 2000, 320: 1642-6. 10.1136/bmj.320.7250.1642.CrossRefPubMedPubMedCentral
30.
Anderson KE, Johnson TW, Lazovich D, Folsom AR: Association Between Nonsteroidal Anti-Inflammatory Drug Use and the Incidence of Pancreatic Cancer. J Natl Cancer Inst. 2002, 94: 1168-1171. 10.1093/jnci/94.15.1168.CrossRefPubMed
31.
Mettlin C: Milk drinking, other beverage habits, and lung cancer risk. Int J Cancer. 1989, 43: 608-12.CrossRefPubMed
32.
Mettlin C, Croghan I, Natarajan N, Lane W: The association of age and familial risk in a case-control study of breast cancer. Am J Epidemiol. 1990, 131: 973-83.PubMed
33.
Mettlin C, Natarajan N, Huben R: Vasectomy and prostate cancer risk. Am J Epidemiol. 1990, 132: 1056-61.PubMed
34.
Suh O, Mettlin C, Petrelli NJ: Aspirin use, cancer, and polyps of the large bowel. Cancer. 1993, 72: 1171-7.CrossRefPubMed
35.
Cornelison TL, Natarajan N, Piver MS, Mettlin CJ: Tubal ligation and the risk of ovarian carcinoma. Cancer Detect Prev. 1997, 21: 1-6.PubMed
36.
Anderson KE, Potter JD, Mack T: Pancreas. In: Cancer epidemiology and prevention. Edited by: Schottenfeld D, Fraumeni Jr JF. 1996, New York (NY): Oxford University Press, 725-71. 2
37.
Marnett LJ, DuBois RN: COX-2: a target for colon cancer prevention. Annu Rev Pharmacol Toxicol. 2002, 42: 55-80. 10.1146/annurev.pharmtox.42.082301.164620.CrossRefPubMed
Metadata
Title
Regular use of aspirin and pancreatic cancer risk
Authors
Ravi J Menezes
Kenneth R Huber
Martin C Mahoney
Kirsten B Moysich
Publication date
01-12-2002
Publisher
BioMed Central
Published in
BMC Public Health / Issue 1/2002
Electronic ISSN: 1471-2458
DOI
https://doi.org/10.1186/1471-2458-2-18

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