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Radiation Oncology

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Open Access 01-12-2011 | Research

Registration accuracy for MR images of the prostate using a subvolume based registration protocol

Authors: Joakim H Jonsson, Patrik Brynolfsson, Anders Garpebring, Mikael Karlsson, Karin Söderström, Tufve Nyholm

Published in: Radiation Oncology | Issue 1/2011

Abstract

Background

In recent years, there has been a considerable research effort concerning the integration of magnetic resonance imaging (MRI) into the external radiotherapy workflow motivated by the superior soft tissue contrast as compared to computed tomography. Image registration is a necessary step in many applications, e.g. in patient positioning and therapy response assessment with repeated imaging. In this study, we investigate the dependence between the registration accuracy and the size of the registration volume for a subvolume based rigid registration protocol for MR images of the prostate.

Methods

Ten patients were imaged four times each over the course of radiotherapy treatment using a T2 weighted sequence. The images were registered to each other using a mean square distance metric and a step gradient optimizer for registration volumes of different sizes. The precision of the registrations was evaluated using the center of mass distance between the manually defined prostates in the registered images. The optimal size of the registration volume was determined by minimizing the standard deviation of these distances.

Results

We found that prostate position was most uncertain in the anterior-posterior (AP) direction using traditional full volume registration. The improvement in standard deviation of the mean center of mass distance between the prostate volumes using a registration volume optimized to the prostate was 3.9 mm (p < 0.001) in the AP direction. The optimum registration volume size was 0 mm margin added to the prostate gland as outlined in the first image series.

Conclusions

Repeated MR imaging of the prostate for therapy set-up or therapy assessment will both require high precision tissue registration. With a subvolume based registration the prostate registration uncertainty can be reduced down to the order of 1 mm (1 SD) compared to several millimeters for registration based on the whole pelvis.

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Title: Registration accuracy for MR images of the prostate using a subvolume based registration protocol
Authors: Joakim H Jonsson
Patrik Brynolfsson
Anders Garpebring
Mikael Karlsson
Karin Söderström
Tufve Nyholm
Publication date: 01-12-2011
Publisher: BioMed Central
Published in: Radiation Oncology / Issue 1/2011
Electronic ISSN: 1748-717X
DOI: https://doi.org/10.1186/1748-717X-6-73

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Registration accuracy for MR images of the prostate using a subvolume based registration protocol

Abstract

Background

Methods

Results

Conclusions

Keynote webinar | Spotlight on medication adherence

Springer Medicine

Abstract

Background

Methods

Results

Conclusions

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