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Pediatric Nephrology
Published in: Pediatric Nephrology 10/2016

01-10-2016 | Review

Regenerating a kidney in a lymph node

Authors: Maria Giovanna Francipane, Eric Lagasse

Published in: Pediatric Nephrology | Issue 10/2016

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Abstract

The ultimate treatment for end-stage renal disease (ESRD) is orthotopic transplantation. However, the demand for kidney transplantation far exceeds the number of available donor organs. While more than 100,000 Americans need a kidney, only 17,000 people receive a kidney transplant each year (National Kidney Foundation’s estimations). In recent years, several regenerative medicine/tissue engineering approaches have been exploited to alleviate the kidney shortage crisis. Although these approaches have yielded promising results in experimental animal models, the kidney is a complex organ and translation into the clinical realm has been challenging to date. In this review, we will discuss cell therapy-based approaches for kidney regeneration and whole-kidney tissue engineering strategies, including our innovative approach to regenerate a functional kidney using the lymph node as an in vivo bioreactor.
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Metadata
Title
Regenerating a kidney in a lymph node
Authors
Maria Giovanna Francipane
Eric Lagasse
Publication date
01-10-2016
Publisher
Springer Berlin Heidelberg
Published in
Pediatric Nephrology / Issue 10/2016
Print ISSN: 0931-041X
Electronic ISSN: 1432-198X
DOI
https://doi.org/10.1007/s00467-015-3296-y

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