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01-10-2007 | Neuro

Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE)

Authors: Friedemann J. Gückel, Gunnar Brix, Michael Hennerici, Robert Lucht, Christine Ueltzhöffer, Wolfgang Neff

Published in: European Radiology | Issue 10/2007

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Abstract

The aim of the present study was a detailed analysis of the regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE) by means of functional magnetic resonance imaging (MRI). A group of 26 patients with SAE and a group of 16 age-matched healthy volunteers were examined. Using a well-established dynamic susceptibility contrast-enhanced MRI method, the regional cerebral blood flow (rCBF) and blood volume (rCBV) were quantified for each subject in 12 different regions in the brain parenchyma. As compared to healthy volunteers, patients with SAE showed significantly reduced rCBF and rCBV values in white matter regions and in the occipital cortex. Regions containing predominantly grey matter show almost normal rCBF and rCBV values. In conclusion, quantitative analysis of rCBF and rCBV values demonstrates clearly that SAE is a disease that is associated with a reduced microcirculation predominantly in white matter.

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Title: Regional cerebral blood flow and blood volume in patients with subcortical arteriosclerotic encephalopathy (SAE)
Authors: Friedemann J. Gückel
Gunnar Brix
Michael Hennerici
Robert Lucht
Christine Ueltzhöffer
Wolfgang Neff
Publication date: 01-10-2007
Publisher: Springer-Verlag
Published in: European Radiology / Issue 10/2007
Print ISSN: 0938-7994
Electronic ISSN: 1432-1084
DOI: https://doi.org/10.1007/s00330-007-0617-y

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